Gender and age related differences in left ventricular function and geometry with focus on the long axis

Sveälv, Bente Grüner; Fritzon, Gunilla; Andersson, Bert

doi:10.1016/j.euje.2005.06.008

Cited by 33 publications

(28 citation statements)

References 28 publications

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“…The two-way ANOVA tests among 21 groups of coefficients corresponding to the 39 studied subjects show that only 6 of the coefficients were statistically different (p < 0.05; table 2). This is also consistent with the data presented by Grüner Sveälv et al [3] who found that both systolic and diastolic short-axis indices related to cardiac function are unaffected by aging. They investigated these indices in 82 healthy individuals from the general population within the age range of 20-70 years [3].…”

Section: Discussionsupporting

confidence: 82%

“…Although no study - to the best of our knowledge - has compared the longitudinal viscoelasticity between different age groups, some studies have shown that several longitudinal indices related to cardiac function are affected due to aging [3,60]. The age-related changes in longitudinal viscoelastic parameters should be tested to find out whether these structural parameters are also correlated with functional indices.…”

Section: Study Limitationsmentioning

confidence: 99%

“…Aging-associated phenomena have been extensively described regarding the signaling pathways, structure and function [1,2,3,4,5]. The total number of cardiomyocytes decreases with age, and this collective loss impairs contractile performance of the heart.…”

Section: Introductionmentioning

confidence: 99%

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Aging Does Not Affect Radial Viscoelastic Behavior of the Left Ventricle

et al. 2013

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Objectives: This study investigates the effect of aging on the radial viscoelastic behavior of the left ventricle (LV) based on a previously validated model that uses myocardial tissue phase mapping (TPM) of cine phase-contrast MRI. Methods: Previous studies suggest that aging remarkably influences regional myocardial motion, mostly myocardial velocities in both radial and long-axis directions. However, the effect of aging on cardiac viscoelasticity, which exhibits time-dependent strain, has not been elucidated yet. In this study, myocardial velocity and displacement mapping of the LV was performed using TPM in 39 healthy subjects divided into three age groups. The viscoelasticity parameters were obtained for each segment of the LV and compared among the studied groups. Results: The analyses showed that myocardial elasticity ranged from approximately 20 to -20 dyne/cm² during a cardiac cycle, and the myocardial viscous-damping component ranged from -1 to 1 dyne × s/cm². Overall, no statistically significant difference was observed in the viscoelasticity components among the subjects in the different age groups (p > 0.05). Conclusion: Myocardial viscoelastic behavior of the LV in radial direction was found to be considerably similar in pattern and magnitude among the studied subjects of different age groups with no statistically significant difference, despite the fact that the regional myocardial velocities change due to aging.

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Section: Discussionsupporting

confidence: 82%

Section: Study Limitationsmentioning

confidence: 99%

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Aging Does Not Affect Radial Viscoelastic Behavior of the Left Ventricle

et al. 2013

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“…Maximal velocities were calculated by the program from the steepest parts of systolic and diastolic movements. Amplitudes, time intervals and velocities were analysed as described earlier 12. Calculation of LVEF was performed according to the Teichholz formula 18.…”

Section: Methodsmentioning

confidence: 99%

“…There is increasing evidence that the basal parts of the ventricles are sensitive to changing conditions, including pathological states, response to pharmacological treatment, regional dysfunction and normal ageing 9 – 12. When this study was initiated, there was sparse information available about the possible importance of LAX motion of the ventricles and no data on associations with survival.…”

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confidence: 99%

Ventricular long-axis function is of major importance for long-term survival in patients with heart failure

Sveälv

Olofsson

Andersson

2008

Heart

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Simultaneous multislice steady‐state free precession myocardial perfusion with full left ventricular coverage and high resolution at 1.5 T

McElroy

Ferrazzi

Nazir

et al. 2022

Magnetic Resonance in Med

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To implement and evaluate a simultaneous multi-slice balanced SSFP (SMS-bSSFP) perfusion sequence and compressed sensing reconstruction for cardiac MR perfusion imaging with full left ventricular (LV) coverage (nine slices/heartbeat) and high spatial resolution (1.4 × 1.4 mm 2 ) at 1.5T. Methods:A preliminary study was performed to evaluate the performance of blipped controlled aliasing in parallel imaging (CAIPI) and RF-CAIPI with gradient-controlled local Larmor adjustment (GC-LOLA) in the presence of fat. A nine-slice SMS-bSSFP sequence using RF-CAIPI with GC-LOLA with high spatial resolution (1.4 × 1.4 mm 2 ) and a conventional three-slice sequence with conventional spatial resolution (1.9 × 1.9 mm 2 ) were then acquired in 10 patients under rest conditions. Qualitative assessment was performed to assess image quality and perceived signal-to-noise ratio (SNR) on a 4-point scale (0: poor image quality/low SNR; 3: excellent image quality/high SNR), and the number of myocardial segments with diagnostic image quality was recorded. Quantitative measurements of myocardial sharpness and upslope index were performed.Results: Fat signal leakage was significantly higher for blipped CAIPI than for RF-CAIPI with GC-LOLA (7.9% vs. 1.2%, p = 0.010). All 10 SMS-bSSFP perfusion datasets resulted in 16/16 diagnostic myocardial segments. There were no significant differences between the SMS and conventional acquisitions in terms of image quality (2.6 ± 0.6 vs. 2.7 ± 0.2, p = 0.8) or perceived SNR (2.8 ± 0.3 vs. 2.7 ± 0.3, p = 0.3). Inter-reader variability was good for both image quality (ICC = 0.84) and perceived SNR (ICC = 0.70). Myocardial sharpness was improved using the SMS sequence compared to the conventional Sarah McElroy and Giulio Ferrazzi contributed equally to this work.

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Gender and age related differences in left ventricular function and geometry with focus on the long axis

Cited by 33 publications

References 28 publications

Aging Does Not Affect Radial Viscoelastic Behavior of the Left Ventricle

Aging Does Not Affect Radial Viscoelastic Behavior of the Left Ventricle

Ventricular long-axis function is of major importance for long-term survival in patients with heart failure

Simultaneous multislice steady‐state free precession myocardial perfusion with full left ventricular coverage and high resolution at 1.5 T

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