Gender Differences in the Correlation between Symptom and Radiographic Severity in Patients with Knee Osteoarthritis

Cho, Hyung Joon; Chang, Chong Bum; Yoo, Jae Ho; Kim, Seong-Ju; Kim, Tae Kyun

doi:10.1007/s11999-010-1282-z

Cited by 75 publications

(58 citation statements)

References 41 publications

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“…A history of knee pain, stiffness, crepitus, and swelling is common to both genders but a difference in the severity of symptoms does exist. Women typically present with worse symptoms including greater complaints of pain and disability [8,26]. More advanced radiographic findings are also common [10].…”

Section: Diagnosismentioning

confidence: 99%

Knee osteoarthritis in women

Hame

Alexander

2013

Curr Rev Musculoskelet Med

169

111

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Osteoarthritis is a disease that progresses over time and culminates in the destruction of articular cartilage and joints. Thus, with an increasing elderly population the treatment of knee osteoarthritis has become a major healthcare issue. It has been shown that women are more severely impacted by knee osteoarthritis. Differences in knee anatomy, kinematics, previous knee injury, and hormonal influences may play a role. Sex difference with respect to osteoarthritis presentation, treatment, and the allocation of resources also exists. In general, women present for treatment in more advanced stages of osteoarthritis and have more debilitating pain than their male counterparts. In addition, healthcare providers are more likely to recommend total joint arthroplasty for their male patients. Understanding how and why these gender differences occur is instrumental in formulating an inclusive strategy for combating osteoarthritis in the future.

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Section: Diagnosismentioning

confidence: 99%

Knee osteoarthritis in women

Hame

Alexander

2013

Curr Rev Musculoskelet Med

169

111

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“…More than 46 million people reported having arthritis (60.8% women), and almost 19 million people reported arthritis affected their ability to do everyday activities (63% women) [33]. Women have different gait patterns in response to osteoarthritis [12], report worse symptoms of knee osteoarthritis than men with similar radiographic severity [10], have increased rates of cartilage loss than men [19], and have greater hip degeneration [7]. Women also seek care from physicians for hip and knee problems more often than men, and this trend has persisted over the last 10 years [3].…”

Section: Why Are Sex and Gender Important In Research?mentioning

confidence: 99%

Examining Sex and Gender Disparities in Total Joint Arthroplasty

Novicoff

Saleh

2011

Clinical Orthopaedics &Amp; Related Research

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Background Total joint arthroplasty (TJA) is remarkably successful for treating osteoarthritis: most patients see substantial gains in function. However, there are considerable geographic, racial, and gender variations in the utilization of these procedures. The reasons for these differences are complex. Questions/purposes We examined sex and gender disparities in TJA. Methods Through Medline/PubMed searches, we identified 632 articles and from these selected 61 for our review. Where are we now? A number of factors might explain sex and gender disparities in TJA: underrepresentation in clinical trials, differences in willingness to undergo surgery, pain responses to underlying disease and treatment, patient-physician relationships, treatment preferences, provider-level factors such as physician-patient communication style, and system-level factors such as access to specialist care. Since women have a higher prevalence of arthritis and degenerative joint diseases and overall demand for these procedures will continue to grow, the need to understand why there is a gap in utilization based on gender is imperative. Where do we need to go? Understanding what exactly is meant by ''disparity'' is essential because it is possible anatomic factors may have different impacts on utilization from cultural factors. Ideally, information about these factors should be integrated into the decision-making process so that patients and providers can make the most informed choice about whether or not to undergo the procedure. How do we get there? To better understand all of the potential reasons for how anatomic and cultural factors related to sex and gender might impact decision-making and overall utilization of TJA, more research focusing on these factors must be designed and carried out.

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“…Weight reduction consistently resulted in decreased joint pain in patients with OA [14,15] and simultaneously decreased blood leptin levels [16][17][18]. Furthermore, leptin is particularly elevated in women and in obese patients [10,19], and in these two patient groups, higher OA pain levels have been reported [20][21][22][23][24][25][26]. Studies from outside the musculoskeletal field have lent further support to a possible association between pain and leptin concentrations.…”

Section: Introductionmentioning

confidence: 99%

Do synovial leptin levels correlate with pain in end stage arthritis?

Lübbeke

Finckh

Puskás

et al. 2013

International Orthopaedics (SICOT)

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Purpose We evaluated whether synovial fluid (SF) leptin concentrations correlate with pain severity in patients with hip or knee endstage osteoarthritis (OA) and whether they mediate the association between increased joint pain and (1) female gender and (2) obesity. Methods We conducted a cross-sectional study including patients with primary hip and knee OA undergoing joint replacement between January and December 2010. SF leptin concentrations obtained on the day of surgery were assessed. Main outcome was pain severity measured pre-operatively using WOMAC and VAS pain scales. Results A total of 219 patients were included, 123 hip and 96 knee arthroplasties. Mean age was 72 years, 59 % were women. Mean SF leptin levels were 22.9 (±25.6) ng/ml in women and 5.4 (±5.9) ng/ml in men. Levels >19.6 ng/ml (highest quartile) were significantly associated with increased pain on both WOMAC (mean difference −9.6, 95 % CI −15.1 to −4.0) and VAS scale (mean difference 0.8, 95 % CI 0.2-1.3). Associations remained unchanged after adjusting for age, co-morbidities, contra-lateral arthritic joint, OA site, and disability. The associations observed between increased pain and female gender or obesity were substantially reduced after adjusting for SF leptin. Conclusion Joint pain is associated with SF leptin concentrations. Increased pre-operative pain observed in women and obese may be related to high intra-articular leptin levels.

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Gender Differences in the Correlation between Symptom and Radiographic Severity in Patients with Knee Osteoarthritis

Cited by 75 publications

References 41 publications

Knee osteoarthritis in women

Knee osteoarthritis in women

Examining Sex and Gender Disparities in Total Joint Arthroplasty

Do synovial leptin levels correlate with pain in end stage arthritis?

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