Gemcitabine Is Ineffective in Recurrent, Preirradiated Cervical Cancer

Combination cisplatin-based chemotherapy could be a viable option for patients of good performance status with recurrent/metastatic cervical cancer, but further trials that report adequate survival and QoL data are sought. Response rates and improvements in survival are low. Cisplatin-based combinations have significant toxicity. Outcomes are poor and novel cytotoxic/biological agents and optimal scheduling need further investigation. Future trials need to stratify for and perform planned subgroup analysis with respect to previous treatment and site of recurrence.

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Chemotherapy for metastatic and recurrent cervical cancer

Scatchard

Forrest

Flubacher

et al. 2012

Cochrane Database of Systematic Reviews

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Evaluation of gemcitabine in previously treated patients with non-squamous cell carcinoma of the cervix: a phase II study of the Gynecologic Oncology Group

Schilder

Blessing

Cohn

2005

Gynecologic Oncology

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Concurrent cisplatin/gemcitabine chemotherapy along with radiotherapy in locally advanced cervical carcinoma: A phase II trial

Umanzor

Aguiluz

Pineda

et al. 2006

Gynecologic Oncology

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Gemcitabine Is Ineffective in Recurrent, Preirradiated Cervical Cancer

Cited by 7 publications

References 3 publications

Chemotherapy for metastatic and recurrent cervical cancer

Chemotherapy for metastatic and recurrent cervical cancer

Evaluation of gemcitabine in previously treated patients with non-squamous cell carcinoma of the cervix: a phase II study of the Gynecologic Oncology Group

Concurrent cisplatin/gemcitabine chemotherapy along with radiotherapy in locally advanced cervical carcinoma: A phase II trial

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