Gender differences in Singaporean Chinese patients with schizophrenia

Lee, Jimmy; Jiang, Jundong; Sim, Kang; Tay, Jenny; Subramaniam, Mythily; Chong, Siow‐Ann

doi:10.1016/j.ajp.2010.11.005

Cited by 10 publications

(7 citation statements)

References 24 publications

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“…The age of onset of prodromal events, a manifest attack and first hospitalization in men is 2 years less than in women. Our results are aligned with the data in a number of previously published studies (Abel, Drake, & Goldstein, 2010; Cocchi et al, 2014; Cohen, Gotowiec, & Seeman, 2000; Hui et al, 2014; Segarra et al, 2012; Pu et al, 2019; Eranti, MacCabe, Bundy, & Murray, 2012; Takahashi et al, 2000; Caqueo‐Urízara, Fondb, Urzúac, & Boyerb, 2018; Lee et al, 2011). However, some studies did not show differences between men and women at the age of manifest attack and first hospitalization (Choi, Chon, Kang, Jung, & Kwon, 2009; Naqvi, Murtaza, Nazir, & Naqvi, 2010).…”

Section: Discussionsupporting

confidence: 81%

“…Data suggests that men usually show onset at the age of at the age of 18‐25 years, where the second peak may be in middle age. In women, the average age is 25‐35, with the risk of developing schizophrenia after 40 years increased, as it is associated with menopause (Abel et al, 2010; Kilicaslan, Erol, Zengin, Cetinay Aydin, & Mete, 2014; Lee et al, 2011; Ochoa, Usall, Cobo, Labad, & Kulkarni, 2012; Stilo & Murray, 2010). The prodromal phase lasts an average of 4 years (Cohen et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Patients with a positive family history have an earlier age of onset due to a genetic predisposition (Esterberg, Trotman, Holtzman, Compton, & Walker, 2010; Ran et al, 2018). Men and women with a positive family history do not differ in the age of onset of the disease (Cohen et al, 2000; Esterberg et al, 2010; Lee et al, 2011; Ochoa et al, 2012). In our study, we observed an earlier onset in patients with a positive history, associated only with negative PANSS symptoms.…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that the age of onset of the disease occurs earlier in men than in women, and that the negative symptoms of schizophrenia are more pronounced (Lee et al, 2011; Tang et al, 2007). Accordingly, the structure of the disease and treatment tactics сan be different for men and women.…”

Section: Introductionmentioning

confidence: 99%

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Sex differences in social functioning of patients with schizophrenia depending on the age of onset and severity of the disease

Zorkina

Morozova

Abramova

et al. 2020

Early Intervention Psych

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Aim Schizophrenia manifests differently in women and men. This disease starts at a young age, leads to disability at working age. The aim of our work was to study sex differences, association between social factors and different parameters of the clinical picture and the course of the disease. Methods This study was performed using population of Russian patients (men: 345, women: 310). Patients were examined using DSM‐V, Bush‐Francis catatonia rating scale (BFCRS), Positive and Negative Syndrome Scale (PANSS), 4‐Items Negative Symptoms Assessment (NSA‐4) and Frontal Assessment Battery (FAB). Results Sex differences were mainly shown through negative symptoms, which were more severe in male patients. Men were shown to experience a decrease in social functioning and earlier age of onset. A positive family history further influenced negative symptoms and age of onset. When comparing scores before and after inpatient treatment (4 weeks), sex differences were not so pronounced. Female patients and patients with high levels of education, no conflictual relationship with family and active labour activity showed a later age of onset of the prodromal events and manifestation age. The decrease in the number of social contacts correlated with lower age of disability. The association between social factors and the severity of psychotic symptoms was shown across DSM‐V, PANSS, NSA‐4 and FAB, but not for BFCRS. Social factors were associated with negative symptoms of schizophrenia, but not with positive. Conclusion For successful treatment of patients with schizophrenia, the discussed factors must be considered and schizophrenia treatment methods should be primarily aimed at improving social functioning.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sex differences in social functioning of patients with schizophrenia depending on the age of onset and severity of the disease

