Gender-differences in disease distribution and outcome in hospitalized elderly: Data from the REPOSI study

Corrao, Salvatore; Santalucia, Paola; Argano, Christiano; Djade, Codjo Djignefa; Barone, Eugenio; Tettamanti, Mauro; Pasina, Luca; Franchi, Carlotta; Eldin, Tarek Kamal; Marengoni, Alessandra; Salerno, Francesco; Marcucci, Maura; Mannucci, Pier Mannuccio; Nobili, Alessandro

doi:10.1016/j.ejim.2014.06.027

Cited by 80 publications

(66 citation statements)

References 45 publications

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“…Corrao et al (17) found a prevalence of chronic disease in 55%-98% of people aged >65 years, and 97.9% of the elderly had chronic diseases. The current study revealed that chronic diseases were observed more often in low-and middle-income countries (2), and the elderly living in rural areas were more prone to developing chronic diseases (18).…”

Section: Discussionmentioning

confidence: 99%

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The Prevalence of Chronic Diseases and Drug Use Among Geriatric Cases in Ardesen County of Rize Province

Sarımehmet¹,

Hintistan²

2017

Bezmialem Science

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ÖZAmaç: Bu çalışmanın amacı, Rize ili Ardeşen ilçesindeki geriatrik olgular arasında kronik hastalık sıklığı ve ilaç kullanımlarını değerlendirmektir. Yöntemler: Kesitsel ve tanımlayıcı ilişki arayıcı nitelikteki çalış-ma, Mart-Haziran 2014 tarihleri arasında 482 yaşlı bireyle yapıl-dı. Veriler, yüz yüze görüşme tekniği tekniği kullanılarak Kişisel Bilgi Formu ile toplandı. Veriler, yüzdelik ve Ki kare testi ile değerlendirildi. Bulgular: Bu çalışmada, yaşlıların %52,9'u 65-74 yaş grubunda ve %97,9'u kronik hastalığa sahiptir. Yaşlıların en sık karşılaş-tığı kronik hastalık, kardiyovasküler sisteme ait hastalıklardır (%74,3). Yaşlıların %49'u günde 3-4 adet ilaç kullanmakta ve %99,2'si bu ilaçları oral yoldan almaktadır. Ancak kullanılan bu ilaçlar, yaşlıların %24,3'ünde gastrointestinal yakınmalara neden olmaktadır. Yaşlıların %44,6'sının ilaç kullanımları ile ilgili en zorlayıcı durumu ilaç almayı unutmaktır. Yaşlıların kronik hastalık süresini cinsiyet, yaş, meslek, aylık gelir düzeyi ve sosyal gü-vence etkilerken; günlük kullandıkları ilaç sayısını yaş, medeni durum, eğitim düzeyi, meslek, sosyal güvence ve birlikte yaşanı-lan kişiler etkilemektedir (p<0,05). Sonuç: Kronik hastalık gelişimi ve bu hastalıkların tedavisinde kullanılan ilaçlarla ilgili risk faktörlerini azaltmaya yönelik önle-yici tedbirlere odaklanılmalıdır. Anahtar Kelimeler: Kronik hastalık, ilaç kullanımı, yaşlı, sıklık ABSTRACTObjective: This study aimed to evaluate the prevalence of chronic diseases and drug use among geriatric cases in Ardesen County of Rize Province. Methods: A cross-sectional and descriptive correlational study including 482 elderly was conducted between March and June 2014. Data were collected using the personal information form via faceto-face interviews. All data were analyzed as percentages using the chi-square test. Results: In this study, 97.9% of the elderly had chronic diseases and 52.9% were in the 65-74-year age group. The most frequent chronic diseases included those of the cardiovascular system (74.3%). In addition, 49% of the group used three or four medications daily, and 99.2% took their medications orally. However, these medications caused gastrointestinal problems for 24.3% of the subjects. For 44.6% of the elderly, the most challenging aspect regarding their medications was forgetting to take them. Sex, age, profession, monthly income level, and social security status affected the duration of the chronic diseases of the elderly, whereas age, marital status, educational level, profession, social security coverage, and the people with whom they lived affected the number of medications used daily by this group (p<0.05). Conclusion: Preventive measures should focus on reducing risk factors related to the development of chronic diseases and the drugs used to treat them.

