Gender‐associated differences in dyspnoea and health‐related quality of life in patients with chronic obstructive pulmonary disease

Katsura, Hideki; Yamada, Kazutoyo; Wakabayashi, Ritsuko; Kida, Kenji

doi:10.1111/j.1440-1843.2007.01075.x

Cited by 60 publications

(50 citation statements)

References 34 publications

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“…The finding that HRQL is worse in women is consistent with previous studies of using other HRQL instruments (3)(4)(5). Do factors determining quality of life in men and women differ; with mental state and symptoms playing a more dominant role in HRQL among women with COPD (42)?…”

Section: Discussionsupporting

confidence: 86%

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Co-Morbidity, Body Mass Index and Quality of Life in COPD Using the Clinical COPD Questionnaire

Sundh

Ställberg

Lisspers

et al. 2011

COPD: Journal of Chronic Obstructive Pulmonary Disease

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Section: Discussionsupporting

confidence: 86%

“…Previous studies have shown that HRQL in COPD is influenced by low physical capacity, a high level of dyspnoea and worsening of emotional state, but it is also associated with female sex, reduced lung function, older age, a history of heavy tobacco use and frequent exacerbations (3)(4)(5)(6)(7)(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Co-Morbidity, Body Mass Index and Quality of Life in COPD Using the Clinical COPD Questionnaire

Sundh

Ställberg

Lisspers

et al. 2011

COPD: Journal of Chronic Obstructive Pulmonary Disease

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“…20). Patient-based studies also indicate that women with cardiopulmonary conditions have greater respiratory symptoms and exercise intolerance compared to men (120,267). The mechanisms underlying the perception of breathlessness remain unclear, and how sex-based differences in sensory input modulate the dyspnea sensations are unknown.…”

Section: The Healthy Older Femalementioning

confidence: 93%

Ventilation and Respiratory Mechanics

Sheel

Romer

2012

Comprehensive Physiology

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During dynamic exercise, the healthy pulmonary system faces several major challenges, including decreases in mixed venous oxygen content and increases in mixed venous carbon dioxide. As such, the ventilatory demand is increased, while the rising cardiac output means that blood will have considerably less time in the pulmonary capillaries to accomplish gas exchange. Blood gas homeostasis must be accomplished by precise regulation of alveolar ventilation via medullary neural networks and sensory reflex mechanisms. It is equally important that cardiovascular and pulmonary system responses to exercise be precisely matched to the increase in metabolic requirements, and that the substantial gas transport needs of both respiratory and locomotor muscles be considered. Our article addresses each of these topics with emphasis on the healthy, young adult exercising in normoxia. We review recent evidence concerning how exercise hyperpnea influences sympathetic vasoconstrictor outflow and the effect this might have on the ability to perform muscular work. We also review sex-based differences in lung mechanics.

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“…This is an unexpected result because the association between lung function and HRQL is considered to be weak. 38,39 Since female COPD patients tend to report a lower HRQL than males 40 and the psychological distress in COPD patients is found to be associated with HRQL, 41 one might have expected stronger influence from gender, anxiety and depression in the regression model. Our result, however, suggests that a lung function above a certain level may be crucial in order to deal with symptoms, perform physical activities and reduce the psychosocial strains of the disease.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary rehabilitation reduces depression and enhances health-related quality of life in COPD patients - especially in patients with mild or moderate disease

et al. 2010

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The first objective of the study was to evaluate a 4-week inpatient pulmonary rehabilitation program on exercise capacity, health-related quality of life (HRQL) and psychological distress in patients with COPD. The second objective was to investigate the influence of gender, age, disease severity, co-morbidity, anxiety and depression on improved HRQL after rehabilitation. The study comprised 136 consecutive patients from baseline to follow-up with mild-to-severe COPD. Exercise capacity was measured by the 6-min walking distance test, disease severity by spirometric tests, HRQL by The St. George's Respiratory Questionnaire and psychological distress by the The Hospital Anxiety and Depression Scale. Variables on socio-demography and co-morbidity were self-reported. Exercise capacity was improved from baseline to follow-up with a score difference of þ44 metres (p ¼ 000). Except for the activity score, HRQL was significantly improved: a change of -3.5 for the symptom score (p ¼ 014), -3.1 for the total score (p ¼ 003) and a clinical significant change of -4.0 for the impact score (p ¼ 002). The anxiety score did not change significantly after rehabilitation (-0.1, p ¼ 545), though there was a significant reduction of the depression score (-0.8, p ¼ 002) and a 10.4% reduction in the prevalence of possible depression cases (p ¼ 017). Patients with forced expiratory volume in 1 second 50% predicted were 4.2 times more likely to achieve a clinical significant improved HRQL after rehabilitation than patients with forced expiratory volume in 1 second <50% predicted (95% confidence interval [CI] 1.7-10.3, p ¼ 002). A 4-week inpatient rehabilitation program improves HRQL and exercise capacity and reduces depression in COPD patients. Patients with mild or moderate disease are more likely to achieve an improved HRQL after rehabilitation than patients with severe or very severe disease.

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Gender‐associated differences in dyspnoea and health‐related quality of life in patients with chronic obstructive pulmonary disease

Abstract: Gender differences exist in dyspnoea and HRQoL in patients with COPD. These need to be considered when designing treatment strategies for COPD patients.

Cited by 60 publications

References 34 publications

Co-Morbidity, Body Mass Index and Quality of Life in COPD Using the Clinical COPD Questionnaire

Co-Morbidity, Body Mass Index and Quality of Life in COPD Using the Clinical COPD Questionnaire

Ventilation and Respiratory Mechanics

Pulmonary rehabilitation reduces depression and enhances health-related quality of life in COPD patients - especially in patients with mild or moderate disease

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