Zorkina

Morozova

Abramova

et al. 2020

Early Intervention Psych

View full text Add to dashboard Cite

show abstract

“…Research in gender difference in schizophrenia is receiving increasing attention worldwide (Brzezinski-Sinai & Seeman, 2017;Leung & Chue, 2000;Ochoa et al, 2012). While most studies have reported that men with schizophrenia have an earlier age of onset than women (Lee et al, 2011;Tang et al, 2007), other studies have found no significant difference (Castle et al, 1998;Naqvi et al, 2005;Venkatesh et al, 2008). Some studies have also reported that men with schizophrenia have more negative symptoms, while women have more affective symptoms (Brzezinski-Sinai & Seeman, 2017;Cotton et al, 2009;Riecher-Rössler & Hãfner, 2010).…”

Section: Introductionmentioning

confidence: 99%

Gender differences in socio‐demographics, clinical characteristic and quality of life in patients with schizophrenia: A community‐based study in Shenzhen

Peng

Wang

et al. 2020

Asia-Pacific Psychiatry

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Introduction:The objective of this study was to explore the gender differences of community-dwelling patients with schizophrenia in terms of socio-demographics, clinical characteristic and quality of life (QOL).Methods: A total of 433 community-dwelling patients with schizophrenia were recruited in Shenzhen city, China. Data were obtained from a face-to-face interview with standard research questionnaire. The QOL and insight were assessed using the WHOQOL-BREF and the Chinese version of the insight and treatment attitude questionnaire, respectively.Results: This cross-sectional study included 206 male and 227 female patients. Male patients were more likely to be educated, employed, smoking cigarettes and drinking alcohol, and have an early age of illness onset. In contrast, female patients were more likely to be married/cohabitating and have drug side effects. There was no significant difference between genders across all QOL domain. Multiple regression analyzes showed that mental symptoms were negatively associated with all QOL domains, whereas frequency of exercise in the past year was positively associated with all QOL domains. Higher education levels, household per capita annual income in past year (≥100 000 RMB), employment status, IATQ score, drug side effects, marital status, and number of hospitalization were also significantly associated with specific QOL domains.Discussion: There was significant gender difference in socio-demographics and clinical characteristics among community schizophrenia patients in Shenzhen city.Gender-specific intervention measures are needed to improve the functioning and QOL in patients with schizophrenia.

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Exploration of illness perception among patients with mental illness in a multi-ethnic Asian sample

Subramaniam

Abdin

Jeyagurunathan

et al. 2018

Psychiatry Research

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Illness perceptions are beliefs that patients have about their illness. These beliefs play an important role in influencing their behaviour and outcomes. This study examined the factor structure and correlates of the Illness Perception Questionnaire Mental Health (IPQ-MH) among patients with mental illness in a multi-ethnic Asian sample. 400 participants with schizophrenia and other psychotic disorders, mood or anxiety disorder were recruited from a tertiary psychiatric institution and administered the IPQ-MH. Data on sociodemographic variables were also collected. A multi-factor structure was identified for the Identity, Structure and Cause subscale of the IPQ-MH. Age was consistently associated with a positive perception of illness across all three disorders; women had a more positive perception of schizophrenia and other psychotic disorders as compared to men while those of Indian ethnicity had a more negative perception of their mood disorder as compared to those of Chinese ethnicity. Those with lower education had a poorer understanding of their illness among those with mood disorder, and a poorer understanding of their illness and the effectiveness of treatment among those with anxiety disorder. The study identified specific groups which can be targeted through tailored and culturally relevant psychoeducational interventions to enhance their understanding and perception of mental illness.

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Gender differences in Singaporean Chinese patients with schizophrenia

Cited by 10 publications

References 24 publications

Sex differences in social functioning of patients with schizophrenia depending on the age of onset and severity of the disease

Sex differences in social functioning of patients with schizophrenia depending on the age of onset and severity of the disease

Gender differences in socio‐demographics, clinical characteristic and quality of life in patients with schizophrenia: A community‐based study in Shenzhen

Exploration of illness perception among patients with mental illness in a multi-ethnic Asian sample

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