Background
Gaps in the literature exist regarding health-related quality of life (HRQOL) early after left ventricular assist device (LVAD) surgery. The purposes of our study were to describe HRQOL over time, by age and gender, and identify risk factors for poor HRQOL early after LVAD implant.
Methods
Patients (n=7,353) from INTERMACS received a continuous flow LVAD as a primary implant at 133 U.S. hospitals. Of these, 5,640 patients had pre LVAD HRQOL data, and 3,353 patients had 6 month post LVAD HRQOL data. There were 2,748 patients with data at both time periods. HRQOL was measured using the EQ-5D-3L instrument. Data were collected pre-implant and 3 and 6 months post-operatively. Statistical analyses included chi square, t-tests, Pearson correlation coefficients, and multiple regression.
Results
Overall HRQOL and dimensions of HRQOL improved from before to 6 months after device implant when examined by age and gender. However, younger patients and women reported significantly more problems regarding all dimensions before implant and significantly more problems regarding pain/discomfort and anxiety/depression at both 3 and 6 months after implant. An increase in overall HRQOL from before to 6 months after implant was related to pre implant INTERMACS level 1. Factors related to a decrease in HRQOL from before to 6 months after implant were listed for heart transplant before surgery, co-morbidities, better preoperative HRQOL, adverse events within 6 months after implant, and bridge to transplant moderately likely and unlikely, and NYHA class 4 at 6 months post LVAD (R2=41%).
Conclusions
Overall HRQOL and dimensions of HRQOL improve in subgroups of patients from before to 6 months after surgery, although differences in improvement exist. Adverse events are risk factors for decreased HRQOL across time and support the ongoing need to improve device technology with the aim of reducing adverse events.