Gender and preterm birth: Is male fetal gender a clinically important risk factor for preterm birth in high-risk women?

Teoh, Penelope J.; Ridout, Alex; Seed, Paul; Tribe, Rachel M.; Shennan, Andrew

doi:10.1016/j.ejogrb.2018.04.025

Cited by 28 publications

(17 citation statements)

References 13 publications

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“…We found no statistically significant association between the gender of neonates and LPT delivery. This was in agreement with Teoh et al [18] However, several earlier studies [19][20][21][22] reported an increased risk of preterm delivery associated with male fetus. Wilms et al [21] suggested an effect of maternal race on the association between gender and preterm delivery.…”

Section: Discussionsupporting

confidence: 92%

Outcome of late preterm newborns in Upper Egypt

El-Hawary

Amin

Elmenem

2020

Egypt Pediatric Association Gaz

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Background: The incidence of preterm births is increasing and has become a global health concern. This study aimed to compare the outcome of late preterm (LPT) to full term (FT) neonates at two large hospitals in Upper Egypt. Results: Out of 250 newborns included in the study, 180 (72%) were FT and 70 (28%) were LPT. More than half of the LPT newborns (52.9%) were admitted to the neonatal intensive care unit (NICU), compared with 26.7% of FT newborns. Delivery of LPT was associated with an increased risk of neonatal morbidity, including jaundice requiring phototherapy (34.3% vs. 7.8%), respiratory morbidities (32.9% vs. 13.9%), hypoglycemia (8.6% vs. 1.7 %), and convulsions (4.3% vs. 0.6%). Conclusions: LPT neonates were more susceptible to suffer from jaundice and respiratory distress among other morbidities. They also had a higher rate of NICU admission, longer duration of NICU stay, as well as a higher mortality rate. The best treatment of late prematurity is to prevent it. Public and professional awareness of the problems associated with late prematurity should be highlighted. Follow-up programs for early detection and intervention for long term complications are recommended.

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Section: Discussionsupporting

confidence: 92%

Outcome of late preterm newborns in Upper Egypt

El-Hawary

Amin

Elmenem

2020

Egypt Pediatric Association Gaz

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“…Sex of the child had no any risks for preterm births. This was in line with another study who also showed no signi cant association between sex of the child and preterm births [50]. However, several studies have linked male babies with preterm births [51][52][53].…”

Section: Discussionsupporting

confidence: 90%

Incidence, risk factors and consequences of preterm birth – findings from a multicentric observational study in Nepal

Gurung¹,

Wrammert

Sunny³

et al. 2020

Preprint

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Background: Preterm birth is a worldwide epidemic and a leading cause of neonatal mortality. In this study, we aimed to evaluate the incidence, risk factors and consequences of preterm birth in Nepal.Methods: This was an observational study conducted in 12 public hospitals of Nepal. All the babies born during the study period were included in the study. Babies born <37 weeks of gestation were classified as preterm births. For the association and outcomes for preterm birth, univariate followed by multiple regression analysis was conducted. Results: The incidence of preterm was found to be 93 per 1000 live births. Mothers aged less than 20 years (aOR 1.26 ;1.15-1.39) had a high risk for preterm birth. Similarly, education of the mother was a significant predictor for preterm birth: illiterate mothers (aOR 1.41; 1.22-1.64), literate mothers (aOR 1.21; 1.08-1.35) and mothers having basic level of education (aOR 1.17; 1.07-1.27). Socio-demographic factors such as smoking (aOR 1.13; 1.01-1.26), use of polluted fuel (aOR 1.26; 1.17-1.35) and sex of baby (aOR 1.18; 1.11-1.26); obstetric factors such as nulliparity (aOR 1.33; 1.20-1.48), multiple delivery (aOR 6.63; 5.16-8.52), severe anemia during pregnancy (aOR 3.27; 2.21-4.84), antenatal visit during second trimester (aOR 1.13; 1.05-1.22) and third trimester (aOR 1.24; 1.12-1.38), <4 antenatal visits during pregnancy (aOR 1.49; 1.38-1.61) were found to be significant risk factors of preterm birth. Preterm has a risk for pre-discharge mortality (10.60; 9.28-12.10). Conclusion: In this study, we found high incidence of preterm birth. Various socio-demographic, obstetric and neonatal risk factors were associated with preterm birth. Risk factor modifications and timely interventions will help in the reduction of preterm births and associated mortalities. Trial registration: ISRCTN30829654

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“…Sex of the child had no any risks for preterm births. This was in line with another study who also showed no significant association between sex of the child and preterm births [43]. However, several studies have linked male babies with preterm births [44][45][46].…”

Section: Discussionsupporting

confidence: 90%

Incidence, risk factors and consequences of preterm birth – findings from a multicentric observational study in Nepal

Gurung¹,

Wrammert

Sunny³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Preterm birth is a worldwide epidemic and a leading cause of neonatal mortality. In this study, we aimed to evaluate the incidence, risk factors and consequences of preterm birth in Nepal. Methods: This was an observational study conducted in 12 public hospitals of Nepal. All the babies born during the study period were included in the study. Babies born <37 weeks of gestation were classified as preterm births. For the association and outcomes for preterm birth, univariate followed by multiple regression analysis was conducted. Results: The incidence of preterm was found to be 93 per 1000 live births. Mothers with age less than 20 years (aOR 1.21; 1.09-1.34) and 35 years and above (aOR 1.30; 1.05-1.63) had a high risk for preterm birth. Similarly, education of the mother was a significant predictor for preterm birth: illiterate mothers (aOR 1.90; 1.66-2.19), literate mothers (aOR 1.48; 1.33-1.65) and mothers having basic level of education (aOR 1.25; 1.14-1.38). Socio-demographic factors such as smoking (aOR 2.02; .84-2.22) and use of polluted fuel (aOR 1.38; 1.28-1.50); obstetric factors such as nulliparity (aOR 1.44; 1.28-1.61), multiple delivery (aOR 1.92; 1.33-2.76), severe anemia during pregnancy (aOR 2.43; 1.55-3.82), antenatal visit during second trimester (aOR 1.10; 1.02-1.19) and third trimester (aOR 1.44; 1.30-1.60) were found to be significant risk factors of preterm birth. Preterm has a risk for pre-discharge mortality (10.60; 9.28-12.10). Conclusion: In this study, we found high incidence of preterm birth. Various socio-demographic, obstetric and neonatal risk factors were associated with preterm birth. Risk factor modifications and timely interventions will help in the reduction of preterm births and associated mortalities.

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Gender and preterm birth: Is male fetal gender a clinically important risk factor for preterm birth in high-risk women?

Cited by 28 publications

References 13 publications

Outcome of late preterm newborns in Upper Egypt

Outcome of late preterm newborns in Upper Egypt

Incidence, risk factors and consequences of preterm birth – findings from a multicentric observational study in Nepal

Incidence, risk factors and consequences of preterm birth – findings from a multicentric observational study in Nepal

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