Gender-Based Differences in Outcome in Patients With Sepsis

Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortality

“…Table 2 present the characteristics of identified studies of the incidence, prevalence and mortality rate of sepsis at the population level. All the studies reported their own original results based on hospital findings with a clearly defined credible population denominator which in some cases has been used to produce the national estimates that the studies reported [9,10,[13][14][15][16][17][18][19][20][21][22][23][24][25].…”

Sex-and age-based differences in the delivery and outcomes of critical care

“…However, a consistent relation between critical illness and sex, immunologic response and clinical outcomes has not been established. 23,35,36 Different estrogen or other sexrelated hormone levels and unique cytokine responses among younger and older men and women may explain in part the difference in mortality we observed. 37 However, critical illness comprises a broad range of complex underlying conditions, and it is unlikely that a single or even a few simple sex-related biological differences apply equally and in all circumstances.…”

“…This age-sex relation is consistent with findings from smaller studies. 4,23 In previous studies, sex-related differences in outcomes among critically ill patients receiving mechanical ventilation were attenuated after adjustment for severity of illness;…”

“…32,33 It may also influence susceptibility to immunologic disorders and responses to severe infections and sepsis. 23,34 These factors may explain differential outcomes of critical illness. However, a consistent relation between critical illness and sex, immunologic response and clinical outcomes has not been established.…”

Female Gender and Patient Outcomes Female Gender... Is It Really A Risk Or A Boon?

“…[7] Crticial Care Long back in 1999, Eachempati et al reported female gender as an important risk factor for increased mortality in critically ill patients with documented infection. [8] The same scenario prevailed even after 10 years of established health care systems. [9] But in 2010, a study by Akgun et al reported no effect of gender on health care in older medical intensive care patients, as tested by The Therapeutic Intervention Scoring System-28 [10] .…”