Gender differences in predictors of intensive care units admission among COVID-19 patients: The results of the SARS-RAS study of the Italian Society of Hypertension

Iaccarino, Guido; Grassı, Guıdo; Borghi, Claudio; Carugo, Stefano; Fallo, Francesco; Ferri, Claudio; Giannattasio, Cristina; Grassi, Davide; Letizia, Claudio; Mancusi, Costantino; Minuz, Pietro; Perlini, Stefano; Pucci, Giacomo; Rizzoni, Damiano; Salvetti, Massimo; Sarzani, Riccardo; Sechi, Leonardo Antonio; Veglio, Franco; Volpe, Massimo; Muiesan, María Lorenza

doi:10.1371/journal.pone.0237297

Cited by 157 publications

(205 citation statements)

References 31 publications

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“…In contrast, two other studies that respectively enrolled 416 and 1591 patients suggested that after the adjustment for confounders, hypertension was no longer an independent risk factor for COVID-19 [19,20].…”

Section: Discussionmentioning

confidence: 78%

“…The previous studies about other pneumonia demonstrated that preexisting hypertension could not independently contribute to disease progression [15,16]. Concurrently, multiple studies on COVID-19 evaluating whether the history of hypertension is a risk factor for adverse outcomes have yielded conflicting results [17][18][19][20][21][22]. Specifically, Pan et al found that hypertension has an HR of 1.80 for in-hospital mortality in 996 patients with COVID-19 [17], and Gao et al…”

Section: Discussionmentioning

confidence: 99%

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The influence of pre-existing hypertension on coronavirus disease 2019 patients

Wei

Chen

et al. 2021

Epidemiol. Infect.

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Hypertension represents one of the most common pre-existing conditions and comorbidities in Coronavirus disease 2019 (COVID-19) patients. To explore whether hypertension serves as a risk factor for disease severity, a multi-centre, retrospective study was conducted in COVID-19 patients. A total of 498 consecutively hospitalised patients with lab-confirmed COVID-19 in China were enrolled in this cohort. Using logistic regression, we assessed the association between hypertension and the likelihood of severe illness with adjustment for confounders. We observed that more than 16% of the enrolled patients exhibited pre-existing hypertension on admission. More severe COVID-19 cases occurred in individuals with hypertension than those without hypertension (21% vs. 10%, P = 0.007). Hypertension associated with the increased risk of severe illness, which was not modified by other demographic factors, such as age, sex, hospital geological location and blood pressure levels on admission. More attention and treatment should be offered to patients with underlying hypertension, who usually are older, have more comorbidities and more susceptible to cardiac complications.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

The influence of pre-existing hypertension on coronavirus disease 2019 patients

Wei

Chen

et al. 2021

Epidemiol. Infect.

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“…A review of the symptom burden of COVID‐19 highlighted that dyspnoea is the most prominent symptom, but the primary cause of death is by respiratory failure or HF or both 25 . In a large observational study, nearly three‐quarters of patients diagnosed with COVID‐19 had at least one pre‐existing condition, and over half were hypertensive 26 . In end‐stage HF patients, myocardial injury has resulted from COVID‐19, 27 but the pathophysiological mechanisms between the virus, cardiac injury, and HF are not yet understood 28 .…”

Section: Introductionmentioning

confidence: 99%

Insights into heart failure hospitalizations, management, and services during and beyond COVID‐19

et al. 2020

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Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2. The clinical presentation of this virus mainly manifests in the respiratory system but may also lead to severe complications in the cardiovascular system. The global burden of COVID-19 has led to an unprecedented need to gain further insight into patient outcomes, management, and clinical practice. This review aims to provide an overview of the current literature on heart failure (HF) hospitalizations, management, and care pathways for supporting patients during and beyond this pandemic. A literature review of five areas of interest was conducted and included: (i) HF hospitalization; (ii) recognizing the needs and supporting HF patients during COVID-19; (iii) supporting rehabilitation services; (iv) transitioning to a telehealth framework; and (v) the need for evidence. Patients with new-onset or existing HF are particularly vulnerable, but a significant reduction in HF hospital admissions has been reported. During these periods of uncertainty, the current care pathways for acute and elective cardiac patients have had to change with the relocation of HF services to protect the vulnerable and reduce transmission of COVID-19. Optimizing community HF services has the potential to reduce the pressures on secondary care during the recovery from this pandemic. Telemedicine and virtual health care are emerging technologies and overcome the risk of in-person exposure. Successful remote delivery of cardiac rehabilitation services has been reported during the pandemic. Delivery of a robust telehealth framework for HF patients will improve communication between clinician and patient. The reduction in HF admissions is a concern for the future and may result in unintended mortality. New-onset and current HF patients must understand their diagnosis and future prognosis and seek help and support using the appropriate platform when needed. Realigning HF services and the use of telemedicine and virtual health care has great potential but needs to be carefully understood to ensure engagement and approval in this population to overcome barriers and challenges.

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“…Elderly patients are less possibly to survive from a severe infection, MOF, heart and lung failure, as well as inflammatory storms leading to malignant arrhythmia, nutritional deficiencies, and electrolyte, and acid–base imbalances. Also, comorbidities greatly increase by age, including hypertension, chronic kidney disease, diabetes mellitus, chronic obstructive pulmonary disease, and thrombotic disease, which also contribute to poor survival rates in elder COVID‐19 patients 21,22 . The characteristics of severe and critical COVID‐19 patients were significantly different from the mild and moderate degree cases, which is much more sensitive to myocardial injury‐causing heart failure and deaths.…”

Section: Discussionmentioning

confidence: 99%

Myocardial injury in severe and critical coronavirus disease 2019 patients

Guo

Shen

et al. 2020

J Card Surg

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Background and Aim of the Study: To investigate the effect of myocardial injury on the prognosis of patients with severe or critical coronavirus disease 2019 (COVID-19). Methods: Between February 10, 2020 and March 31, 2020, data of severe and critical COVID-19 patients were collected and retrospectively analyzed. Admission data included age, heart rates, mean arterial pressure, and myocardial injury markers including creatine kinase isoenzyme-MB (CK-MB), myoglobin, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and interleukin-6. The endpoints included mortality, the incidence of malignant arrhythmia, and mechanical ventilation time. Univariate regression analysis, multivariate linear regression analysis, and binary logistic analysis were performed to develop the risk predictors in myocardial injury to the prognosis of severe and critical COVID-19 patients. Results: Seventy-four COVID-19 patients were included (mean age of 67.2 ± 14.6 years, male of 66.2%), including 42 severe and 32 critical cases. The mortality was 62.2%

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Gender differences in predictors of intensive care units admission among COVID-19 patients: The results of the SARS-RAS study of the Italian Society of Hypertension

Cited by 157 publications

References 31 publications

The influence of pre-existing hypertension on coronavirus disease 2019 patients

The influence of pre-existing hypertension on coronavirus disease 2019 patients

Insights into heart failure hospitalizations, management, and services during and beyond COVID‐19

Myocardial injury in severe and critical coronavirus disease 2019 patients

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