Gender differences in bipolar disorder: retrospective data from the first 500 STEP‐BD participants

Baldassano, Claudia F.; Marangell, Lauren B.; Gyulai, Laszlo; Ghaemi, S. Nassir; Joffe, Hadine; Kim, Deborah R.; Sagduyu, Kemal; Truman, Christine J; Wisniewski, Stephen R.; Sachs, Gary S.; Cohen, Lee S.

doi:10.1111/j.1399-5618.2005.00237.x

Cited by 129 publications

(107 citation statements)

References 19 publications

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“…Bipolar women (both I and II) are nearly twice as likely to have PTSD compared to bipolar men (20.9% vs. 10.6% in the STEP-BD study) [41], which is similar to the general population [14].…”

Section: Post-traumatic Stress Disorder (Ptsd)mentioning

confidence: 94%

Comorbid Anxiety in Bipolar Disorder Alters Treatment and Prognosis

El‐Mallakh

Hollifield

2008

Psychiatr Q

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Mood disorders in general, and bipolar disorder in particular, are unique among the psychiatric conditions in that they are associated with extraordinarily high rates of comorbidity with a multitude of psychiatric and medical conditions. Among all the potential comorbidities, co-occurring anxiety disorders stand out due to their very high prevalence. Outcome in bipolar illness is worse in the presence of a comorbid anxiety disorder. The coexistence of an anxiety disorder presents a particularly difficult challenge in the treatment of bipolar illness since antidepressants, the mainstay of pharmacologic treatments for anxiety, may adversely alter the course of manic-depression. Identification of anxiety disorders in bipolar patients is important. The treatment plan needs to balance the potential benefit and harm of antidepressant administration.

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“…Bipolar women (both I and II) are nearly twice as likely to have PTSD compared to bipolar men (20.9% vs. 10.6% in the STEP-BD study) [41], which is similar to the general population [14].…”

Section: Post-traumatic Stress Disorder (Ptsd)mentioning

confidence: 94%

Comorbid Anxiety in Bipolar Disorder Alters Treatment and Prognosis

El‐Mallakh

Hollifield

2008

Psychiatr Q

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“…This was done in order to examine the unique contribution of primary anxiety disorders to variance in BD. Analyses were conducted separately for males and females owing to the known gender differences in comorbidity in BD (Hendrik et al, 2000;Baldassano et al, 2005). Moreover, a preliminary logistic regression analysis confirmed that there was a significant interaction between gender and youth-onset anxiety as it relates to predicting BD (χ2=6.9, df=1, p=0.009).…”

Section: Statistical Analysesmentioning

confidence: 99%

Prevalence and correlates of bipolar I disorder among adults with primary youth‐onset anxiety disorders

Goldstein

Levitt

2007

Journal of Affective Disorders

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Objectives-It is of potentially great public health importance to determine whether youth-onset anxiety disorders are associated with increased prevalence of subsequent bipolar I disorder (BD) among adults, and to identify risk factors for BD in this population. Methods-The 2001-2002National Epidemiologic Survey on Alcohol and Related Conditions was used to identify respondents with social phobia, panic disorder, or generalized anxiety disorder that onset in youth (<19 years) and was not preceded by a major depressive, manic, or mixed episode (N=1,571; 572 males, 999 females). The prevalence of BD among subjects with, versus without, these youth-onset anxiety disorders was examined. Variables that could be associated with increased risk of BD among subjects with youth-onset anxiety disorders were examined, including conduct disorder, youth-onset substance use disorders (SUD), and family history of depression and/or alcoholism. Analyses were computed separately for males and females.Results-The prevalence of BD was significantly greater among adults with, versus without, primary youth-onset anxiety disorders for both males (15.9% vs 2.7%; χ2=318.4, df=1, p<0.001) and females (13.8% vs 2.9%; χ2=346.2, df=1, p<0.001). Youth-onset anxiety disorders remained significantly associated with BD after controlling for interceding major depression, and this was true for each of the specific anxiety disorders examined. Among males with youth-onset primary anxiety disorders, conduct disorder and loaded family history of depression were associated with significantly increased risk of BD. Among females, conduct disorder and loaded family history of alcoholism were associated with significantly increased risk of BD.Conclusions-The prevalence of BD was elevated among subjects with youth-onset primary anxiety disorders, particularly if comorbid conduct disorder was present. Future studies are needed to confirm these findings prospectively, and to develop preventive strategies for populations at risk.

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“…It might be absent during periods of mania (Fogarty et al 1994 ). Bulimia nervosa (BN) is seen in 1.4-7.5 % of BD patients (Baldassano et al 2005 ;McElroy et al 2001McElroy et al , 2011Pini et al 1999 ;Strakowski et al 1992Strakowski et al , 1993Vieta et al 2001 ;Seixas et al 2012 ;Fornaro et al 2010 ) and up to 7-12 % in bipolar females (Baldassano et al 2005 ;Strakowski et al 1992 ;Schuckit et al 1996 ). Reversely, BN patients are at a 4.5 times higher risk to also suffer from BD (Lunde et al 2009 ).…”

Section: Comorbid Eating Disordersmentioning

confidence: 96%

Comorbidity

Fountoulakis¹

2014

Bipolar Disorder

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Gender differences in bipolar disorder: retrospective data from the first 500 STEP‐BD participants

Cited by 129 publications

References 19 publications

Comorbid Anxiety in Bipolar Disorder Alters Treatment and Prognosis

Comorbid Anxiety in Bipolar Disorder Alters Treatment and Prognosis

Prevalence and correlates of bipolar I disorder among adults with primary youth‐onset anxiety disorders

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