Gender differences in clinical, immunological, and virological outcomes in highly active antiretroviral-treated HIV&amp;ndash;HCV coinfected patients

Emery, Joel; Pick, Neora; Mills, Edward J.; Cooper, Curtis

doi:10.2147/ppa.s9949

Cited by 8 publications

(2 citation statements)

References 34 publications

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“…40 However, in concordance with previous studies, we reported that virological and immunological outcomes did not differ by gender. 9,11 Several limitations of our study need to be considered. We used serological rather than molecular tests for the multivariate analysis because of the relatively low numbers of patients in the study with positive RNA HCV tests.…”

Section: Transactions Of the Royal Society Of Tropical Medicine And H...mentioning

confidence: 98%

“…12 Since this measure influences the timing of HAART initiation, it is plausible that women might start treatment later than men, which could contribute to poorer outcomes in female patients compared to male patients. 9,12 HAART is comprised of complex drug regimens, which require strict adherence to complicated dosing schedules to ensure optimal long-term clinical and survival benefits. At least 95% adherence is required for an adequate virological and immunological response.…”

Section: Introductionmentioning

confidence: 99%

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Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection

Farías

Kremer²,

Allende³

et al. 2013

Transactions of the Royal Society of Tropical Medicine and Hygi

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Section: Transactions Of the Royal Society Of Tropical Medicine And H...mentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection

Farías

Kremer²,

Allende³

et al. 2013

Transactions of the Royal Society of Tropical Medicine and Hygi

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The relevance of Tim-3 polymorphisms and F protein to the outcomes of HCV infection

Pei

Jiang

et al. 2016

Eur J Clin Microbiol Infect Dis

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Hepatitis C virus (HCV) is one of the major causes of liver inflammation. The aim of this study was to investigate the associations of T-cell immunoglobulin and mucin domain-3 (Tim-3) polymorphisms and the alternate reading frame protein (F protein) with the outcomes of HCV infection. Three single-nucleotide polymorphisms (SNPs; rs10053538, rs12186731, and rs13170556) of Tim-3 were genotyped in this study, which included 203 healthy controls, 558 hepatitis C anti-F-positive patients, and 163 hepatitis C anti-F-negative patients. The results revealed that the rs12186731 CT and rs13170556 TC and CC genotypes were significantly less frequent in the anti-F-positive patients [odds ratio (OR) = 0.54, 95 % confidence interval (CI) = 0.35-0.83, p = 0.005; OR = 0.26, 95 % CI = 0.18-0.39, p < 0.001; and OR = 0.19, 95 % CI = 0.10-0.35, p < 0.001, respectively), and the rs13170556 TC genotype was more frequent in the chronic HCV (CHC) patients (OR = 1.70, 95 % CI = 1.20-2.40, p = 0.002). The combined analysis of the rs12186731 CT and rs13170556 TC/CC genotypes revealed a locus-dosage protective effect in the anti-F-positive patients (OR = 0.22, 95 % CI = 0.14-0.33, p trend < 0.001). Stratified analyses revealed that the frequencies of the rs12186731 (CT + TT) genotypes were significantly lower in the older (OR = 0.31, 95 % CI = 0.15-0.65, p = 0.002) and female (OR = 0.30, 95 % CI = 0.17-0.52, p < 0.001) subgroups, and rs13170556 (TC + CC) genotypes exhibited the same effect in all subgroups (all p < 0.001) in the anti-F antibody generations. Moreover, the rs13170556 (TC + CC) genotypes were significantly more frequent in the younger (OR = 1.86, 95 % CI = 1.18-2.94, p = 0.007) and female (OR = 2.38, 95 % CI = 1.48-3.83, p < 0.001) subgroups of CHC patients. These findings suggest that the rs12186731 CT and rs13170556 TC/CC genotypes of Tim-3 provide potential protective effects with the F protein in the outcomes of HCV infection and that these effects are related to sex and age.

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Disengagement from Care Among People Co-Infected with HIV and HCV: A Scoping Review

Dinh,

Tan,

Saeed

2024

AIDS Behav

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Gender differences in clinical, immunological, and virological outcomes in highly active antiretroviral-treated HIV–HCV coinfected patients

Cited by 8 publications

References 34 publications

Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection

Determinants of immunological and virological responses to antiretroviral therapy amongst HIV-infected adults in central Argentina: negative influence of hepatitis C infection

The relevance of Tim-3 polymorphisms and F protein to the outcomes of HCV infection

Disengagement from Care Among People Co-Infected with HIV and HCV: A Scoping Review

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