Gender differences in pancreatic neuroendocrine neoplasms: A retrospective study based on the population of Hubei Province, China

Fu, Mengfei; Yu, Li; Yang, Liu; Chen, Yang; Chen, Xiao; Hu, Qinyu; Sun, Hui

doi:10.3389/fendo.2022.885895

Cited by 6 publications

(2 citation statements)

References 46 publications

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“…Although SPTP possesses distinct features, it has similarities and overlaps with other tumors, such as non-functional PNET[ 67 ] and acinar cell carcinoma[ 37 ]. A comprehensive differential diagnosis of SPTP is presented in Table 3 [ 68 - 72 ].…”

Section: Diagnosismentioning

confidence: 99%

Unraveling the enigma: A comprehensive review of solid pseudopapillary tumor of the pancreas

Xu,

Fu,

Yang

2024

World J Gastrointest Oncol

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Solid pseudopapillary tumor of the pancreas (SPTP) is a rare neoplasm predominantly observed in young females. Pathologically, CTNNB1 mutations, β-catenin nuclear accumulation, and subsequent Wnt-signaling pathway activation are the leading molecular features. Accurate preoperative diagnosis often relies on imaging techniques and endoscopic biopsies. Surgical resection remains the mainstay treatment. Risk models, such as the Fudan Prognostic Index, show promise as predictive tools for assessing the prognosis of SPTP. Establishing three types of metachronous liver metastasis can be beneficial in tailoring individualized treatment and follow-up strategies. Despite advancements, challenges persist in understanding its etiology, establishing standardized treatments for unresectable or metastatic diseases, and developing a widely recognized grading system. This comprehensive review aims to elucidate the enigma by consolidating current knowledge on the epidemiology, clinical presentation, pathology, molecular characteristics, diagnostic methods, treatment options, and prognostic factors.

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Section: Diagnosismentioning

confidence: 99%

Unraveling the enigma: A comprehensive review of solid pseudopapillary tumor of the pancreas

Xu,

Fu,

Yang

2024

World J Gastrointest Oncol

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“…Literature on gender differences in this field is very limited, and available data are at least partially inconsistent [ 4 , 10 – 12 ]. As in other tumors, gender might be relevant in influencing the clinical characteristics presentation and prognosis of NEN-related CaS, providing an intriguing tool to obtain more effective and safe therapeutic strategies, tailored on patient’s characteristics.…”

Section: Introductionmentioning

confidence: 99%

Gender-related differences in patients with carcinoid syndrome: new insights from an Italian multicenter cohort study

Ruggeri,

Altieri,

Razzore

et al. 2023

J Endocrinol Invest

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Background The incidence of neuroendocrine neoplasm (NEN) and related carcinoid syndrome (CaS) has increased markedly in recent decades, and women appear to be more at risk than men. As per other tumors, gender may be relevant in influencing the clinical and prognostic characteristics of NEN-associated CS. However, specific data on carcinoid syndrome (CaS) are still lacking. Purpose To evaluate gender differences in clinical presentation and outcome of CaS. Methods Retrospective analysis of 144 CaS patients from 20 Italian high-volume centers was conducted. Clinical presentation, tumor characteristics, therapies, and outcomes (progression-free survival, PFS, overall survival, OS) were correlated to gender. Results Ninety (62.5%) CaS patients were male. There was no gender difference in the site of primary tumor, tumor grade and clinical stage, as well as in treatments. Men were more frequently smokers (37.2%) and alcohol drinkers (17.8%) than women (9.5%, p = 0.002, and 3.7%, p = 0.004, respectively). Concerning clinical presentation, women showed higher median number of symptoms (p = 0.0007), more frequent abdominal pain, tachycardia, and psychiatric disorders than men (53.3% vs 70.4%, p = 0.044; 6.7% vs 31.5%, p = 0.001; 50.9% vs. 26.7%, p = 0.003, respectively). Lymph node metastases at diagnosis were more frequent in men than in women (80% vs 64.8%; p = 0.04), but no differences in terms of PFS (p = 0.51) and OS (p = 0.64) were found between gender. Conclusions In this Italian cohort, CaS was slightly more frequent in males than females. Gender-related differences emerged in the clinical presentation of CaS, as well as gender-specific risk factors for CaS development. A gender-driven clinical management of these patients should be advisable.

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Analyses of sex-based clinicopathological differences among patients with gastrointestinal neuroendocrine neoplasms in Europe

Jann

Krieg

et al. 2023

J Cancer Res Clin Oncol

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Background Previous studies have found variations in cancer types, tumor progression, and disease outcomes between men and women. However, there is limited knowledge of the effect of sex on gastrointestinal neuroendocrine neoplasms (GI-NENs). Methods We identified 1354 patients with GI-NEN from the IQVIA’s Oncology Dynamics database. Patients were derived from four European countries (Germany, France, the United Kingdom (UK), Spain). Clinical and tumor related characteristics including patients' age, tumor stage, tumor grading and differentiation, frequency and sites of metastases, as well as co-morbidities were analyzed as a function of patients´ sex. Results Among the 1354 included patients, 626 were female and 728 were male. The median age was similar between both groups (w: 65.6 years, SD: 12.1 vs. m: 64.7 years; SD: 11.9; p = 0.452). UK was the country with the most patients, however, there was no differences in the sex ratio between the different countries. Among documented co-morbidities, asthma was more often diagnosed in women (7.7% vs. 3.7%), while COPD was more prevalent in men (12.1% vs. 5.8%). The ECOG performance states was comparable between females and males. Of note, the patients´ sex was not associated with tumor origin (e.g., pNET or siNET). Females were overrepresented among G1 tumors (22.4% vs. 16.8%), however, median proliferation rates according to Ki-67 were similar between both groups. In line, no differences in tumor stages was found and rates of metastases as well as the specific sites of metastases were similar between males and females. Finally, no differences in the applied tumor specific treatments between the both sexes became apparent. Conclusion Females were overrepresented among G1 tumors. No further sex-specific differences became apparent, highlighting that sex-related factors might play a rather subordinate role in the pathophysiology of GI-NENs. Such data may help to better understand the specific epidemiology of GI-NEN.

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Gender differences in pancreatic neuroendocrine neoplasms: A retrospective study based on the population of Hubei Province, China

Cited by 6 publications

References 46 publications

Unraveling the enigma: A comprehensive review of solid pseudopapillary tumor of the pancreas

Unraveling the enigma: A comprehensive review of solid pseudopapillary tumor of the pancreas

Gender-related differences in patients with carcinoid syndrome: new insights from an Italian multicenter cohort study

Analyses of sex-based clinicopathological differences among patients with gastrointestinal neuroendocrine neoplasms in Europe

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