2011
DOI: 10.1038/npp.2011.22
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Gender and Iron Genes May Modify Associations Between Brain Iron and Memory in Healthy Aging

Abstract: Brain iron increases with age and is abnormally elevated early in the disease process in several neurodegenerative disorders that impact memory including Alzheimer's disease (AD). Higher brain iron levels are associated with male gender and presence of highly prevalent allelic variants in genes encoding for iron metabolism proteins (hemochromatosis H63D (HFE H63D) and transferrin C2 (TfC2)). In this study, we examined whether in healthy older individuals memory performance is associated with increased brain ir… Show more

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Cited by 95 publications
(84 citation statements)
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References 97 publications
(173 reference statements)
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“…Given the role of excessive unbound iron in induction of mitochondrial dysfunction, energetic decline and oxidative stress, its accumulation is likely to have detrimental cognitive consequences. In extant cross-sectional studies in healthy adults, greater iron content in subcortical structures was associated with poorer memory performance (Bartzokis et al, 2011; Rodrigue et al, 2013; Ghadery et al, 2015), lower general cognitive aptitude (Penke et al, 2012), mental slowing (Pujol et al, 1992; Sullivan et al, 2009), and poorer cognitive and motor control (Adamo, Daugherty, Raz, 2014). Greater iron content and small hippocampal volume conjointly contributed to cross-sectional age differences in memory (Rodrigue et al, 2013).…”
Section: Brain Iron and Cognitive Performancementioning
confidence: 99%
“…Given the role of excessive unbound iron in induction of mitochondrial dysfunction, energetic decline and oxidative stress, its accumulation is likely to have detrimental cognitive consequences. In extant cross-sectional studies in healthy adults, greater iron content in subcortical structures was associated with poorer memory performance (Bartzokis et al, 2011; Rodrigue et al, 2013; Ghadery et al, 2015), lower general cognitive aptitude (Penke et al, 2012), mental slowing (Pujol et al, 1992; Sullivan et al, 2009), and poorer cognitive and motor control (Adamo, Daugherty, Raz, 2014). Greater iron content and small hippocampal volume conjointly contributed to cross-sectional age differences in memory (Rodrigue et al, 2013).…”
Section: Brain Iron and Cognitive Performancementioning
confidence: 99%
“…In addition, it would be valuable to thoroughly assess learning and memory in large cohorts of patients with clinical hemochromatosis (i.e. not just individuals with predisposing mutations) and to further investigate suggestions of detrimental effects of high hippocampal iron on verbal memory and high basal ganglia iron on working memory (Bartzokis et al, 2011).…”
Section: Discussionmentioning
confidence: 99%
“…Li et al, 2014). The nuclei studied the most by far with in-vivo MRI are the striatum and the globus pallidus (Bartzokis et al, 1997; Bartzokis et al, 2011; Bilgic et al, 2012; Cherubini, Peran, Caltagirone, Sabatini, & Spalletta, 2009; Haacke et al, 2005; Haacke et al, 2010; Hagemeier et al, 2013; Pfefferbaum, Adalsteinsson, Rohlfing, & Sullivan, 2009; Xu et al, 2008). The age dependency in MR based iron estimates of the substantia nigra, red nucleus, thalamus, the pulvinar complex and the cerebellar dentate nucleus is studied to a lesser extent, and with greater variability of results (Bilgic et al, 2012; Haacke et al, 2010; W.…”
Section: Introductionmentioning
confidence: 99%