Gender and socioeconomic disparities in global burden of chronic kidney disease due to glomerulonephritis: A global analysis

Bai, Jiang; Yang, Jingyuan; Di, Jing-Kai; Shi, Yaru; Zhang, Jun-Rui; Zhou, Yun

doi:10.1111/nep.14137

Cited by 4 publications

(4 citation statements)

References 35 publications

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“…We further conducted the analysis on several risk factors for FSGS recurrence in children. The summary of the articles included in this study did not find the effect of gender on the recurrence of FSGS, and most studies also believed that gender would not affect the recurrence of FSGS 18,22,32 . What is more, the published study demonstrated that younger recipient age was found to be the most reliable predictors of recurrence of FSGS 18,25,33 .…”

Section: Discussionmentioning

confidence: 71%

“…The summary of the articles included in this study did not find the effect of gender on the recurrence of FSGS, and most studies also believed that gender would not affect the recurrence of FSGS. 18,22,32 What is more, the published study demonstrated that younger recipient age was found to be the most reliable predictors of recurrence of FSGS. 18,25,33 However, patients in another study who were older at the time of transplantation had a greater recurrence rate.…”

Section: Discussionmentioning

confidence: 94%

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Incidence, risk factors, and outcomes of recurrent focal segmental glomerulosclerosis in pediatric kidney transplant recipients: A systematic review and meta‐analysis

Bai,

Yin,

et al. 2023

Clinical Transplantation

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BackgroundFocal segmental glomerulosclerosis is the most prevalent acquired kidney disease leading to end‐stage renal disease in children and has a propensity for recurring in the transplanted kidney. The recurrence of FSGS after kidney transplantation in children varies greatly. In addition, the risk factors and outcomes of recurrence of FSGS remain controversial. This study evaluated the recurrence rate, risk factors, and prognosis of FSGS after kidney transplantation in order to provide advice and assistance in clinical decision‐making for pediatric kidney transplantation.MethodsPubMed, Embase, Web of Science, CNKI, and other databases were searched from the establishment of the repository to March 2022. We extracted data on incidence, risk factors, and outcomes.ResultsThe results showed that the recurrence rate of primary FSGS in children after renal transplantation was 48% (95% CI 36%–59%) and the recurrence rate of FSGS (all forms) was 35% (95% CI 17%–52%). The graft loss rate of primary FSGS in children after kidney transplantation was 29% (95% CI 17%–42%) and the graft loss rate of FSGS (all forms) was 29% (95% CI 4%–62%). 57% (95% CI 42%–73%) of pediatric patients with recurrent primary FSGS showed complete remission. Risk factor analyses showed that age of onset (SMD .69, 95% CI .20–1.19, p = .006) was related to the recurrence of primary FSGS, whereas the living related donor was not a risk factor for recurrent primary FSGS in pediatrics after kidney transplantation (OR 1.22, 95% CI .48–3.10, p = .674).ConclusionsThe recurrence rate and graft loss rate of FSGS in children after kidney transplantation were relatively high. Age at onset was associated with a risk for recurrent primary FSGS, whereas the living related donor was not a risk factor for recurrent FSGS in pediatric kidney recipients.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 94%

Incidence, risk factors, and outcomes of recurrent focal segmental glomerulosclerosis in pediatric kidney transplant recipients: A systematic review and meta‐analysis

Bai,

Yin,

et al. 2023

Clinical Transplantation

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“…Gender-specific risk factors may differ because of different lifestyles or sex differences in pathophysiology. In some studies, men had a higher burden of hypertension, obesity, or dietary sodium than females [ 75 , 111 ]. Smoking appears to be a risk factor for hyperkalemia only in men [ 112 ].…”

Section: Improving Outcomes For Women With Ckd and Cvdmentioning

confidence: 99%

Sex disparities in mortality and cardiovascular outcomes in chronic kidney disease

