Gender Differences in Cardiac Chronotropic Control: Implications for Heart Rate Variability Research

Williams, DeWayne P.; Joseph, Nicholas; Gerardo, Gina M.; Hill, LaBarron K.; Koenig, Julian; Thayer, Julian F.

doi:10.1007/s10484-021-09528-w

Cited by 22 publications

(42 citation statements)

References 24 publications

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“…Our second hypothesis that relations between HRV and COVID-19-associated worries would be more pronounced in women compared to men was supported, emphasizing the previously suggested importance of considering sex with respect to both HRV ( Williams et al, 2022 ) and worry tendency ( Robichaud et al, 2003 ).…”

Section: Discussionsupporting

confidence: 54%

High-frequency variability in heart rate is related to COVID-19-associated worries six years later

Wekenborg

Schwerdtfeger

Aust

et al. 2022

Biological Psychology

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Section: Discussionsupporting

confidence: 54%

High-frequency variability in heart rate is related to COVID-19-associated worries six years later

Wekenborg

Schwerdtfeger

Aust

et al. 2022

Biological Psychology

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“…Yet, higher psychopathology (i.e., depression and anxiety) is associated with greater substance issues (36,37), and thus, ER difficulties may be particularly linked with a history of drug use in women. Relatedly, studies have shown that the negative association between resting HRV and both self-reported ER difficulties (27) and HR (38) is stronger in women than men; these data suggest basic psychophysiological differences between women and men which might extend to drug use tendencies.…”

Section: Gender Differencesmentioning

confidence: 89%

Resting Heart Rate Variability, Perceived Emotion Regulation, and Low-Risk Drug Use in College-Aged Adults: Gender as a Moderator

et al. 2022

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Identification of individual differences in drug use is warranted, as a history of use is associated with future drug problems. Such drug use is thought to disrupt inhibitory and motivation networks involved in emotion regulation (ER). Higher resting heart rate variability (HRV), a biomarker of effective inhibitory abilities, is associated with less substance (e.g., alcohol, opioid) use. Higher HRV is associated with lower perceived ER difficulties, and this link is stronger in women relative to men. Evidence suggests women might engage in drug use primarily to reduce stress, and men primarily to induce feelings of elation. Research has yet to examine associations among individuals’ difficulties in ER, resting HRV, and a recent history of drug use; the current study explored this, in addition to how these associations might differ as a function of gender. Young and healthy college students (N = 190; 88 women) completed a 5-min baseline to assess resting HRV, followed by the 36-item difficulties in ER Scale and 10-item Drug Abuse Screening Test. Higher difficulties in ER, but not resting HRV, were associated with a greater history of “low-risk” drug use in the full sample and moderation tests confirm this link was stronger in women. Moderated-mediation results confirmed an indirect association between resting HRV and drug use, mediated by self-reported difficulties among women only. A significant association between resting HRV and Difficulties in Emotion Regulation Scale (DERS) emerged only among women without a history of drug use. These results indicate that difficulties in ER are both associated with a low-risk history of drug use and underlie an indirect link between resting HRV and drug use history in women only. Among these women with a history of drug use relative to women without, there was no link between resting HRV and self-reported difficulties in ER, suggesting a disrupted inhibitory-motivational pathway. Additional work is needed to understand the psychophysiological correlates of a history of low-risk drug use in young men. These data are in line with research suggesting gender differences in the motivation to engage in recreational drug use and ER interventions might be important in women who engage in low-risk recreational drug use.

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“…This study possessed the limitations of being performed at a single institution and in a small patient population. In addition, the gender imbalance of participants may affect the results [ 32 ]. The difference in exercise parameters between the three groups is another limitation of this retrospective data.…”

Section: Discussionmentioning

confidence: 99%

The Autonomic Imbalance of Myocardial Ischemia during Exercise Stress Testing: Insight from Short-Term Heart Rate Variability Analysis

Lin

Tsai

Chang³

et al. 2022

IJERPH

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Exercise stress testing (EST) has limited power in diagnosing obstructive coronary artery disease (CAD). The heart rate variability (HRV) analysis might increase the sensitivity of CAD detection. This study aimed to evaluate the correlation between short-term HRV and myocardial ischemia during EST, including the acceleration, maximum, and recovery stages of heart rate (HR). The HRV during EST from 19 healthy (RHC) subjects and 35 patients with CAD (25 patients with insignificant CAD (iCAD), and 10 patients with significant CAD (sCAD)) were compared. As a result, all HRV indices decreased at the maximum stage and no significant differences between iCAD and sCAD were found. The low-frequency power of heart rate signal (LF) of the RHC group recovered relatively quickly from the third to the sixth minutes after maximum HR, compared with that of the sCAD group. The relative changes of most HRV indices between maximum HR and recovery stage were lower in the sCAD group than in the RHC group, especially in LF, the standard deviation of all normal to normal intervals (SDNN), and the standard deviation in the long axis direction of the Poincaré plot analysis (SD2) indices (p < 0.05). The recovery slope of LF was significantly smaller in the sCAD group than in the RHC group (p = 0.02). The result suggests that monitoring short-term HRV during EST provides helpful insight into the cardiovascular autonomic imbalance in patients with significant CAD. The relative change of autonomic tone, especially the delayed sympathetic recovery, could be an additional marker for diagnosing myocardial ischemia.

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Gender Differences in Cardiac Chronotropic Control: Implications for Heart Rate Variability Research

Cited by 22 publications

References 24 publications

High-frequency variability in heart rate is related to COVID-19-associated worries six years later

High-frequency variability in heart rate is related to COVID-19-associated worries six years later

Resting Heart Rate Variability, Perceived Emotion Regulation, and Low-Risk Drug Use in College-Aged Adults: Gender as a Moderator

The Autonomic Imbalance of Myocardial Ischemia during Exercise Stress Testing: Insight from Short-Term Heart Rate Variability Analysis

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