Gender differences in cue exposure reactivity and 9-month outcome

Sterling, Robert C.; Dean, Jessica; Weinstein, Stephen P.; Murphy, J. G.; Gottheil, Edward

doi:10.1016/j.jsat.2004.03.008

Cited by 77 publications

(18 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous findings have been relatively equivocal, with regard to gender differences in drug-cue reactivity (see Introduction). However, one study using scripted vignettes comprising personal cocaine-related stimuli indicated that males were significantly more cue-reactive than females, both in relation to objective (skin conductance) and subjective (craving) arousal (Sterling et al 2004). While there were no significant gender differences in cortisol response in the current study, males were shown to be more reactive to the drug cue, compared with stress condition, and this was not seen in females.…”

Section: Discussioncontrasting

confidence: 81%

See 1 more Smart Citation

Gender differences in cardiovascular and corticoadrenal response to stress and drug cues in cocaine dependent individuals

et al. 2006

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 81%

“…Findings have shown women to be more cue-reactive than men (Elman et al 2001) and vice versa (Sterling et al 2004), while other studies have shown no gender variations in subjective or physiological responses to cues (Avants et al 1995;Robbins et al 1999).…”

Section: Introductionmentioning

confidence: 91%

Gender differences in cardiovascular and corticoadrenal response to stress and drug cues in cocaine dependent individuals

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Our findings that men were more reactive to the cue condition than females are consistent with some previous research. Sterling et al (2004) showed that males were significantly more physiologically reactive to cocaine-related cues and triggers than females, while other studies have shown no gender variation (Robbins et al, 1999;Avants et al, 1995). In this study, increased cue reactivity in males (and more specifically cocaine-abusing males) was a robust finding and is supported by neuroimaging research where males showed greater cue-induced activation of paralimbic regions associated with automatic emotional processing (Li et al, 2005).…”

Section: Discussionsupporting

confidence: 77%

Enhanced Emotional and Physiological Sensitivity to Stress and Drug/Alcohol Craving in Abstinent Cocaine-Dependent Individuals Compared to Socially Drinking Controls

Fox

Hong

Siedlarz

et al. 2007

Neuropsychopharmacology

View full text Add to dashboard Cite

Chronic exposure to cocaine is associated with neuroadaptions in stress and reward circuits that may increase susceptibility to relapse. We examined whether there are alterations in stress response and craving in abstinent cocaine-dependent individuals compared with a demographically matched group of non-addicted socially drinking community controls. Forty treatment-engaged abstinent cocaine patients (17F/23M) and 40 controls (19F/21M) were exposed to a brief 5 min guided imagery of individually calibrated stressful situations, personal drug/alcohol-related situation and a neutral-relaxing situation, one imagery per session, presented in random order. Craving, anxiety, emotion rating scales, and physiological measures were assessed. Cocaine patients reported significantly higher and more persistent stress-and cue-induced drug/alcohol craving, negative emotions, and physiological responses compared with social drinkers. In cocaine patients, stress-and cue-induced drug craving was accompanied by increased anger, fear, sadness, heart rate, and SBP. Controls reported minimal stress-induced craving and only increases in anxiety and SBP during stress exposure. Cue-induced alcohol craving was accompanied only by an increase in relaxed state. Females reported increased stress-induced anxiety and sadness compared with males, while males were emotionally and physiologically more reactive in the cue condition. These findings are the first to document functional alterations in stress-and reward-related affect and physiology in recently abstinent cocaine patients that is marked by an enhanced sensitivity to stress-and drug-related cue exposure. These data suggest that recovery from chronic cocaine abuse could be hampered by a hyper-responsive stress-and drug-craving state that increases cocaine relapse susceptibility.

show abstract

“…During cocaine withdrawal, the spontaneous, stressor cue-associated cocaine craving correlates with anxiety, anger, fear, and sadness [9,10], that are predictive of relapse [11]. In different studies, women were found to be more [12,13], less [14] or similarly reactive [15] to drug-associated cues during cocaine withdrawal, when compared to males. A contribution of these potential differences to sexual dimorphism in cocaine addiction remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Gender differences in zebrafish responses to cocaine withdrawal

López‐Patiño

Yamamoto

et al. 2008

Physiology & Behavior

View full text Add to dashboard Cite

The acute responses to cocaine and its withdrawal contribute to cocaine dependence and potentiate relapse, with gender being one of the genetic factors affecting the outcome. Here we report that in both male and female zebrafish (Danio rerio, AB strain), an initial low-dose cocaine treatment (1.5μM, immersion) does not acutely change their behavior. The cocaine withdrawal, however, is associated with an anxiety-like state that develops earlier in female zebrafish but is more robust and persistent in males, and can be acutely attenuated by cocaine administration. This is not a result of gender differences in the expression of anxiety-like state, since behavioral responses to an anxiogenic drug, FG-7142, are similar in male and female zebrafish. The basal brain dopamine (DA) levels and the expression of dopamine transporter mRNA (zDAT) show no significant sexual dimorphism. Acute cocaine exposure does not significantly change DA or zDAT. Withdrawal from repeated cocaine administration results in an overall reduction in zDAT, as well as an increase in DA levels. Neither treatment leads to significant gender differences in brain DA or zDAT. The common and gender-specific effects of cocaine on zebrafish, a well-characterized model of vertebrate development and genetics, should help in understanding the mechanisms involved in the anxiety associated with cocaine withdrawal and provide new opportunities in search for therapeutic solutions.

show abstract

Gender differences in cue exposure reactivity and 9-month outcome

Cited by 77 publications

References 20 publications

Gender differences in cardiovascular and corticoadrenal response to stress and drug cues in cocaine dependent individuals

Gender differences in cardiovascular and corticoadrenal response to stress and drug cues in cocaine dependent individuals

Enhanced Emotional and Physiological Sensitivity to Stress and Drug/Alcohol Craving in Abstinent Cocaine-Dependent Individuals Compared to Socially Drinking Controls

Gender differences in zebrafish responses to cocaine withdrawal

Contact Info

Product

Resources

About