Gemcitabine-loaded gold nanospheres mediated by albumin for enhanced anti-tumor activity combining with CT imaging

Wang, Zhiming; Chen, Lina; Chu, Zhongyun; Huang, Chusen; Huang, Yuankui; Jia, Nengqin

doi:10.1016/j.msec.2018.03.025

Cited by 27 publications

(15 citation statements)

References 50 publications

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“…It can enhance the high permeability and retention effect of the drug in solid tumor and improve the circulation time in the blood. In addition, multi-functional nano-carriers can endow them with targeting function and improve the selective uptake efficiency of cells (Moros et al, 2013;Wang et al, 2016;Yin et al, 2017;Wang et al, 2018). Human serum albumin (HSA) is a kind of human-derived substance, which has the characteristics of non-toxicity, non-immunogenicity and good biocompatibility (Kratz, 2008).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol loaded glycyrrhizic acid-conjugated human serum albumin nanoparticles for tail vein injection II: pharmacokinetics, tissue distribution and bioavailability

Chen

Deng

et al. 2019

Drug Delivery

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There are many kinds of biological activities of resveratrol itself, but its clinical application is limited by its poor solubility in water and low bioavailability. Therefore, we have prepared glycyrrhizic acid-conjugated human serum albumin nanoparticles wrapping resveratrol nanoparticles (GL-HSA-RESNPs). The purpose of this study was to investigate the bioavailability, pharmacokinetics and tissue distribution of resveratrol in rats after single-dose tail vein injection administration of GL-HSA-RESNPs. A sensitive and reliable high performance liquid chromatography (HPLC) method was established to verify the content of resveratrol in rat plasma and organs. The C max value after GL-HSA-RESNPs administration was significantly higher than that of resveratrol suspension (933 ± 76.64 ng/mL vs. 618 ± 42.54 ng/mL, p < .01). The T max value obtained after GL-HSA-RESNPs administration was significantly shorter than that after resveratrol suspension administration (0.17 ± 0.01 h vs. 0.25 ± 0.01 h, p < .001). The bioavailability of GL-HSA-RESNPs was 4.25 times higher than that of the pure resveratrol. The concentration of resveratrol in the main organs of rats treated with the GL-HSA-RESNPs was higher than that in rats treated with the pure resveratrol. Rats treated with GL-HSA-RESNPs had the highest concentration of resveratrol in their liver. It is indicated that GL-HSA-RESNPs is a promising liver-targeted delivery system that improves the in vivo bioavailability of resveratrol.

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Section: Introductionmentioning

confidence: 99%

Resveratrol loaded glycyrrhizic acid-conjugated human serum albumin nanoparticles for tail vein injection II: pharmacokinetics, tissue distribution and bioavailability

Chen

Deng

et al. 2019

Drug Delivery

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“…We showed that 0.5 μM of RGDV-gemcitabine, but not 0.5 μM of gemcitabine, effectively inhibited the migration, invasion and adhesion of A549 cells in vitro 28 . We also showed that 0.5 μM of RGDV-gemcitabine, but not 0.5 μM of gemcitabine, effectively inhibited the wound healing of the monolayer of A549 cells in vitro.…”

Section: Discussionmentioning

confidence: 81%

Exploring the action of RGDV-gemcitabine on tumor metastasis, tumor growth and possible action pathway

Zhang

et al. 2020

Sci Rep

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The coupling of Arg-Gly-Asp-Val (RGDV) and gemcitabine led to a hypothesis that the conjugate (RGDV-gemcitabine) could inhibit tumor metastasis. To confirm this hypothesis the activities of RGDV-gemcitabine inhibiting tumor metastasis in vitro and in vivo were presented for the first time. AFM (atomic force microscopy) imaged that RGDV-gemcitabine was able to adhere onto the surface of serum-starved A549 cells, to block the extending of the pseudopodia. Thereby RGDV-gemcitabine was able to inhibit the invasion, migration and adhesion of serum-starved A549 cells in vitro. On C57BL/6 mouse model RGDV-gemcitabine dose dependently inhibited the metastasis of planted tumor towards the lung and the minimal dose was 0.084 µmol/kg/3 days. The decrease of serum TNF-α (tumor necrosis factor), IL-8 (interleukin-8), MMP-2 (matrix metalloprotein-2) and MMP-9 (matrix metalloprotein-9) of the treated C57BL/6 mice was correlated with the action pathway of RGDV-gemcitabine inhibiting the metastasis of the planted tumor towards lung.

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“…In another study, Wang et al128 developed a delivery system for gemcitabine (Gem) based on AuNP@BSA. The system was synthesized in a facile one-pot reaction via the reduction of HAuCl 4 with BSA as a stabilizer, which was subsequently conjugated to Gem through electrostatic interaction to give rise to the AuNP@BSA-Gem system.…”

Section: Biomedical Applications Of Albumin-aunpsmentioning

confidence: 99%

<p>Capping gold nanoparticles with albumin to improve their biomedical properties</p>

Bolaños

Kogan

Araya

2019

IJN

159

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Nanotechnology is an emerging field which has created great opportunities either through the creation of new materials or by improving the properties of existing ones. Nanoscale materials with a wide range of applications in areas ranging from engineering to biomedicine have been produced. Gold nanoparticles (AuNPs) have emerged as a therapeutic agent, and are useful for imaging, drug delivery, and photodynamic and photothermal therapy. AuNPs have the advantage of ease of functionalization with therapeutic agents through covalent and ionic binding. Combining AuNPs and other materials can result in nanoplatforms, which can be useful for biomedical applications. Biomaterials such as biomolecules, polymers and proteins can improve the therapeutic properties of nanoparticles, such as their biocompatibility, biodistribution, stability and half-life. Serum albumin is a versatile, non-toxic, stable, and biodegradable protein, in which structural domains and functional groups allow the binding and capping of inorganic nanoparticles. AuNPs coated with albumin have improved properties such as greater compatibility, bioavailability, longer circulation times, lower toxicity, and selective bioaccumulation. In the current article, we review the features of albumin, as well as its interaction with AuNPs, focusing on its biomedical applications.

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Gemcitabine-loaded gold nanospheres mediated by albumin for enhanced anti-tumor activity combining with CT imaging

Cited by 27 publications

References 50 publications

Resveratrol loaded glycyrrhizic acid-conjugated human serum albumin nanoparticles for tail vein injection II: pharmacokinetics, tissue distribution and bioavailability

Resveratrol loaded glycyrrhizic acid-conjugated human serum albumin nanoparticles for tail vein injection II: pharmacokinetics, tissue distribution and bioavailability

Exploring the action of RGDV-gemcitabine on tumor metastasis, tumor growth and possible action pathway

<p>Capping gold nanoparticles with albumin to improve their biomedical properties</p>

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