Gender differences in the association between physical activity and cognitive function in individuals with bipolar disorder

Fellendorf, Frederike T.; Kainzbauer, Nora; Platzer, Martina; Dalkner, Nina; Bengesser, Susanne; Birner, Armin; Queissner, Robert; Rauch, Philipp J.; Hamm, Carlo; Pilz, René; Reininghaus, Eva

doi:10.1016/j.jad.2017.06.048

Cited by 25 publications

(17 citation statements)

References 47 publications

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“…In addition, regular physical activity stabilizes the cytokine production and reduces the systemic proinflammatory state ( Alsuwaidan et al, 2009 ; Rosa et al, 2011 ). A better performance in cognition was shown in female individuals conducting vigorous physical activity compared to moderate or low activity ( Fellendorf et al, 2017 ). Influencing the inflammatory system beneficially by having a healthier lifestyle could therefore not only positively impact weight and MetS symptoms but also cognitive functioning.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome Impairs Executive Function in Bipolar Disorder

et al. 2021

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Background: Metabolic syndrome (MetS) is more prevalent in individuals with bipolar disorder and has a negative impact on cognition, in particular on executive function, which is already impaired in individuals with bipolar disorder compared to healthy controls.Methods: In a cross-sectional study, we compared 148 euthymic patients with bipolar disorder and 117 healthy controls in cognitive function depending on the diagnosis of MetS. A neuropsychological test battery was used including the Trail Making Test A/B, Stroop Color and Word Interference Test, the d2 Test of Attention Revised, and the California Verbal Learning Test. In addition, MetS variables as well as the defining variables waist circumference, serum triglyceride levels, high-density lipoprotein cholesterol levels, blood pressure, fasting glucose levels, and body mass index were compared between patients and controls. In addition, illness-related variables were associated with MetS in individuals with bipolar disorder.Results: The prevalence of MetS in patients with bipolar disorder was higher than in controls (30.4 vs. 15.4%). Patients with bipolar disorder with MetS had impaired executive function compared to patients without MetS or healthy controls with and without MetS (p = 0.020). No MetS effects or interaction MetS × Group was found in attention/processing speed (p = 0.883) and verbal learning/memory (p = 0.373). Clinical variables (illness duration, suicidality, number of affective episodes, medication, age of onset, and history of psychosis) did not relate to MetS in bipolar disorder (p > 0.05).Conclusion: Bipolar disorder comorbid with MetS bears additional risk for impaired executive function. Executive function includes action planning, inhibition, and impulse control and could play a critical role in keeping long-term goals in mind associated with gaining and maintaining a healthy weight.

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Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome Impairs Executive Function in Bipolar Disorder

et al. 2021

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“…Men with BD also have worse verbal memory performance (Carrus et al, ), worse recognition of happy prosody (Van Rheenen & Rossell, ), and reduced sensorimotor gating (Gogos, van den Buuse, & Rossell, ) compared to male controls; while worse recognition of surprise and fear prosody (Bozikas et al, ) and increased sensorimotor gating (Gogos et al, ) are seen in women with BD, compared with female controls. One study showed that women with BD experience greater cognitive benefit from vigorous physical activity than men with BD (Fellendorf et al, ).…”

Section: Sex Differences In Psychiatric Disordersmentioning

confidence: 99%

Sex differences in schizophrenia, bipolar disorder, and post‐traumatic stress disorder: Are gonadal hormones the link?

Gogos

Ney

Seymour

et al. 2019

British J Pharmacology

140

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In this review, we describe the sex differences in prevalence, onset, symptom profiles, and disease outcome that are evident in schizophrenia, bipolar disorder, and posttraumatic stress disorder. Women with schizophrenia tend to exhibit less disease impairment than men. By contrast, women with post-traumatic stress disorder are more affected than men. The most likely candidates to explain these sex differences are gonadal hormones. This review details the clinical evidence that oestradiol and progesterone are dysregulated in these psychiatric disorders. Notably, existing data on oestradiol, and to a lesser extent, progesterone, suggest that low levels of these hormones may increase the risk of disease development and worsen symptom severity. We argue that future studies require a more inclusive, considered analysis of gonadal steroid hormones and the intricacies of the interactions between them, with methodological rigour applied, to enhance our understanding of the roles of steroid hormones in psychiatric disorders.

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“…128 Moreover, in the first large study to analyse the association between cognition and level of physical activity in BD during euthymia, female participants in a vigorous physical activity group showed significantly better performances in most cognitive domains compared to females with moderate or low physical activity. 129 Thus, preliminary evidence suggests that physical activity/aerobic exercise confers benefits beyond an impact on physical health, including the potential to ameliorate cognitive impairments in BD.…”

Section: Lifestyle Factorsmentioning

confidence: 99%

Current understandings of the trajectory and emerging correlates of cognitive impairment in bipolar disorder: An overview of evidence

et al. 2019

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Objectives Cognitive dysfunction affects a significant proportion of people with bipolar disorder (BD), but the cause, trajectory and correlates of such dysfunction remains unclear. Increased understanding of these factors is required to progress treatment development for this symptom dimension. Methods This paper provides a critical overview of the literature concerning the trajectories and emerging correlates of cognitive functioning in BD. It is a narrative review in which we provide a qualitative synthesis of current evidence concerning clinical, molecular, neural and lifestyle correlates of cognitive impairment in BD across the lifespan (in premorbid, prodromal, early onset, post‐onset, elderly cohorts). Results There is emerging evidence of empirical links between cognitive impairment and an increased inflammatory state, brain structural abnormalities and reduced neuroprotection in BD. However, evidence regarding the progressive nature of cognitive impairment is mixed, since consensus between different cross‐sectional data is lacking and does not align to the outcomes of the limited longitudinal studies available. Increased recognition of cognitive heterogeneity in BD may help to explain some inconsistencies in the extant literature. Conclusions Large, longitudinally focussed studies of cognition and its covariation alongside biological and lifestyle factors are required to better define cognitive trajectories in BD, and eventually pave the way for the application of a precision medicine approach for individual patients in clinical practice.

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Gender differences in the association between physical activity and cognitive function in individuals with bipolar disorder

Cited by 25 publications

References 47 publications

Metabolic Syndrome Impairs Executive Function in Bipolar Disorder

Metabolic Syndrome Impairs Executive Function in Bipolar Disorder

Sex differences in schizophrenia, bipolar disorder, and post‐traumatic stress disorder: Are gonadal hormones the link?

Current understandings of the trajectory and emerging correlates of cognitive impairment in bipolar disorder: An overview of evidence

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