Gender- and age-specific impairment of rat performance in the Morris water maze following prenatal exposure to an MRI magnetic field

Jiang, Ma Li; Han, Tai Zhen; Pang, Wei; Liang, Li

doi:10.1016/j.brainres.2003.09.060

Cited by 15 publications

(13 citation statements)

References 21 publications

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“…Previous reports have not found gender differences [7,9], but there is some evidence for such differences in the effects of various types of magnetic field [26][27][28][29][30][31]. Our results do not agree with some studies in which suicide numbers were found to be inversely related to geomagnetic activity [12,13].…”

Section: Discussioncontrasting

confidence: 99%

Association of geomagnetic disturbances and suicides in Japan, 1999–2010

Tada

Nishimura

Nakatani

et al. 2013

Environ Health Prev Med

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Objectives Previous studies have shown a positive relationship between geomagnetic disturbances and an increased incidence of suicide. The Japanese suicide rate is the ninth highest in the world, but there have been no reports examining the relationship between geomagnetic disturbance and the number of suicides, and, therefore, this paper examines this relationship. Methods The number of Japanese suicides per month from January 1999 to December 2010 was obtained, and it was found that a total of 262,596 males and 102,539 females committed suicide during this period. To adjust the other factors which affect the number of suicides, a multiple linear regression analysis with backward elimination was carried out, with the monthly number of suicides as the response variable and the monthly mean K index value, monthly mean number of sunspots, monthly mean unemployment rate, proportion of elderly people (%), monthly mean air pressure (hPa), monthly mean air temperature (°C), monthly mean humidity (%), and monthly mean day length (h) as the explanatory variables. ResultsIn the multiple linear regression analysis for males, the monthly mean K index value was associated with the monthly number of suicides, but in females, the monthly mean K index value was not associated with the monthly number of suicides. Conclusion In this study, we generated a hypothesis that geomagnetic disturbances may trigger male suicides.

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Section: Discussioncontrasting

confidence: 99%

Association of geomagnetic disturbances and suicides in Japan, 1999–2010

Tada

Nishimura

Nakatani

et al. 2013

Environ Health Prev Med

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“…In male rats, the relationship was a positive correlation, but in female rats the relationship was a negative correlation. This finding corresponds with evidence for sex differences in the effects of various types of magnetic field [12][13][14][15][16][17].…”

Section: Discussionmentioning

confidence: 57%

Effects of Power-Frequency Magnetic Fields on Body Mass in Rats: A Pooled Analysis

Nishimura

Tada²,

Teramukai³

et al. 2012

PIER Letters

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Abstract-There is some evidence that exposure of various animals to a power-frequency magnetic field can cause increases in body mass. However, the precise nature of the relationship is not clear, particularly for long-term exposure. To clarify the relationship between long-term power-frequency magnetic field exposure (2 years) and animal body mass, we conducted a pooled analysis of data in two studies to examine the impact of power-frequency magnetic field exposure on body mass as compared with sham-exposed rats of both sexes. Relative body mass was the response variable, and the study duration (in weeks), magnetic flux density (µT), and daily exposure time (hours/day) were the explanatory variables with adjustment for the study. We analyzed by sex. The P -value (P ) was defined as the probability of having observed our data (or more extreme data) when the null hypothesis was true. In multiple linear regression analyses of male and female rats, performed separately, we obtained estimates of the effect on relative body mass of study duration (coefficients 0.0225 and 0.0201, respectively; both P < 0.0001), magnetic flux density (coefficient 0.0002 for males, P < 0.0001; coefficient −0.0002 for females, P = 0.0015), and daily exposure time (coefficient 0.046 for

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“…With using the tendency strategy, a rat will not be able to accurately determine the location of the target, but it knows the direction of it. The marginal strategy reflects instinctive behaviour and the tracks of rats usually appear in the edge of the pool; and the random strategy, which is thought to be a blind movement, is used by rats that presented themselves in the most areas of the maze (Jiang et al, 2004).…”

Section: Methodsmentioning

confidence: 99%

“…Based on rats' trace images, strategies are often grouped into categories including spatial strategies, repetitive looping strategies and nonspatial strategies, and spatial strategies are considered to be the most efficient method of finding the hidden platform in the MWM (Brody and Holtzman, 2006;Janus, 2004). Additionally, another search strategy classification includes straight, tendency, marginal and random strategies (Jiang et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Methylphenidate effects on search strategy of an animal model of attention-deficit/ hyperactivity disorder

Tian¹

2013

Afr. J. Pharm. Pharmacol.

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This study is aimed at investigating the effects of methylphenidate about search strategy use on the spontaneously hypertensive rat, an animal model of attention-deficit/hyperactivity disorder in the Morris water maze. The methylphenidate group rats were given intraperitoneal injection of methylphenidate (10 mg/kg) dissolved in saline 30 min before daily training for 6 consecutive days. In the same way, the model group and the control group rats were only administered equalized volume of saline, respectively. From the second day of trials, the frequency of using tendency-straight strategy to search the hidden platform was significantly increased in all of the training rats. Additionally, the methylphenidate group rats used straight strategy more frequently than the model group rats did on days 1, 3 and 6, respectively. The data indicated that methylphenidate might play a positive role in improving spatial learning ability of the spontaneously hypertensive rat by adding its straight search strategy use in the Morris water maze.

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Gender- and age-specific impairment of rat performance in the Morris water maze following prenatal exposure to an MRI magnetic field

Cited by 15 publications

References 21 publications

Association of geomagnetic disturbances and suicides in Japan, 1999–2010

Association of geomagnetic disturbances and suicides in Japan, 1999–2010

Effects of Power-Frequency Magnetic Fields on Body Mass in Rats: A Pooled Analysis

Methylphenidate effects on search strategy of an animal model of attention-deficit/ hyperactivity disorder

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