Gender differences in adiponectin levels and body composition in older adults: Hallym aging study

Song, Hong Ji; Oh, Sohee; Quan, Shanai; Ryu, Ohk Hyun; Jeong, Jinyoung; Hong, Kyung-Soon; Kim, Dong-Hyun

doi:10.1186/1471-2318-14-8

Cited by 56 publications

(40 citation statements)

References 35 publications

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“…Previous work in the cardiovascular field supports our finding that peripheral CRP (Cartier et al, 2009; Khera et al, 2005; Lakoski et al, 2006; McConnell et al, 2002; Wener et al, 2000;), leptin (Couillard et al, 1997; Hellström et al, 2000; Hickey et al, 1996; Kennedy et al, 1997; Ostlund et al, 1996), and adiponectin levels (Böttner et al, 2004; Saltevo et al, 2009; Song et al, 2014) are naturally higher in women compared to men, independent of age, race, and body mass index. Our study expands these findings in demonstrating that other inflammatory markers, such as TNF, are also higher in women than in men.…”

Section: Discussionsupporting

confidence: 88%

“…In healthy individuals, it has been demonstrated that peripheral levels of CRP (Cartier et al, 2009; Khera et al, 2005; Lakoski et al, 2006; McConnell et al, 2002, Wener et al, 2000), leptin (Couillard et al, 1997, Hellström et al, 2000; Hickey et al, 1996; Kennedy et al, 1997; Ostlund et al, 1996), and adiponectin (Böttner et al, 2004; Saltevo et al, 2009; Song et al, 2014) are naturally higher in women compared to men, independent of age, race, and body mass index. Despite this, although most studies of sleep apneics statistically control for gender in their analyses, very few have expressly investigated possible gender differences in inflammation.…”

Section: Introductionmentioning

confidence: 99%

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Gender differences in the association of sleep apnea and inflammation

Gaines

Vgontzas

Fernández-Mendoza

et al. 2015

Brain, Behavior, and Immunity

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Over the last 15 years, many studies have established an association of sleep apnea with inflammation and metabolic aberrations. However, no controlled studies have examined potential gender effects in this association. We recruited 120 middle-aged, predominantly non-obese mild-to-moderate sleep apneics and controls (62 males, 58 females). All participants underwent a clinical history, physical examination, and 1-night 8-hour polysomnography recording and provided a single fasting blood sample for assessment of interleukin-6 (IL-6), tumor necrosis factor receptor 1 (TNFR1), C-reactive protein (CRP), leptin, and adiponectin levels. Among non-sleep apneics, females had higher levels of TNFR1 (p = 0.01), CRP (p = 0.005), leptin (p < 0.001), and adiponectin (p < 0.001) compared to males, independent of age and body mass index. When analyzed separately by gender, sleep apneic men had elevated TNFR1 (p = 0.04), CRP (p = 0.06) and IL-6 (p = 0.11) relative to control men; in sleep apneic females, only CRP was elevated (p = 0.04). Furthermore, CRP was associated with apnea severity dose-response manner (p-linear = 0.04 in both genders) and was an independently associated with comorbid hypertension in apnea (p-linear = 0.005 for women; p-linear = 0.09 for men). In conclusion, although women have naturally higher levels of inflammatory and metabolic markers than men, sleep apneic men appear to have a more severe inflammatory profile compared to women. Our findings suggest that these markers should be analyzed and interpreted separately in men and women, and that a single measure of plasma CRP appears to be a clinically-useful marker of apnea severity and comorbid cardiovascular morbidity.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Gender differences in the association of sleep apnea and inflammation

Gaines

Vgontzas

Fernández-Mendoza

et al. 2015

Brain, Behavior, and Immunity

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“…In older populations, a higher adiponectin concentration was associated with a greater risk of cardiovascular disease, stroke and mortality. However, other authors have found no association between adiponectin and the risk of stroke [46] . Leptin is an adipokine that is now considered to control lipoprotein function, acute phase reactants, glucocorticoid metabolism, inflammation, immune function and reproduction and, hence, is key to integrating adipose tissue with competing biological functions [47] .…”

