Gender Differences Among Patients with Secondary Hyperparathyroidism Undergoing Parathyroidectomy

Cheng, Shih‐Ping; Yang, Tsen-Long; Lee, Jie-Jen; Chen, Han‐Hsiang; Wu, Chih‐Jen; Liu, Tsang-Pai; Liu, Chien-Liang

doi:10.1016/j.jss.2009.07.034

Cited by 23 publications

(19 citation statements)

References 27 publications

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“…In addition, the inverse relation between perchlorate and PTH was observed mainly in women. Our previous study suggested that different target organ susceptibility to hyperparathyroidism may exist in different genders [34] . On the other hand, gender difference may have some impacts on PTH levels.…”

Section: Discussionmentioning

confidence: 99%

Negative Association between Serum Parathyroid Hormone Levels and Urinary Perchlorate, Nitrate, and Thiocyanate Concentrations in U.S. Adults: The National Health and Nutrition Examination Survey 2005–2006

Liu

Lee

et al. 2014

PLoS ONE

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ObjectivesPerchlorate, nitrate, and thiocyanate are well-known inhibitors of the sodium-iodide symporter and may disrupt thyroid function. This exploratory study investigated the association among urinary perchlorate, nitrate, and thiocyanate concentrations and parathyroid hormone (PTH) levels in the general U.S. population.MethodsWe analyzed data on 4265 adults (aged 20 years and older) from the National Health and Nutrition Examination Survey in 2005 through 2006 to evaluate the relationship among urinary perchlorate, nitrate, and thiocyanate concentration and PTH levels and the presence of hyperparathyroidism cross-sectionally.ResultsThe geometric means and 95% confidence interval (95% CI) concentrations of urinary perchlorate, nitrate, and thiocyanate were 3.38 (3.15–3.62), 40363 (37512–43431), and 1129 (1029–1239) ng/mL, respectively. After adjusting for confounding variables and sample weights, creatinine-corrected urinary perchlorate was negatively associated with serum PTH levels in women (P = 0.001), and creatinine-corrected urinary nitrate and thiocyanate were negatively associated with serum PTH levels in both sex groups (P = 0.001 and P<0.001 for men, P = 0.018 and P<0.001 for women, respectively). Similar results were obtained from sensitivity analyses performed for exposure variables unadjusted for creatinine with urinary creatinine added as a separate covariate. There was a negative relationship between hyperparathyroidism and urinary nitrate and thiocyanate [odds ratio (95% CI) = 0.77 (0.60–0.98) and 0.69 (0.61–0.79), respectively].ConclusionsA higher urinary concentration of perchlorate, nitrate, and thiocyanate is associated with lower serum PTH levels. Future studies are needed to determine the pathophysiological background of the observation.

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Section: Discussionmentioning

confidence: 99%

Negative Association between Serum Parathyroid Hormone Levels and Urinary Perchlorate, Nitrate, and Thiocyanate Concentrations in U.S. Adults: The National Health and Nutrition Examination Survey 2005–2006

Liu

Lee

et al. 2014

PLoS ONE

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“…A more aggressive histological pattern has been shown in female compared with male patients undergoing PTX for sHPT [ 25 ]. Furthermore, Cheng et al [ 26 ] found a worse bone mineral metabolism prior PTX in women than in men. Thus, women seem to suffer from more severe sHPT than men, which left untreated may carry a greater risk of hip fracture.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Parathyroidectomy on Risk of Hip Fracture in Secondary Hyperparathyroidism

et al. 2017

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Background Secondary hyperparathyroidism increases the risk for fractures. Despite improvement in medical therapy, surgical parathyroidectomy (PTX) often becomes necessary, but its effect on risk of fractures is not clear. Our aim was to study the effect of parathyroidectomy on the risk of hip fractures in patients on dialysis or with a functioning renal graft at time of parathyroidectomy. DesignIn a cohort of 20,056 patients on dialysis or with functioning renal allograft, we identified 590 patients who underwent parathyroidectomy between 1991 and 2009. Of these, 579 were matched with 1970 non-PTX patients on age, sex, cause of renal disease and functioning renal allograft or not at the time of PTX or at the corresponding time for non-PTX patients (t). We calculated the risk for hip fracture after PTX using crude and adjusted Cox proportional hazards regressions, adjusting for time in renal replacement therapy before t, time with functioning renal allograft before and after t, comorbidity at t and a hip fracture before t.ResultsThe adjusted hazard ratio (95% confidence interval) for hip fracture was 0.40 (0.18–0.88) for PTX patients, compared to non-PTX patients. When analyses were performed separately for sex, only women had a lower risk of hip fracture after PTX compared to non-PTX patients. The risk of hip fracture after PTX was similar in patients with or without functioning renal allograft at time for PTX.ConclusionParathyroidectomy is associated with a lower risk of hip fracture in female patients with secondary hyperparathyroidism.

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“…We also thank our editors and associate editors for their critical contributions to the Journal, both in editorial and scientific purposes [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47]. We thank our colleagues at Elsevier and Stellar Medical Publications for their invaluable contributions to the Journal, both scientifically and editorially.…”

Section: Acknowledgmentsmentioning

confidence: 92%

The Journal of Surgical Research – 2012

McFadden

Souba²

2012

Journal of Surgical Research

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Gender Differences Among Patients with Secondary Hyperparathyroidism Undergoing Parathyroidectomy

Cited by 23 publications

References 27 publications

Negative Association between Serum Parathyroid Hormone Levels and Urinary Perchlorate, Nitrate, and Thiocyanate Concentrations in U.S. Adults: The National Health and Nutrition Examination Survey 2005–2006

Negative Association between Serum Parathyroid Hormone Levels and Urinary Perchlorate, Nitrate, and Thiocyanate Concentrations in U.S. Adults: The National Health and Nutrition Examination Survey 2005–2006

The Effect of Parathyroidectomy on Risk of Hip Fracture in Secondary Hyperparathyroidism

The Journal of Surgical Research – 2012

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