Gemcitabine-based Concurrent Chemoradiotherapy Versus Chemotherapy Alone in Patients with Locally Advanced Pancreatic Cancer

Wang, Buhai; Cao, Wei; Yu, Jinming; Wang, Xiaolei

doi:10.7314/apjcp.2012.13.5.2129

Cited by 6 publications

(7 citation statements)

References 12 publications

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“…We identified eight studies including 830 patients using the search strategy summarized in Figure S1, Supporting Information. There were five RCTs and three retrospective OBS …”

Section: Resultsmentioning

confidence: 99%

“…All the patients received gemcitabine‐based CT and had RT delivered via 3DCRT technique. Two studies used the dose fractionation of 50.4 Gy in 28 fractions and the remaining study used 45 Gy in 25 fractions followed by a 10 Gy in eight fractions. Evaluation using MERGE criteria revealed all three studies had moderate to high risk of bias (B2).…”

Section: Resultsmentioning

confidence: 99%

“…The studies defined OS differently. One used date of diagnosis, one used date of study entry and the last study used date of first treatment to date of death or last follow up. Addition of RT was associated with a statistically significant 52% reduction in the hazard for death (HR 0.48; 95% CI, 0.35–0.66, P < 0.001).…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Chemoradiotherapy versus chemotherapy for locally advanced unresectable pancreatic cancer: A systematic review and meta‐analysis

Soon

Chen

et al. 2018

Asia-Pac J Clncl Oncology

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“…We identified eight studies including 830 patients using the search strategy summarized in Figure S1, Supporting Information. There were five RCTs and three retrospective OBS …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Chemoradiotherapy versus chemotherapy for locally advanced unresectable pancreatic cancer: A systematic review and meta‐analysis

Soon

Chen

et al. 2018

Asia-Pac J Clncl Oncology

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“…21 A different approach that is currently being investigated is the concurrent application of full-cycle chemotherapy with radiotherapy. 22 Additionally, while the role of traditional chemoradiation in LAPC remains debatable, it will be intriguing to explore the role of more innovative forms of radiation such as stereotactic body radiation. 23,24 …”

Section: Discussionmentioning

confidence: 99%

Longer Course of Induction Chemotherapy Followed by Chemoradiation Favors Better Survival Outcomes for Patients With Locally Advanced Pancreatic Cancer

Faisal

Tsai

Blackford

et al. 2016

American Journal of Clinical Oncology

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Objectives At diagnosis, 30% of patients with pancreatic cancer are unresectable stage 3 locally advanced. The standard treatment for locally advanced pancreatic cancer (LAPC) is not defined. The current study was conducted to assess the roles of chemotherapy and chemoradiation for LAPC treatment. Methods Between June 2006-March 2011, 100 patients with LAPC were treated at Johns Hopkins Hospital. Retrospective analysis was performed to compare cumulative incidence of progression (CIP) and overall survival (OS) among different subgroups. Results For the 100 patients, median OS was 15.8 months and median CIP 8.4 months. The combination of chemotherapy and chemoradiation prior to disease progression was significantly associated with improved CIP (p=0.001) and improved OS when compared to chemoradiation alone (median OS 16.4 vs. 11.1 mo; p=0.03). Among patients receiving combination treatment, patients who received chemotherapy first followed by chemoradiation had a trend towards lower CIP (p=0.09) and improved OS (median OS: 18.1 vs. 11.0 mo, p=0.09). Patients who received >2 cycles of chemotherapy prior to chemoradiation had a significantly decreased CIP (p=0.008) and a trend toward better OS (median OS 19.4 vs. 15.7 mo, p=0.10). On multivariate analysis, receiving >2 cycles of chemotherapy prior to chemoradiation was associated with improved CIP. Conclusions While combination chemotherapy and chemoradiation is favored in the treatment of LAPC, longer induction chemotherapy may play a more important role in sensitization of tumors to subsequent chemoradiation. Our results support treating patients with induction chemotherapy for at least 3 cycles followed by consolidative chemoradiation. These results merit further validation by a prospective study.

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“…Its 5-year-survival rate is <5% due to its aggressive growth, metastasis and resistance to the majority of chemotherapies (1). Systemic chemotherapy remains reliant on a few drugs and has not significantly increased overall patient survival rates (2). Therefore, more effective therapeutic approaches are necessary for improving the outcome of pancreatic cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Cryptotanshinone suppresses the proliferation and induces the apoptosis of pancreatic cancer cells via the STAT3 signaling pathway

Yang

Chen

et al. 2015

Molecular Medicine Reports

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Abstract. Pancreatic cancer remains a challenging disease worldwide. Cryptotanshinone (CPT) is one of the active constituents of Salvia miltiorrhiza Bunge and exhibits significant antitumor activities in several human cancer cells. However, the efficacy and molecular mechanism of CPT in pancreatic cancer remains to be elucidated. In the present study, the effect of CPT on the proliferation, apoptosis and cell cycle of human pancreatic cancer cell BxPC-3 cells was evaluated. The results demonstrated that CPT inhibited proliferation of the BxPC-3 cells in a concentration-dependent manner, and significantly induced cell apoptosis and cell cycle arrest. The protein levels of cleaved caspase-3, caspase-9 and poly ADP ribose polymerase were upregulated, while the levels of c-myc, survivin and cyclin D1 were downregulated following treatment with CPT. In addition, CPT decreased the activities of signal transducer and activator of transcription 3 (STAT3) and several upstream regulatory signaling pathways after 24 h. However, CPT only inhibited the phosphorylation of STAT3 Tyr705 within 30 min, without marked effects on the phosphorylation of the other proteins. These results suggested that the inhibition of STAT3 activity by CPT was directly and independent of the upstream regulators in human pancreatic cancer. The present study demonstrated that CPT exerts anticancer effects by inducing apoptosis and cell cycle arrest via inhibition of the STAT3 signaling pathway in human BxPC-3 cells.

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Gemcitabine-based Concurrent Chemoradiotherapy Versus Chemotherapy Alone in Patients with Locally Advanced Pancreatic Cancer

Cited by 6 publications

References 12 publications

Chemoradiotherapy versus chemotherapy for locally advanced unresectable pancreatic cancer: A systematic review and meta‐analysis

Chemoradiotherapy versus chemotherapy for locally advanced unresectable pancreatic cancer: A systematic review and meta‐analysis

Longer Course of Induction Chemotherapy Followed by Chemoradiation Favors Better Survival Outcomes for Patients With Locally Advanced Pancreatic Cancer

Cryptotanshinone suppresses the proliferation and induces the apoptosis of pancreatic cancer cells via the STAT3 signaling pathway

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