Section: Acta Pharmacologica Sinica Npgmentioning

confidence: 94%

Non-steroidal anti-inflammatory drugs attenuate the vascular responses in aging metabolic syndrome rats

et al. 2014

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Aim: Metabolic syndrome (MS) and aging are low-grade systemic inflammatory conditions, and inflammation is a key component of endothelial dysfunction. The aim of this study was to investigate the effects of non-steroidal anti-inflammatory drugs (NSAIDs) upon the vascular reactivity in aging MS rats. Methods: MS was induced in young male rats by adding 30% sucrose in drinking water over 6, 12, and 18 months. When the treatment was finished, the blood samples were collected, and aortas were dissected out. The expression of COX isoenzymes and PLA 2 in the aortas was analyzed using Western blot analysis. The contractile responses of aortic rings to norepinephrine (1 μmol/L) were measured in the presence or absence of different NSAIDs (10 μmol/L for each).Results: Serum levels of pro-inflammatory cytokines (IL-6, TNF-α, and IL-1β) in control rats were remained stable during the aging process, whereas serum IL-6 in MS rats were significantly increased at 12 and 18 months. The levels of COX isoenzyme and PLA 2 in aortas from control rats increased with the aging, whereas those in aortas from MS rats were irregularly increased with the highest levels at 6 months. Pretreatment with acetylsalicylic acid (a COX-1 preferential inhibitor), indomethacin (a non-selective COX inhibitor) or meloxicam (a COX-2 preferential inhibitor) decreased NE-induced contractions of aortic rings from MS rats at all the ages, with meloxicam being the most potent. Acetylsalicylic acid also significantly reduced the maximum responses of ACh-induced vasorelaxation of aortic rings from MS rats, but indomethacin and meloxicam had no effect. Conclusion: NSAIDs can directly affect vascular responses in aging MS rats. Understanding the effects of NSAIDs on blood vessels may improve the treatment of cardiovascular diseases and MS in the elders.

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“…Changes in RBC counts, Hb levels, and hematocrit (Hct) levels (erythroid-related variables) were compared between each group and each subgroup. We performed all analyses on the basis of sex, owing to physiological sex-related differences [1,22]; RBC counts, Hb levels, and Hct levels are significantly higher in men than in women, whereas adiponectin levels are significantly lower.…”

Section: Methodsmentioning

confidence: 99%

High Serum Adiponectin Level Is a Risk Factor for Anemia in Japanese Men: A Prospective Observational Study of 1,029 Japanese Subjects

et al. 2016

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Erythroid abnormalities including anemia and polycythemia are often observed in the general clinical setting. Because recent studies reported that adiponectin negatively affects hematopoiesis, we performed a prospective observational study to assess the relationship between anemia and adiponectin, as well as other parameters, in 1029 Japanese subjects (477 men and 552 women) 40 years of age and older. Body measurements, blood tests, and nutrition intake studies were performed at baseline, and 5 to 7 years later (follow-up). Hemoglobin (Hb) and hematocrit (Hct) levels in men with high serum adiponectin levels were lower at follow-up than at baseline. Multiple regression analysis showed that age, body mass index, adiponectin, and glutamic-pyruvic transaminase were significantly associated with erythroid-related variables (red blood cells, Hb, and Hct) in both men and women (P <0.05). In a logistic regression analysis, adiponectin, fasting blood glucose, and β-natriuretic peptide were significant risk factors for anemia in men, and blood urea nitrogen and amylase were significant risk factors in women. Physical features and nutrient intake were not risk factors for anemia. Our study demonstrates, both clinically and epidemiologically, that a high serum adiponectin level decreases the amounts of erythroid-related variables and is a risk factor for anemia in Japanese men.

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Gender differences in adiponectin levels and body composition in older adults: Hallym aging study

Cited by 56 publications

References 35 publications

Gender differences in the association of sleep apnea and inflammation

Gender differences in the association of sleep apnea and inflammation

Non-steroidal anti-inflammatory drugs attenuate the vascular responses in aging metabolic syndrome rats

High Serum Adiponectin Level Is a Risk Factor for Anemia in Japanese Men: A Prospective Observational Study of 1,029 Japanese Subjects

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