Gender Differences in Presentation, Treatment, and In-Hospital Outcome of Patients Admitted With Heart Failure Complicated by Atrial Fibrillation (from the Get With the Guidelines—Heart Failure [GWTG-HF] Registry)

Daneshvar, Mitra; Desai, Nayan; Andriulli, John; Ortman, Matthew; Eno, Eben; Hunter, Krystal; Russo, Andrea M.

doi:10.1016/j.amjcard.2017.11.014

Cited by 9 publications

(6 citation statements)

References 15 publications

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“…Gender difference is one of the factors that have not been well studied in HF due to women underrepresentation in most of the HF clinical trials [17]. The impact of gender on the outcomes of HF is still controversial, with some studies detecting a difference favoring better outcome in women and other studies failing to detect any difference [18][19][20]. Based on our results, gender failed to predict inpatient mortality.…”

Section: Discussionmentioning

confidence: 69%

Predictability of Inpatient Mortality of Different Comorbidities in Both Types of Acute Decompensated Heart Failure: Analysis of National Inpatient Sample

et al. 2021

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Background: Several prediction models have been proposed to assess the short outcomes and in-hospital mortality among patients with heart failure (HF). Several variables were used in common among those models. We sought to focus on other, yet important risk factors that can predict outcomes. We also sought to stratify patients based on ejection fraction, matching both groups with different risk factors. Methods:We conducted a retrospective cohort study utilizing the Healthcare Cost and Utilization Project National Inpatient Sample (HCUP-NIS) 2016 database.Results: There were totally 116,189 admissions for acute decompensated heart failure (ADHF). Of these, 50.9% were for heart failure with reduced ejection fraction (HFrEF) group (n = 59,195), and 49.1% were for heart failure with preserved ejection faction (HFpEF) group (n = 56,994). Overall, in-hospital mortality was 2.5% of admissions for ADHF (n = 2,869). When stratified by HF types, admissions for HFrEF had higher mortality rate (2.7%, n = 1,594) in comparison to admissions for HFpEF (2.2%, n = 1,275) (P < 0.001). Significantly associated variables in univariate analyses were age, race, hypertension, diabetes mellitus, chronic kidney disease (CKD), atrial fibrillation/flutter, obesity, and chronic ischemic heart disease (IHD), while gender and chronic obstructive pulmonary disease (COPD) did not achieve statistical significance (P > 0.1). Conclusions:To our knowledge, this is the first study to stratify HF patients based on ejection fraction and utilizing different predictors and in-hospital mortality. These and other data support the need for future research to utilize these predictors to create more accurate models in the future.

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Section: Discussionmentioning

confidence: 69%

Predictability of Inpatient Mortality of Different Comorbidities in Both Types of Acute Decompensated Heart Failure: Analysis of National Inpatient Sample

et al. 2021

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“…China has the highest current stroke incidence and mortality rates in the world 30 . In addition, the overall prevalence of AF in elderly patients with HF was lower to the rate recently reported in HF patients in elderly HF population in Western countries 31,32 . Specifically, in 246 patients with stroke, up to 158 (64.2%) patients were diagnosed with stroke but without AF, indicating that most of stroke was probably noncardioembolic.…”

Section: Discussionmentioning

confidence: 57%

A novel nomogram to predict all‐cause readmission or death risk in Chinese elderly patients with heart failure

Yang

Tao

et al. 2020

ESC Heart Failure

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Aims Elderly patients with heart failure (HF) are associated with frequent all-cause readmission or death. The present study sought to develop an accurate and easy-to-use model to predict all-cause readmission or death risk in Chinese elderly patients with HF. Methods and resultsThis was a prospective cohort study in patients with HF aged 65 or older. Demographic, comorbidity, laboratory, and medication data were collected. A Cox regression model was used to identify factors for the prediction of readmission or death at 30 days and 1 year. A nomogram was developed with bootstrap validation. Of the included 854 patients, the cumulative all-cause readmission and mortality rates were 10.5% and 11.6% at 30 days and 34.9% and 19.7% at 1 year, respectively. The independent risk factors associated with both 30 day and 1 year readmission or death were older age, stroke, diastolic blood pressure < 60 mmHg, body mass index ≤ 18.5 kg/m 2 , lower estimated glomerular filtration rate, and BNP > 400 pg/mL (all P < 0.05). Anaemia, abnormal neutrophils, and admission without angiotensin-converting enzyme inhibitors/angiotensin receptor blockers were the specific independent risk factors of 30 day all-cause readmission or death (all P < 0.05), whereas serum sodium ≤ 140 mmol/L and admission without beta-blockers were the specific independent risk factors of 1 year all-cause readmission or death (all P < 0.05). The Cindex of the 30 day and 1 year diagnosis prediction model was 0.778 [95% confidence interval (CI) 0.693-0.862] and 0.738 (95% CI 0.640-0.836), respectively. Conclusions We developed accurate and easy-to-use nomograms to predict all-cause readmission or death in Chinese elderly patients with HF. The nomograms will assist in reducing the all-cause readmission and mortality rates.

