Gender and age in benign vocal fold lesions

Zhukhovitskaya, Alisa; Battaglia, Danielle; Khosla, Sid; Murry, Thomas; Sulica, Lucian

doi:10.1002/lary.24911

Cited by 103 publications

(90 citation statements)

References 31 publications

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“…As in previous publications [6,[8][9][10]31], the gender breakdown showed that vocal fold nodules were more frequent in women (N=142, 18.8% of the females) than in men (N=40, 12.3% of the males).…”

Section: Diagnosissupporting

confidence: 67%

“…This disparity between genders may be explained by differences in laryngeal structures, posterior glottis closure, molecular composition of the vocal folds tissues, hormonal factors and a higher fundamental frequency implying a greater load for vocal folds in females [29][30][31].…”

Section: Gender and Agementioning

confidence: 99%

“…It was hypothesized that mechanical stress experienced during high -pitched vibration is confined to the edge of the vocal fold, predisposing to the formation of nodules via activation of subepithelial fibroblasts and consequent excessive collagenous fiber deposition [31,32]. However, the difference in mean speaking frequency provides only a partial explanation [17].…”

Section: Diagnosismentioning

confidence: 99%

“…However, the difference in mean speaking frequency provides only a partial explanation [17]. Higher prevalence of nodules in females may also be explained by intrinsic differences in laryngeal anatomy and phonatory physiology, including differences in phonatory air pressure, in posterior glottis closure and in the ability of the membranous vocal fold to absorb phonotrauma [31]. According to Butler et al [29], the lower proportion of hyaluronic acid in females' superficial layer of the lamina propria and thus less shock-absorbing capacity as well as decreased capacity for tissue repair may amplify the potential for damage related to high frequency vibrations.…”

Section: Diagnosismentioning

confidence: 99%

“…In the female workers, nodules (N=87, 21%) and edema (N=49, 11.8%) were the most frequent diagnoses. These pathologies may be due to the posterior glottis insufficiency and higher fundamental frequency in young compared to older females [31,33]. Recent studies proposed that physiologic posterior glottis insufficiency functions as a sort of pseudo-paresis that predisposes females to phonotraumatic injury and development of pseudocysts [31,34].…”

Section: Diagnosismentioning

confidence: 99%

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Description of patients consulting the voice clinic regarding gender, age, occupational status, and diagnosis

Remacle

Petitfils

Finck

et al. 2016

Eur Arch Otorhinolaryngol

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Purpose. To describe the gender, age, occupational status and diagnosis of dysphonic patients.Method. We retrospectively analyzed the medical records of 1079 patients examined at the Voice clinic of the University hospital of Liège in French-speaking Belgium.Results. Overall, seven out of 10 patients who attended the voice clinic for dysphonia were females. The patients' ages ranged from 4 to 93 (mean=43.5). Females predominantly consulted at the age of 54 and males at the age of 9. Regarding the occupational status, workers represented more than half of our patients (53%), while 11.2% were unemployed, 15.4% were students, and 19.9% were retired. Regarding the diagnoses of the 1079 patients, nodules were the most common pathologies (n=182, 16.9% of the patients), prevailing in females (n=142, 18.8% of the females), encountered in 16.8% of the workers and 42.8% of the students consulting the voice clinic. Following nodules, laryngeal mobility disorders were diagnosed in 16.4% of the patients (n=177), mainly females (n=115), and was the most frequent diagnosis in retirees (n=75, 34.9%). Conclusions. The majority of the patients consulting the voice clinic for dysphonia were adult females, in their workforce, diagnosed with vocal nodules. The identification of the patients' characteristics and diagnoses is important to develop treatments and prevention of dysphonia, estimate their costs, and allow comparisons across referral centers.

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Section: Diagnosissupporting

confidence: 67%

Section: Gender and Agementioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

Section: Diagnosismentioning

confidence: 99%

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Description of patients consulting the voice clinic regarding gender, age, occupational status, and diagnosis

Remacle

Petitfils

Finck

et al. 2016

Eur Arch Otorhinolaryngol

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Possible association between Helicobacter pylori infection and vocal fold leukoplakia

Chen

Yang

et al. 2018

Head & Neck

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Background Several studies have indicated the larynx as possible Helicobacter pylori (H. pylori) reservoirs. This study explored the association between H. pylori and vocal fold leukoplakia. Methods The case‐control study involved 51 patients with vocal fold leukoplakia and 35 control patients with vocal polyps. Helicobacter pylori was detected in tissues by the rapid urease test, nested polymerase chain reaction (PCR), and single‐step PCR. The H. pylori‐specific immunoglobulin antibodies were detected in plasma by enzyme‐linked immunosorbent assay (ELISA). Results Helicobacter pylori‐positive rate of vocal fold leukoplakia and vocal polyps was 23.5% versus 11.4% (P = .157), 37.2% versus 14.3% (P = .020), 27.5% versus 8.6% (P = .031), and 70.6% versus 68.6% (P = .841) detected by rapid urease test, nested PCR, single‐step PCR, and ELISA, respectively. Regression analysis indicated that H. pylori infection (P = .044) was the independent risk factor for vocal fold leukoplakia. Conclusion Helicobacter pylori infection exists in the larynx and may be associated with vocal fold leukoplakia.

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