Gender and comorbidity among individuals with opioid use disorders in the NESARC study

Abstract

This study examines gender differences in the association of lifetime mental and substance use disorders among individuals with opioid use disorders in the United States. The sample (N=578) is from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), which is a representative household survey. Bivariate analyses and logistic regression modeling were conducted. About 70% of the sample had a lifetime non-substance use Axis I disorder; women were about twice as likely as men to have either a mood or anxiety disorder. About half of the sample had a personality disorder, with women more likely to have paranoid disorder and men more likely to have antisocial personality disorder. Individuals with a lifetime mental disorder were about three times more likely than others to be dependent on other substances, independent of gender. The study demonstrated an inverse relationship between lifetime mental and other substance use disorders, with women having significantly higher odds for several of the mental disorders and men having greater odds of other substance use disorders.

Suicidal Ideation and Suicide Attempt Across Stages of Nonmedical Prescription Opioid Use and Presence of Prescription Opioid Disorders Among U.S. Adults

“…Given the extent of the problem, many studies have characterized individuals who use nonmedical prescription opioids to better understand the population of nonmedical prescription opioid users (Becker et al, 2008;Brands et al, 2004;Huang et al, 2006;Martins et al, 2009b;Sigmon, 2006). A strong association between psychiatric disorders and nonmedical prescription opioid use (Becker et al, 2008;Cicero et al, 2008) and disorders (Grella et al, 2009;Huang et al, 2006;Martins et al, 2009a) suggests the importance of addressing mental health problems among this population. A high risk for mental disorders motivates examination of risk for suicidal behavior (ideation and/or attempt), as mental disorders are among the strongest risk factors for suicidal ideation (Goldney et al, 2000).…”

Effect of Psychiatric Severity on the Outcome of Methadone Maintenance Treatment

“…Studies carried out in the general population have revealed percentages of lifetime psychiatric comorbidity with SUD ranging from 30 to 60%, and odds ratios (OR) from 2.5 to 5 [1][2][3] . An apparently stronger association has been detected between SUD and other psychiatric disorders in opioid-dependent populations, in which approximately 70% of subjects meet the criteria for at least one lifetime DSM Axis I (nonsubstance use) disorder and 50% for Axis II personality disorders [4] . Moreover, with regard to the clinical population, the figures obtained are even higher, with rates of psychiatric comorbidity reaching 80-90% for Axis I dis-orders [5][6][7] .…”

Dependencia de Opiáceos tipo II o antisocial: utilidad del Modelo Psicobiológico de Cloninger en adicciones

“…En consumidores de opiáceos, Frei y Rehm (2002) encontraron que el 42% presentaban TP, mientras que Grella et al (2009) obtuvieron una prevalencia del 50%. En España, Haro et al (2004) observaron que el 58% de los dependientes de opiáceos presentaban al menos un TP, siendo el trastorno límite de la personalidad (TLP) el más prevalente.…”