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“…La hipertensión arterial sistémica fue el principal factor de riesgo cardiometabólico en las mujeres. En cambio, la diabetes, el tabaquismo y la insuficiencia renal crónica fueron más frecuentes en hombres, resultados consistentes con los hallazgos de Daneshvar et al 9 Ogawa et al registraron una mayor frecuencia de insuficiencia cardiaca (31 %) y otras comorbilidades en la mujer con FANV en comparación con los hombres. 2 Daneshvar et al observaron diferencias entre ambos sexos respecto a la presentación clínica y factores de riesgo cardiometabólico, como la mayor edad y prevalencia de hipertensión arterial sistémica en las mujeres.…”

Section: Discussionunclassified

“…2 Daneshvar et al observaron diferencias entre ambos sexos respecto a la presentación clínica y factores de riesgo cardiometabólico, como la mayor edad y prevalencia de hipertensión arterial sistémica en las mujeres. 9 Hasta el momento no está del todo clara la causa del mayor riesgo cardioembólico en la mujer, pero se atribuye a factores proinflamatorios, disfunción endotelial y trombogenicidad. 10 El mayor deterioro de la clase funcional en la mujer observado en el presente estudio sugiere un mayor compromiso de la función ventricular izquierda, quizá relacionado con la mayor prevalencia de hipertensión arterial sistémica o la mayor edad.…”

Section: Discussionunclassified

Factores de riesgo cardiometabólico y tratamiento antitrombótico en población mexicana con fibrilación auricular e insuficiencia cardiaca con fracción de expulsión reducida

Baños-González¹,

González-Hermosillo²,

Guevara-Valtier³

et al. 2023

GMM

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Introducción: La insuficiencia cardiaca en pacientes con fibrilación auricular no valvular (FANV) es de dos a tres veces más frecuente que en individuos sin FANV. Objetivo: Identificar los factores de riesgo cardiometabólico (FRCM) y el tratamiento antitrombótico de pacientes con FANV e insuficiencia cardiaca con fracción de expulsión reducida (IC-FEr), y determinar si existen diferencias conforme al sexo. Métodos: En forma global y de acuerdo con el sexo se analizaron FRCM, riesgo protrombótico, riesgo de sangrado y terapia antitrombótica. Resultados: De 1423 pacientes con FANV, 336 tuvieron IC-FEr. Las mujeres promediaron mayor edad que los hombres. No hubo diferencia entre los sexos respecto al tipo de FANV o uso de anticoagulantes orales directos. La hipertensión arterial sistémica fue más frecuente en mujeres. Un 3.6 % de los pacientes reportó antecedente de ataque isquémico transitorio y 10 % de evento vascular cerebral, sin diferencias en cuanto al sexo. El porcentaje de hombres con riesgo embólico elevado fue mayor, pero sin tratamiento antitrombótico, en comparación con las mujeres. Conclusiones: Se encontraron diferencias significativas de acuerdo con el sexo en pacientes con FANV e IC-FEr, tanto en FRCM y algunas comorbilidades, como en el tratamiento antitrombótico de acuerdo con el riesgo embólico y de sangrado.

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Gender Differences in Presentation, Treatment, and In-Hospital Outcome of Patients Admitted With Heart Failure Complicated by Atrial Fibrillation (from the Get With the Guidelines—Heart Failure [GWTG-HF] Registry)

Cited by 9 publications

References 15 publications

Predictability of Inpatient Mortality of Different Comorbidities in Both Types of Acute Decompensated Heart Failure: Analysis of National Inpatient Sample

Predictability of Inpatient Mortality of Different Comorbidities in Both Types of Acute Decompensated Heart Failure: Analysis of National Inpatient Sample

A novel nomogram to predict all‐cause readmission or death risk in Chinese elderly patients with heart failure

Factores de riesgo cardiometabólico y tratamiento antitrombótico en población mexicana con fibrilación auricular e insuficiencia cardiaca con fracción de expulsión reducida

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