Gender-based normative values for pattern-reversal and flash visually evoked potentials under binocular and monocular stimulation in healthy adults

Dotto, Patrícia de Freitas; Berezovsky, Adriana; Sacai, Paula Yuri; Rocha, Daniel; Salomão, Solange Rios

doi:10.1007/s10633-017-9594-x

Cited by 19 publications

(13 citation statements)

References 48 publications

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“…Correlations between conditions for these measures, however, were even higher than those obtained for the peak time measures. The amplitude and peak time values reported here in Table 1 for the 1-min condition match closely the corresponding values collected under similar ISCEV-standard conditions (Odom et al, 2016) in a recent study (de Freitas Dotto, Berezovsky, Sacai, Rocha, & Salomão, 2017). An example of a tVEP-CR waveform obtained under the short-duration condition is depicted in Figure 8a.…”

Section: Waveform Analysissupporting

confidence: 84%

Quantification and statistical analysis of the transient visual evoked potential to a contrast‐reversing pattern: A frequency‐domain approach

Zemon

Gordon

2018

Eur J of Neuroscience

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Visual function is often assessed by recording transient visual evoked potentials to contrast reversal of spatial patterns (tVEP-CR). This technique relies on measurements of amplitudes and peak times of a few points in the time-domain waveform, which require subjective selection of appropriate time points in a possibly noisy waveform and ignores much of the informational content in the response. Here, we introduce a set of frequency-domain measures that capture the full content of the response. Magnitude-squared coherence is used to determine the significance and reliability of magnitude measures; estimates of time delay are based on frequency-domain phase measures. In Study 1, extensive testing of a small number of observers revealed response details, and in Study 2, testing of a larger sample verified the novel frequency-domain measures and demonstrated the validity of a short-duration technique to produce reliable tVEP-CRs. In addition, Study 2 revealed adaptation effects present under prolonged stimulation conditions. Principal component analyses provided evidence for six distinct frequency mechanisms, and comparisons with time-domain measures indicated that power in high-frequency bands may be used as objective measures of excitatory input to visual cortex. A middle-frequency band captures the major peaks in the tVEP-CR waveform, and its power is highly correlated with the standard peak-to-trough amplitude measure. These novel frequency-domain indices may serve as more precise and powerful tools to assess visual function in healthy and diseased states.

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Section: Waveform Analysissupporting

confidence: 84%

Quantification and statistical analysis of the transient visual evoked potential to a contrast‐reversing pattern: A frequency‐domain approach

Zemon

Gordon

2018

Eur J of Neuroscience

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“…Gender differences in VEP peak times and amplitudes have been reported in humans . In our study, the total number of males was too small (nine males, evenly distributed across the evaluated age span from 44 hours to 28 years) to make meaningful comparisons between genders and to assess gender effects in the equine FVEP.…”

Section: Discussioncontrasting

confidence: 61%

Age‐associated changes in the equine flash visual evoked potential

Ström

Michanek²,

Ekesten

2018

Veterinary Ophthalmology

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The overall equine FVEP waveform was similar across the normal life-span of the horse in our cross-sectional study. We found that the visual system of the foal seems to be well developed already at birth. Furthermore, our results showed a decrease in amplitudes and increase in some peak times with increasing age. We recommend that age-matched controls should be used when evaluating foals and young horses in clinical practice, whereas horses over the age of three years can be compared to other adult horses.

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“…Peak times were measured for P100 in milliseconds (ms). Amplitudes were classified as normal or reduced and P100 peak times as normal or delayed in relation to normative cutoffs obtained from normal values of our own laboratory (55).…”

Section: Visual Electrophysiological Assessmentmentioning

confidence: 99%

Impaired Ganglion Cell Function Objectively Assessed by the Photopic Negative Response in Affected and Asymptomatic Members From Brazilian Families With Leber's Hereditary Optic Neuropathy

et al. 2021

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Purpose: The photopic negative response (PhNR) is an electrophysiological method that provides retinal ganglion cell function assessment using full-field stimulation that does not require clear optics or refractive correction. The purpose of this study was to assess ganglion cell function by PhNR in affected and asymptomatic carriers from Brazilian families with LHON.Methods: Individuals either under suspicion or previously diagnosed with LHON and their family members were invited to participate in this cross-sectional study. Screening for the most frequent LHON mtDNA mutations was performed. Visual acuity, color discrimination, visual fields, pattern-reversal visual evoked potentials (PRVEP), full-field electroretinography and PhNR were tested. A control group of healthy subjects was included. Full-field ERG PhNR were recorded using red (640 nm) flashes at 1 cd.s/m2, on blue (470 nm) rod saturating background. PhNR amplitude (μV) was measured using baseline-to-trough (BT). Optical coherence tomography scans of both the retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) were measured. PhNR amplitudes among affected, carriers and controls were compared by Kruskal-Wallis test followed by post-hoc Dunn test. The associations between PhNR amplitude and OCT parameters were analyzed by Spearman rank correlation.Results: Participants were 24 LHON affected patients (23 males, mean age=30.5 ± 11.4 yrs) from 19 families with the following genotype: m.11778G>A [N = 15 (62%), 14 males]; m.14484T>C [N = 5 (21%), all males] and m.3460G>A [N = 4 (17%), all males] and 14 carriers [13 females, mean age: 43.2 ± 13.3 yrs; m.11778G>A (N = 11); m.3460G>A (N = 2) and m.14484T>C (N = 1)]. Controls were eight females and seven males (mean age: 32.6 ± 11.5 yrs). PhNR amplitudes were significantly reduced (p = 0.0001) in LHON affected (−5.96 ± 3.37 μV) compared to carriers (−16.53 ± 3.40 μV) and controls (−23.91 ± 4.83; p < 0.0001) and in carriers compared to controls (p = 0.01). A significant negative correlation was found between PhNR amplitude and total macular ganglion cell thickness (r = −0.62, p < 0.05). Severe abnormalities in color discrimination, visual fields and PRVEPs were found in affected and subclinical abnormalities in carriers.Conclusions: In this cohort of Brazilian families with LHON the photopic negative response was severely reduced in affected patients and mildly reduced in asymptomatic carriers suggesting possible subclinical abnormalities in the latter. These findings were similar among pathogenic mutations.

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Gender-based normative values for pattern-reversal and flash visually evoked potentials under binocular and monocular stimulation in healthy adults

Cited by 19 publications

References 48 publications

Quantification and statistical analysis of the transient visual evoked potential to a contrast‐reversing pattern: A frequency‐domain approach

Quantification and statistical analysis of the transient visual evoked potential to a contrast‐reversing pattern: A frequency‐domain approach

Age‐associated changes in the equine flash visual evoked potential

Impaired Ganglion Cell Function Objectively Assessed by the Photopic Negative Response in Affected and Asymptomatic Members From Brazilian Families With Leber's Hereditary Optic Neuropathy

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