Gender- and Ethnicity-Related Differences in Optic Nerve Head Topography in Healthy Indian and Caucasian Participants

Pilat, Anastasia; Gottlob, Irène; Sheth, Viral; Thomas, Mervyn G; Proudlock, Frank A

doi:10.3109/01658107.2014.894535

Cited by 4 publications

(4 citation statements)

References 16 publications

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“…Moreover, glaucoma cupping might be an indicative of early-stage disease or high risk of disease development that could indeed cause vision impairment in later life in a person who will need ongoing care to prevent the disease development or progression. While our data showed association of glaucoma cupping with male gender and older age, there is no consensus in the literature with studies indicating significant effects only of aging 27 , only of male gender 28 , both 29 or neither 30 . A detailed analysis of the optic nerve head topography would be indicated to a better understand of those variables’ effects.…”

Section: Discussioncontrasting

confidence: 96%

Prevalence of ocular findings regardless of visual acuity status in older adults from the Brazilian Amazon Region

Berezovsky

Watanabe

Mitsuhiro

et al. 2021

Sci Rep

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Recently, it has been recommended that population-based studies report not only frequencies of vision impairment and blindness but also any ocular abnormalities that might lead an individual to seek for eyecare services. The current study aimed to determine prevalence of ocular findings regardless of visual acuity (VA) status in older adults from the Brazilian Amazon Region. Disturbances were grouped into: Eyelids; Anterior Segment; Posterior Segment; Increased intraocular pressure; and Overall Globe. The presence of an ocular finding was considered positive when any abnormality was noted, regardless of VA. Refractive errors were not considered. A total 2384 eligible persons were enumerated and 2041 (85.6%) examined. The prevalence of ocular disturbances in either eye was 87.0% and was associated with male gender, older age, lower education, and rural residence. Overall, main findings were pterygium, cataract, and pinguecula, occurring in 58.8%, 45.4% and 17.4%, respectively. Among individuals with 20/20 VA in both eyes, the most frequent findings were pterygium, pinguecula, and glaucoma cupping, occurring in 47.4%, 31.2% and 6.5%, respectively. The high prevalence of ocular findings observed in this population reinforces that different conditions might not immediately decrease VA but can indicate risk and/or discomfort symptoms and should be considered when planning public health ophthalmic services.

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Section: Discussioncontrasting

confidence: 96%

Prevalence of ocular findings regardless of visual acuity status in older adults from the Brazilian Amazon Region

Berezovsky

Watanabe

Mitsuhiro

et al. 2021

Sci Rep

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“…We speculate that sex may have an influence on the detected difference in the ONH parameters between PACG and POAG, as the ratio of women has been consistently higher in patients with PACG in epidemiologic studies,34–37 and there is evidence indicating that ONH morphology may be different between men and women 38. The other possibility for explaining the difference between our findings and Nouri-Mahdavi et al’s results28 is that the difference in ONH parameters between POAG and PACG might be more appreciable in the early stages of glaucoma, and in more advanced cases as in our study and that of Boland et al’s,26 the pattern of structural damage may become similar.…”

Section: Discussionmentioning

confidence: 91%

Comparison of Vascular Density and Structural Patterns Between Primary Open Angle Glaucoma and Primary Angle Closure Glaucoma

Mohammadi

Tabatabaei

et al. 2022

Journal of Glaucoma

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Purpose: To compare the pattern of vascular density and structural damage in primary open angle glaucoma (POAG) with primary angle closure glaucoma (PACG) using optical coherence tomography (OCT) and OCT angiography (OCTA) in the optic nerve head, circumpapillary, and macular regions, respectively. Materials and Methods:One hundred thirty-one eyes of 82 patients (53 eyes with PACG and 78 eyes with POAG) were enrolled in this study. The patients underwent complete ophthalmic examination, Bruch membrane opening minimum rim width, circumpapillay retinal nerve fiber layer (cpRNFL), and macular ganglion cell complex (GCC) measurements and vascular density determination of the peripapillary and macular area with OCT and OCTA. A linear mixed model was used for the statistical analysis.Results: There was no significant difference between the 2 groups in terms of age (P = 0.94) and visual field mean deviation (P = 0.78). Female-to-male ratio was higher in PACG patients than the POAG group (P = 0.02), and AL was shorter in PACG eyes (P < 0.001). cpRNFL and GCC were not different between the 2 groups (all P values > 0.05, except for nasal segment cpRNFL). Vessel densities in the peripapillary and macular areas were comparable between the 2 groups (all P values > 0.05). Although Bruch membrane opening minimum rim width was thicker in PACG eyes on univariate analysis, the multivariable analysis showed no significant difference between the 2 groups (P > 0.05).Conclusions: PACG and POAG eyes with similar visual field damages have comparable structural damage patterns in the peripapillary and inner macular thickness and vessel density measurements.

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“…3) Furthermore, PPV values can be influenced by the prevalence of the disease (ODE in this case). It will be valuable to validate the performance of these chosen cutoffs of RNFL measurements in different clinical settings and in participants of different ethnicity, as all patients in our study were Caucasians and it is well known that RNFL thickness varies by race/ethnicity [25,26]. In conclusion, although the correct differential diagnosis between ODE and PODE still relies on a careful medical history taking and other ancillary testing, the OCT RNFL analysis may help the initial selection of patients presenting with elevated optic disc to direct towards a prompt and extensive management.…”

Section: Discussionmentioning

confidence: 99%

Optical coherence tomography is a useful tool in the differentiation between true edema and pseudoedema of the optic disc

et al. 2018

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PurposeTo assess the usefulness of spectral-domain optical coherence tomography (SD-OCT) peripapillary retinal nerve fiber layer (RNFL) thickness measurement in discriminating early phase optic disc edema (ODE) from pseudoedema (PODE).MethodsHospital-based, multicenter, cross-sectional study involving external patients referred for recent identification of “presumed ODE”. Patients underwent SD-OCT optic nerve head (ONH) RNFL thickness measurement at their first evaluation. In 155 of these, the causative etiology was subsequently ascertained and the respective eyes (one per patient) were assigned to the ODE (95 eyes) or PODE (60 eyes) group. Admission SD-OCT data were retrieved and used for the analysis. ROC curve analysis was used to calculate specificity, sensitivity and predictive value (PV) of the RNFL values.ResultsThe PODE group was significantly younger than the ODE group (p = 0.007). The average and any single-quadrant RNFL thickness was significantly higher in the ODE group compared with the PODE and control groups. The average and the inferior quadrant thicknesses tested the most powerful parameters to differentiate ODE from PODE. A cutoff value of ≥ 110 μm for the average area, or of ≥ 150 μm for the inferior quadrant was associated with maximal sensitivity and specificity with positive PV greater than 80%.ConclusionsThe SD-OCT evaluation of the peripapillary RNFL achieved good specificity, sensitivity and positive PV in discriminating between ODE and PODE. Despite the correct differential diagnosis between these categories still relies on a careful medical history taking and other ancillary testing, we proved the usefulness of SD-OCT RNFL measurement in supporting the diagnostic process.

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Gender- and Ethnicity-Related Differences in Optic Nerve Head Topography in Healthy Indian and Caucasian Participants

Cited by 4 publications

References 16 publications

Prevalence of ocular findings regardless of visual acuity status in older adults from the Brazilian Amazon Region

Prevalence of ocular findings regardless of visual acuity status in older adults from the Brazilian Amazon Region

Comparison of Vascular Density and Structural Patterns Between Primary Open Angle Glaucoma and Primary Angle Closure Glaucoma

Optical coherence tomography is a useful tool in the differentiation between true edema and pseudoedema of the optic disc

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