Balafa,

Fernandez-Fernandez,

Ortiz

et al. 2024

Clinical Kidney Journal

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Sex (biologically determined) and gender (socially constructed) modulate manifestations and prognosis of a vast number of diseases, including cardiovascular disease (CVD) and chronic kidney disease (CKD). CVD remains the leading cause of death in CKD patients. Population-based studies indicate that women present a higher prevalence of CKD and experience less CVD than men in all CKD stages, although this is not as clear in patients on dialysis or transplantation. When compared to the general population of the same sex, CKD has a more negative impact on women on kidney replacement therapy. European women on dialysis or recipients of kidney transplants have life expectancy up to 44.8 and 19.8 years lower, respectively, than their counterparts of similar age in the general population. For men, these figures stand at 37.1 and 16.5 years, representing a 21% to 20% difference, respectively. Hormonal, genetic, societal, and cultural influences may contribute to these sex-based disparities. To gain a more comprehensive understanding of these differences and their implications for patient care, well-designed clinical trials that involve a larger representation of women and focus on sex-related variables are urgently needed. This narrative review emphasizes the importance of acknowledging the epidemiology and prognosis of sex disparities in CVD among CKD patients. Such insights can guide research into the underlying pathophysiological mechanisms, leading to optimized treatment strategies and ultimately, improved clinical outcomes.

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“…The increasing prevalence of chronic kidney disease (CKD) is a signi cant public health concern, involving about 10% of the global population [1], 1 exceeding the number of cases observed in diabetes, chronic obstructive pulmonary disease, and depressive disorders. [2][3][4] Individuals with a family history of high cholesterol are predisposed to develop CKD, implicating the composition of circulating lipoproteins, particularly the lipid and protein components, in CKD development. 5 Furthermore, lipids and their metabolites are essential constituents of cell and organelle membranes, signaling molecules, and energy generators, in uencing structural and functional aspects 6 .…”

Section: Introductionmentioning

confidence: 99%

The Role of Remnant Cholesterol and Its Interaction with Low-Density Lipoprotein Cholesterol in Chronic Kidney Disease

Bai,

Dong,

Zhang

et al. 2024

Preprint

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Background The growing prevalence of chronic kidney disease (CKD) presents a substantial public health issue. Furthermore, the continuous advancements in lipid-lowering strategies and medications highlight the ongoing importance of the correlation between remnant cholesterol (RC) and CKD. This study aims to investigate the link between RC and CKD risk, particularly focusing on the interplay between low-density lipoprotein cholesterol (LDL-C) and RC. Methods This cross-sectional study included 7747 participants in wave 2009 of the China Health and Nutrition Survey which has been in progress since 1989. We enrolled 7747 individuals in the present study from the China Health and Nutrition Survey, with exclusion criteria applied to individuals under 18 and pregnant participants. CKD was defined as eGFR < 60 mL/min/1.73 m2, following the Kidney Disease: Improving Global Outcomes (KDIGO) 2012 Clinical Practice Guideline. A logistic regression analysis was conducted to assess the associations between discordant/concordant levels of LDL-C and RC with CKD. Subsequently, a mediation analysis was performed to identify potential mediators. Results Within the clinical cohort of 7747 patients, 910 individuals (11.8%) were diagnosed with CKD, with RC levels categorized into quartiles. Logistic analysis revealed significant associations between elevated RC levels and the prevalence of CKD (OR 1.30, 95% CI 1.06–1.60 for Group 2; OR 1.49, 95% CI 1.22–1.83 for Group 3; and OR 1.33, 95% CI 1.08–1.63 for Group 4). The results of restricted cubic splines (RCS) analysis suggested an “inverted U-shaped” association of RC with CKD. The analysis of discordant/concordant grouping showed that participants in Group 2 (high LDL-C/low RC) and Group 3 (low LDL-C/high RC) were associated with an increased risk for CKD. The odds ratios were 2.35 (95% CI 1.83–3.03) for Group 2 and 1.51 (95% CI 1.14–2.01) for Group 3, compared to Group 1 (low LDL-C/low RC). Causal mediation analysis indicated that inflammation partially mediated the association between RC and CKD. Conclusions This study presented evidence of a non-linear relationship between RC and CKD, suggesting that the association was influenced by LDL-C levels and mediated by the pro-inflammatory state.

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Gender and socioeconomic disparities in global burden of chronic kidney disease due to glomerulonephritis: A global analysis

Cited by 4 publications

References 35 publications

Incidence, risk factors, and outcomes of recurrent focal segmental glomerulosclerosis in pediatric kidney transplant recipients: A systematic review and meta‐analysis

Incidence, risk factors, and outcomes of recurrent focal segmental glomerulosclerosis in pediatric kidney transplant recipients: A systematic review and meta‐analysis

Sex disparities in mortality and cardiovascular outcomes in chronic kidney disease

The Role of Remnant Cholesterol and Its Interaction with Low-Density Lipoprotein Cholesterol in Chronic Kidney Disease

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