Introduction: Obsessive-compulsive disorder (OCD) is a heterogeneous condition, in which subtypes have been proposed. Previous studies suggested that gender plays a relevant role in OCD phenotypic expression. This study aimed to review the literature on gender differences in clinical, genetic or familial aspects of OCD. Method: A conventional review was conducted, including all papers that investigated demographic, clinical, and genetic aspects of OCD according to gender. The search was based on data available in Medline and PsycINFO databases in the last 20 years, using as keywords: obsessive-compulsive disorder; and: gender, sex, male, female, demographic characteristics, clinical features, clinical characteristics, genetic, genes, genetics gender OCD, genes OCD, genes OCD males, genes OCD females. Results: Sixty three of 487 phenotypical and genetics studies were selected. Most studies indicate that male patients are more likely than females to be single, present early onset of symptoms and chronic course of the disorder, greater social impairment, more sexual-religious and aggressive symptoms, and greater comorbidity with tic and substance use disorders. Female patients present more contamination/cleaning symptoms and greater comorbidity with eating and impulse-control disorders. Genetic and family studies are inconclusive, but suggest that gender may play a role in the disease expression. Conclusions: Gender is a relevant factor that should be taken into account when evaluating OCD patients. More studies are necessary to determine whether in fact it defines a homogeneous and particular group in OCD. ©2011 Elsevier Editora Ltda. All rights reserved.
Gender differences in obsessive-
DesCRIPToRs:Obsessive-compulsive disorder; Gender identity; Sex; Phenotype; Genetics.
ReVIeW ARTICLe
391Gender differences in obsessive-compulsive disorder: a literature review
Diferenças de gĂȘnero no transtorno obsessivo-compulsivo: uma revisĂŁo da literatura ResumoIntrodução: O transtorno obsessivo-compulsivo (TOC) Ă© um quadro heterogĂȘneo, no qual subtipos tĂȘm sido propostos. Estudos anteriores sugerem que gĂȘnero desempenha papel relevante na expressĂŁo fenotĂpica. O objetivo foi realizar uma revisĂŁo convencional da literatura sobre diferenças de gĂȘnero em relação a aspectos clĂnicos e genĂ©ticos ou familiares do TOC. MĂ©todo: Realizou-se uma revisĂŁo convencional da literatura incluindo todos os artigos que investigaram aspectos sociodemogrĂĄficos, clĂnicos e genĂ©ticos do TOC, de acordo com o gĂȘnero. A pesquisa foi baseada em publicaçÔes disponĂveis nas bases de dados Medline e PsycInfo nos Ășltimos 20 anos, usando como palavras-chave: obsessive-compulsive disorder (OCD), e: gender, sex, male, female, demographic characteristics, clinical features, clinical characteristics, genetic, genes, genetics gender OCD, genes OCD, genes OCD males, genes OCD females. Resultado: Sessenta e trĂȘs artigos de fenĂłtipo e genĂ©tica foram selecionados. Na maioria dos estudos, o sexo masculino associou-se mais que o feminino com: ser solteiro, ap...