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Section: Discussionmentioning

confidence: 99%

“…Corrao et al (17) reported that women live longer and outnumber men. In contrast, older women develop more chronic diseases, and being female, older, and having a low socioeconomic level are associated with multimorbidity and an increased risk for hospitalization.…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Chronic Diseases and Drug Use Among Geriatric Cases in Ardesen County of Rize Province

Sarımehmet¹,

Hintistan²

2017

Bezmialem Science

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“…Data from the REPOSI registry indicate a prevalence of heart failure close to 30% in COPD patients aged >65 years with comorbidities [3].…”

Section: Copd and Cardiovascular Comorbiditiesmentioning

confidence: 99%

“…It results in a substantial waste of economic resources, in particular from dealing with exacerbations and hospitalisations [2,3]. COPD is becoming more widespread in both industrialised and developing countries, with its prevalence reaching ∼5% in Western countries.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness and safety of concurrent beta-blockers and inhaled bronchodilators in COPD with cardiovascular comorbidities

Corrao

Brunori²,

Lupo³

et al. 2017

Eur Respir Rev

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Chronic obstructive pulmonary disease (COPD) is the most common chronic respiratory disease and its prevalence is increasing worldwide, in both industrialised and developing countries. Its prevalence is ∼5% in the general population and it is the fourth leading cause of death worldwide. COPD is strongly associated with cardiovascular diseases; in fact, ∼64% of people suffering from COPD are treated for a concomitant cardiovascular disease and approximately one in three COPD patients die as a consequence of cardiovascular diseases.Inhaled bronchodilators might have adverse cardiovascular effects, including ischaemic events and arrhythmias, and beta-blockers might adversely influence the respiratory symptoms and the response to bronchodilators. For these reasons, it is important to know the safety profiles and the possible interactions between these two classes of drug, in order to prescribe them with greater awareness.In this article, we review the literature about the epidemiology of COPD, its association with cardiovascular diseases, and the safety of concurrent use of inhaled bronchodilators and beta-blockers, as a tool for improving the approach to complex therapies in clinical practice.

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Hyperglycemia at admission, comorbidities, and in-hospital mortality in elderly patients hospitalized in internal medicine wards: data from the RePoSI Registry

Corrao

Nobili

Natoli³

et al. 2021

Acta Diabetol

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Aims The association between hyperglycemia at hospital admission and relevant short- and long-term outcomes in elderly population is known. We assessed the effects on mortality of hyperglycemia, disability, and multimorbidity at admission in internal medicine ward in patients aged ≥ 65 years. Methods Data were collected from an active register of 102 internal medicine and geriatric wards in Italy (RePoSi project). Patients were recruited during four index weeks of a year. Socio-demographic data, reason for hospitalization, diagnoses, treatment, severity and comorbidity indexes (Cumulative Illness rating Scale CIRS-SI and CIRS-CI), renal function, functional (Barthel Index), and cognitive status (Short Blessed Test) and mood disorders (Geriatric Depression Scale) were recorded. Mortality rates were assessed in hospital 3 and 12 months after discharge. Results Of the 4714 elderly patients hospitalized, 361 had a glycemia level ≥ 250 mg/dL at admission. Compared to subjects with lower glycemia level, patients with glycemia ≥ 250 mg/dL showed higher rates of male sex, smoke and class III obesity. These patients had a significantly lower Barthel Index (p = 0.0249), higher CIRS-SI and CIRS-CI scores (p = 0.0025 and p = 0.0013, respectively), and took more drugs. In-hospital mortality rate was 9.2% and 5.1% in subjects with glycemia ≥ 250 and < 250 mg/dL, respectively (p = 0.0010). Regression analysis showed a strong association between in-hospital death and glycemia ≥ 250 mg/dL (OR 2.07; [95% CI 1.34–3.19]), Barthel Index ≤ 40 (3.28[2.44–4.42]), CIRS-SI (1.87[1.27–2.77]), and male sex (1.54[1.16–2.03]). Conclusions The stronger predictors of in-hospital mortality for older patients admitted in general wards were glycemia level ≥ 250 mg/dL, Barthel Index ≤ 40, CIRS-SI, and male sex.

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Gender-differences in disease distribution and outcome in hospitalized elderly: Data from the REPOSI study

Abstract: Our study showed a gender dimorphism in the demographic and morbidity profiles of hospitalized elderly people, emphasizing once more the need for a personalized process of healthcare.

Cited by 80 publications

References 45 publications

The Prevalence of Chronic Diseases and Drug Use Among Geriatric Cases in Ardesen County of Rize Province

The Prevalence of Chronic Diseases and Drug Use Among Geriatric Cases in Ardesen County of Rize Province

Effectiveness and safety of concurrent beta-blockers and inhaled bronchodilators in COPD with cardiovascular comorbidities

Hyperglycemia at admission, comorbidities, and in-hospital mortality in elderly patients hospitalized in internal medicine wards: data from the RePoSI Registry

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