Gender differences in the genetic and environmental determinants of adolescent depression

Uddin, Monica; Santos, Regina de los; Bakshis, Erin; Aiello, Allison E.; Galea, Sandro

doi:10.1016/j.comppsych.2010.06.046

Cited by 14 publications

(32 citation statements)

References 43 publications

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“…Second, and probably more importantly, there are gender-biased items in these scales (for instance: fear, loneliness, crying, weight loss, fatigue, dizziness, suicide ideation, irritation and appetite loss) that are known to have greater value for girls. This aspect should be carefully considered in the selection of cutoff values 29,30 .…”

Section: Discussionmentioning

confidence: 99%

Escalas psicométricas como instrumentos de rastreamento para depressão em estudantes do ensino médio

Salle¹,

Rocha²,

Rocha³

et al. 2012

Rev. psiquiatr. clín.

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Background: Depression is a major cause of suicide among adolescents. Therefore, it is crucial to find suitable depression screening tools for this population. Objective: To evaluate the use of depression rating scales as screening tools for depression in a sample of Brazilian high school students. Methods: A cross--sectional study. Three scales (BDI, CES-D, and CRS) and a screening test for general psychiatric symptoms (SRQ) were administered to a sample of 503 high school students aged between 15 to 17 years. The results were compared to those obtained with the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). Results: The prevalence of major depression using DSM-IV criteria was 10.9%. Adolescents with major depression had significantly higher (p = 0.001) scores in the SRQ and in the three scales analyzed compared to the group without depression. The sensitivity and specificity of BDI, CES-D, and CRS were 0.77 and 0.70, 0.75 and 0.73, and 0.82 and 0.71, respectively, to screen for major depression (ROC curve). The best cutoff values to suggest depression were 9 for BDI, 10 for CSR, and 14 for CES-D. The frequency of depressive symptoms was higher in girls (approximately 2:1). Discussion: The present findings support the use of the BDI, the CES-D and the CRS only for screening or as an additional symptomatic evaluation of depression in high school student. The difference in scale scores between boys and girls warns against the use of the same cutoff values for both sexes.

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Section: Discussionmentioning

confidence: 99%

Escalas psicométricas como instrumentos de rastreamento para depressão em estudantes do ensino médio

Salle¹,

Rocha²,

Rocha³

et al. 2012

Rev. psiquiatr. clín.

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“…The study of Uddin et al [181] highlights that in adolescent females, the 5-HTTLPR sl genotype confers protection against depressive symptoms independent of county-level social context, whereas in adolescent males, protection by the same genotype is conferred only within the context of county-level deprivation. Moreover, individuals carrying the 5HTTLPR short (risk) allele or BDNF Met allele had smaller hippocampal or amygdala volumes, or both, when they had a history of childhood maltreatment compared with those who had only one risk factor (environmental or genetic).…”

Section: Comorbiditiesmentioning

confidence: 99%

“…Moreover, individuals carrying the 5HTTLPR short (risk) allele or BDNF Met allele had smaller hippocampal or amygdala volumes, or both, when they had a history of childhood maltreatment compared with those who had only one risk factor (environmental or genetic). Independent of genetic risk, childhood stress predicted additional hippocampal white matter alterations [1,122,181]. (Figure 3) …”

Section: Comorbiditiesmentioning

confidence: 99%

Childhood Depression As Emerging Public Health Problem: A Systematic Review

Pimentel¹,

Júnior²,

Júnior³

et al. 2015

Int Arch Med

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As an important problem of public health, the childhood depression deserves special attention, in which the serious and long term consequences of the disease weigh to the childhood development. Taking this in consideration, the present study was based in the following research question: which practical contribution the actual scientific literature about childhood depression has to offer to clinicians and researchers? The aim of the present study was to evaluate the actual evidence concerning the different aspects (etiology/risk factors, diagnosis, treatment, prognostic and prevention) of childhood depression, with the purpose to systematize such evidences and to contribute with the knowledge about the problem. In way to reach this aim, it was performed a systematic review of articles about childhood depression, in the period from January first of 2010 to January 16 of 2014, in the databases PubMED, MEDLINE and SciELO. In the research, the following terms were used: "depression" (MeSH), "child" (MeSH) and "childhood depression" (Keyword). Of the 860 found studies, 76 met the eligibility criteria. The found studies covered a wide variety of aspects related to childhood depression, as diagnosis, treatment, prevention and prognostic. The actual scientific literature about the childhood depression converges to, directly or not, highlight the negative impacts of the depression disorders to the life quality of the children. Unfortunately, the found studies show that the childhood depression is a disorder that develops most commonly in a poverty and vulnerability scenery, where the individual and familiar necessities concerning the childhood depression are not always taken in consideration. In this context, this review demonstrates that the depression started in

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“…Further evidence, that G × E interactions between 5-HTTLPR and broader social environment could influence risk for depressive symptoms and that this effect is modified by gender, was reported by Uddin et al (2010). In males, county-level environments modified the association between 5-HTTLPR genotype and depressive symptoms across a one-year period, even when controlling for potential family-level confounders.…”

mentioning

confidence: 93%

Genotype by environment interaction and neurodevelopment III. Focus on the child's broader social ecology

Nobile

Bianchi

et al. 2013

Epidemiol Psychiatr Sci

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This Section of Epidemiology and Psychiatric Sciences regularly appears in each issue of the Journal to describe relevant studies investigating the relationship between neurobiology and psychosocial psychiatry in major psychoses. The aim of these Editorials is to provide a better understanding of the neural basis of psychopathology and clinical features of these disorders, in order to raise new perspectives in every-day clinical practice. In a short series of articles, we will review the evidence for genotype by environment interaction (G × E) in developmental psychopathology. We will focus specifically on the characteristics of types of exposure assessed with respect to both their methods and findings. This article aims to review the studies exploring the effects of the child's broader social ecology on child and adolescent internalizing and externalizing psychopathology, based on a G × E perspective.

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Gender differences in the genetic and environmental determinants of adolescent depression

Cited by 14 publications

References 43 publications

Escalas psicométricas como instrumentos de rastreamento para depressão em estudantes do ensino médio

Escalas psicométricas como instrumentos de rastreamento para depressão em estudantes do ensino médio

Childhood Depression As Emerging Public Health Problem: A Systematic Review

Genotype by environment interaction and neurodevelopment III. Focus on the child's broader social ecology

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