Gender difference in association between diabetes mellitus and all-cause mortality in atrial fibrillation patients

Li, Tian; Yang, Yanmin; Zhang, Han; Shao, Xing‐hui

doi:10.1016/j.jdiacomp.2022.108265

Journal of Diabetes and its Complications

2022

DOI: 10.1016/j.jdiacomp.2022.108265

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Gender difference in association between diabetes mellitus and all-cause mortality in atrial fibrillation patients

Tian Li

Yanmin Yang

Han Zhang

et al.

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2024

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Cited by 2 publications

References 24 publications

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Differential Effect of Sex on Mortality According to Age in Heart Failure

Lee,

Yoon,

Choi

et al. 2024

JAHA

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Background Heart failure exhibits sex‐based differences in prevalence, clinical characteristics, and outcomes. However, these differences may have an interaction with age. This study investigates these disparities in Asian patients with acute heart failure according to age. Methods and Results We pooled data from the KorHF (Korea Heart Failure) and the KorAHF (Korean Acute Heart Failure) registries including 3200 patients between 2005 and 2009 and 5625 patients between 2011 and 2014, respectively, hospitalized for acute heart failure in Korea. Patients were categorized by their age into 2 groups: those with age ≥70 years and those with age <70 years. The primary endpoint was in‐hospital and postdischarge outcomes according to sex, stratified by age. Of 8825 patients, 45.7% had an age <70 years, and 54.3% had an age ≥70 years. Women were older on average in both groups. Differences in baseline characteristics were more apparent in the older group, with women having a higher prevalence of hypertension and valvular heart disease, whereas more men had chronic kidney disease, previous myocardial infarction, chronic obstructive pulmonary disease, and strokes. Both in‐hospital and postdischarge mortalities showed differences only in the older group, with men dying more (5.08% versus 7.41%, P <0.001; 17.95% versus 22.20%, P <0.001 respectively). This pattern persisted to adjusted analyses, which revealed that men have a 54% (odds ratio, 1.54 [95% CI, 1.17–2.04]) and 30% (hazard ratio, 1.30 [95% CI, 1.13–1.51]) increased in‐hospital and 1‐year mortality, respectively, compared with women. Conclusions In patients hospitalized with acute heart failure, male sex is an independent predictor of mortality in older patients but not younger patients.

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Differential Effect of Sex on Mortality According to Age in Heart Failure

Lee,

Yoon,

Choi

et al. 2024

JAHA

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Risk of Death From Various Causes According to Prevalent Atrial Fibrillation: A Nationwide Population-Based Study

Kim,

Lee,

Choi

et al. 2024

J Korean Med Sci

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Background Atrial fibrillation (AF) is associated with increased risks of adverse events including stroke and all-cause death. Understanding the pattern of causes of death (COD) with the relative risks in patients with AF compared to the non-AF population is essential in planning optimal care for patients with AF. We aimed to analyze the COD and its relative risks in patients with AF, using a nationwide population-based cohort. Methods Using the Korean nationwide claims database, people aged 40 or older who received health examinations in 2009 were included if they had no missing values (n = 6,877,929). In total the study included 40,585 people with AF and 6,837,344 without AF. COD was defined by International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) diagnostic codes. Comparison between the AF and non-AF groups was performed with Multivariate Cox proportional regression model. Results In the AF group, cardiovascular diseases were the most common COD, causing 39.8% of all deaths, compared with 19.0% for non-AF subjects. The AF group was associated with a higher risk of death from cardiovascular and cerebrovascular diseases by almost 3-fold than the matched non-AF group (hazard ratios [HR], 3.082; 95% confidence intervals [CIs], 2.963–3.205 for cardiovascular diseases; HR, 2.981; 95% CI, 2.799–3.175 for cerebrovascular diseases, all P < 0.001). Among patients with AF, the risks of all-cause, cardiovascular, and cerebrovascular death were well-stratified by CHA 2 DS 2 -VASc scores. The risk of cerebrovascular death was 11 times higher among patients with a CHA 2 DS 2 -VASc score ≥ 7. Conclusion Compared to non-AF individuals, patients with AF had a higher risk of death from cardiovascular and cerebrovascular diseases, and the mortality risks were well-stratified by the CHA 2 DS 2 -VASc score. Integrated care management of cardiovascular and cerebrovascular diseases for patients with AF might help mitigate mortality.

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Gender difference in association between diabetes mellitus and all-cause mortality in atrial fibrillation patients

Cited by 2 publications

References 24 publications

Differential Effect of Sex on Mortality According to Age in Heart Failure

Differential Effect of Sex on Mortality According to Age in Heart Failure

Risk of Death From Various Causes According to Prevalent Atrial Fibrillation: A Nationwide Population-Based Study

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