2017
DOI: 10.1016/j.jjcc.2016.02.022
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Gender differences in management and clinical outcomes of atrial fibrillation patients

Abstract: There are significant gender differences in baseline demographics and clinical outcomes of AF patients. Women have higher mortality and ischemic strokes and are less often prescribed anticoagulation therapy despite higher CHADS scores. These data have important clinical implications.

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Cited by 39 publications
(33 citation statements)
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“…Moreover, our results showed that the female participants were older than the male participants (mean age: 75.7 vs. 71.2 years, data not shown) and a higher proportion of these were over 65 years old (85.5% vs. 74.9%, data not shown). Kassim et al [30] also reported similar results (mean age: 72.5 vs. 66.8 years). In the present study, it appears that female sex was identified as a risk factor in univariate analysis owing to the age differences between the female and male participants.…”
Section: Discussionsupporting
confidence: 52%
“…Moreover, our results showed that the female participants were older than the male participants (mean age: 75.7 vs. 71.2 years, data not shown) and a higher proportion of these were over 65 years old (85.5% vs. 74.9%, data not shown). Kassim et al [30] also reported similar results (mean age: 72.5 vs. 66.8 years). In the present study, it appears that female sex was identified as a risk factor in univariate analysis owing to the age differences between the female and male participants.…”
Section: Discussionsupporting
confidence: 52%
“…They were more likely to be treated with an “ablate and pace” strategy, i.e. AV node ablation and pacemaker implantation [ 11 ].…”
Section: Management: Rate Control and Rhythm Controlmentioning
confidence: 99%
“…Kassim et al, in their cohort study of close to 6000 patients, showed a significant difference in the anticoagulation of women and men, 76.8% and 82.5%, respectively. This was driven by a difference in anticoagulation between women and men over the age of 75 years, perhaps due to a perception of increased bleeding in older women [ 11 ]. The South Korean CODE-AF registry showed no significant difference in the prescription of anticoagulation between women and men, though women prescribed DOACs were more likely to be insufficiently dosed [ 29 ].…”
Section: Management: Stroke Risk Reductionmentioning
confidence: 99%
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“…In summary, studies have examined and compared the stroke risk between sexes in patients with AF and have found that women had a comparable 23 24 or higher risk25 26 compared with men. The conventional CHA 2 DS 2 -VASc score thus has limitations to appropriately guide the stroke risk evaluation in female patients with AF.…”
Section: Discussionmentioning
confidence: 99%