2013
DOI: 10.1371/journal.pone.0081664
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Gender and Age Interact to Affect Early Outcome after Intracerebral Hemorrhage

Abstract: BackgroundIntracerebral hemorrhage (ICH) is a common and devastating form of cerebrovascular disease. In ICH, gender differences in outcomes remain relatively understudied but have been examined in other neurological emergencies. Further, a potential effect of age and gender on outcomes after ICH has not been explored. This study was designed to test the hypothesis that age and gender interact to modify neurological outcomes after ICH.MethodsAdult patients admitted with spontaneous primary supratentorial ICH f… Show more

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Cited by 55 publications
(49 citation statements)
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“…33 In another study of ICH outcomes by sex, a significant interaction between sex and age was found, with female sex being associated with a higher risk of poor outcomes in those over 70 years of age. 34 Finally, there may be sex-specific effects of genetic polymorphisms, including apolipoprotein E, associated with poor outcomes in ICH. 35 There are many unanswered questions regarding sex and gender differences in spontaneous ICH, and future emergency care research should focus on potential sex differences in risk factors, presentation, management, and prognosis.…”
Section: Hemorrhagic Strokementioning
confidence: 99%
“…33 In another study of ICH outcomes by sex, a significant interaction between sex and age was found, with female sex being associated with a higher risk of poor outcomes in those over 70 years of age. 34 Finally, there may be sex-specific effects of genetic polymorphisms, including apolipoprotein E, associated with poor outcomes in ICH. 35 There are many unanswered questions regarding sex and gender differences in spontaneous ICH, and future emergency care research should focus on potential sex differences in risk factors, presentation, management, and prognosis.…”
Section: Hemorrhagic Strokementioning
confidence: 99%
“…Emerging clinical data indicate that sex is a factor in ICH outcome, possibly due to the presence or absence of female gonadal hormones [4,5,6]. Preclinical studies have also raised the possibility of a sex effect on ICH outcome.…”
Section: Introductionmentioning
confidence: 99%
“…Some methodologic problems that would account for the inconsistencies and heterogeneity of the available data have been noted, such as differences in metrics used, length of study period, race/ethnicity of participants, etiology, or the adjustments made in the statistical analysis. [4][5][6] Moreover, most of the available data are from retrospective stroke registries [6][7][8][9][10][11][12] or from studies published more than a decade ago. 13,14 The most recent published series comes from Asian countries, 15,16 and probably have some bias and racial/ethnic specificity.…”
mentioning
confidence: 99%