This study examined gender differences in stress perception among special education students in South-East Nigerian Universities. One research question and a null hypothesis guided the study. The study design was a descriptive survey. The study sampled 800 students enrolled in special education. The instrument for collection of data was a questionnaire which measures the perception of stress in students. The research data were analyzed using mean, standard deviation and t-test. The finding of the study revealed that there was no significant between male and female academic stress. For affected students of special education to be stress-free, the collaboration of special education experts and educational stakeholders is necessary for assisting such students.