2021
DOI: 10.21203/rs.3.rs-252094/v1
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Gender difference in arsenic biotransformation is an important metabolic basis for arsenic toxicity

Abstract: Background: There are gender differences in the biotransformation of arsenic. We investigated the effects of gender differences on arsenic metabolism and arsenic toxicity mechanisms in rat liver tissues. Methods: Rats were treated with different amounts of arsenic compounds. Arsenic form MMA and DMA in the liver was determined by high performance liquid chromatography-hydride generation atomic fluorescence spectroscopy. SAM, ARR, NAD, PNP, PK, and MPO in rat liver were determined by enzyme-linked immunoassay. … Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2023
2023
2023
2023

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
(1 citation statement)
references
References 29 publications
0
1
0
Order By: Relevance
“…As the concentrations of As(V) and MMA in female rats were higher than in males, the differences in arsenic distribution may be the cause of the differences in liver response. Although it is not clear why As(V) and MMA concentrations were higher in female rats than in males, it might be due to sex differences in arsenic metabolism, such as higher methylation capacity, which metabolizes As(III) to MMA, and lower purine nucleoside phosphorylase (PNP) activity, which reduces As(V) to As(III), in female rats than in males 26 .…”
Section: Discussionmentioning
confidence: 99%
“…As the concentrations of As(V) and MMA in female rats were higher than in males, the differences in arsenic distribution may be the cause of the differences in liver response. Although it is not clear why As(V) and MMA concentrations were higher in female rats than in males, it might be due to sex differences in arsenic metabolism, such as higher methylation capacity, which metabolizes As(III) to MMA, and lower purine nucleoside phosphorylase (PNP) activity, which reduces As(V) to As(III), in female rats than in males 26 .…”
Section: Discussionmentioning
confidence: 99%