Gender differences in the influence of obstructive sleep apnea on optic nerve head circulation

Shiba, Tomoaki; Takahashi, Mitsuru; Matsumoto, Tadashi; Hori, Yuichi

doi:10.1038/s41598-019-55470-7

Cited by 4 publications

(3 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The MBR measured in the vessels around and at the ONH appears to reflect the entire retinal circulation 9 . In the present study, the vascular MRBs were analyzed and referred as retinal blood flow as reported by other investigators 6,8,9,36 . The MBR outcomes were expressed as percentage change from the baseline.…”

Section: Measurement Of Retinal Blood Flowmentioning

confidence: 99%

“…However, this technology was not suitable for use in animals, such as mice and rats, with small eyeballs. The laser speckle flowgraphy (LSFG) is one of the newly developed methods used for quantitative estimation of ocular (optic nerve head, choroid, and retina) blood flow in both humans 4 – 6 and animals 7 , 8 . In principle, LSFG assesses circulation in ocular tissues utilizing the laser speckle phenomenon, an interference event when coherent light sources, i.e., lasers, are scattered by a diffusing surface.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Longitudinal stability of retinal blood flow regulation in response to flicker stimulation and systemic hyperoxia in mice assessed with laser speckle flowgraphy

Hanaguri

Yokota

Watanabe

et al. 2020

Sci Rep

View full text Add to dashboard Cite

This study aimed to evaluate longitudinal changes in retinal blood flow in response to flicker stimulation and systemic hyperoxia in mice using a laser speckle flowgraphy (LSFG-Micro). The retinal blood flow in vascular area surrounding the optic nerve head was measured in 8-week-old male mice every 2 weeks until age 20-week. The coefficient of variation of retinal blood flow under resting condition was analyzed every 2 weeks to validate the consistency of the measurement. On day 1 of the experiment, retinal blood flow was assessed every 20 s for 6 min during and after 3 min flicker light (12 Hz) stimulation; on day 2, retinal blood flow was measured every minute for 20 min during and after 10 min systemic hyperoxia; and on day 3, electroretinography (ERG) was performed. Body weight, systemic blood pressure, and ocular perfusion pressure increased significantly with age, but the resting retinal blood flow and ERG parameters remained unchanged. Retinal blood flow significantly increased with flicker stimulation and decreased with systemic hyperoxia, independent of age. The LSFG-Micro provides consistent and reproducible retinal blood flow measurement in adult mice. Longitudinal assessments of retinal blood flow in response to flicker stimulation and systemic hyperoxia may be useful indexes for noninvasive monitoring of vascular function in retinas.

show abstract

Section: Measurement Of Retinal Blood Flowmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Longitudinal stability of retinal blood flow regulation in response to flicker stimulation and systemic hyperoxia in mice assessed with laser speckle flowgraphy

Hanaguri

Yokota

Watanabe

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The subject number who had a significant difference in the RI among of the age categories of 40–59 years (ACS n = 17 vs. control n = 44) might have been statistically acceptable. Second, because most of our ACS patients were male, sex differences could have had some influence on our results, as reported previously 29 . We at least indicated a descriptive result of comparing the male and female RI and BOT values between the ACS and control groups (Fig.…”

Section: Study Limitationsmentioning

confidence: 71%

Comprehensive assessment of systemic arteriosclerosis in relation to the ocular resistive index in acute coronary syndrome patients

Ebuchi

Nagaoka

Fukamachi

et al. 2022

Sci Rep

View full text Add to dashboard Cite

This study aimed to investigate the relationship between ocular vascular resistance parameters, evaluated by laser speckle flowgraphy (LSFG), and systemic atherosclerosis, renal parameters and cardiac function in acute coronary syndrome (ACS) patients. We evaluated 53 ACS patients between April 2019 and September 2020. LSFG measured the mean blur rate (MBR) and ocular blowout time (BOT) and resistivity index (RI). 110 consequent patients without a history of coronary artery disease who visited ophthalmology as a control group. Significant positive correlations were observed between ocular RI and systemic parameters in ACS patients, including intima-media thickness (r = 0.34, P = 0.015), brachial-ankle pulse-wave velocity (r = 0.41, P = 0.002), cystatin C (r = 0.32, P = 0.020), and E/e’ (r = 0.34, P = 0.013). Ocular RI was significantly higher in the ACS group than in the control group in male in their 40 s (0.37 ± 0.02 vs. 0.29 ± 0.01, P < 0.001) and 50 s (0.36 ± 0.02 vs. 0.30 ± 0.01, P = 0.01). We found that the ocular RI was associated with systemic atherosclerosis, early renal dysfunction, and diastolic cardiac dysfunction in ACS patients, suggesting that it could be a useful non-invasive comprehensive arteriosclerotic marker.

show abstract

Characteristics of laterality in the optic nerve head microcirculation obtained by laser speckle flowgraphy in healthy subjects

Kobayashi

Shiba

Okamoto

et al. 2022

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

Gender differences in the influence of obstructive sleep apnea on optic nerve head circulation

Cited by 4 publications

References 43 publications

Longitudinal stability of retinal blood flow regulation in response to flicker stimulation and systemic hyperoxia in mice assessed with laser speckle flowgraphy

Longitudinal stability of retinal blood flow regulation in response to flicker stimulation and systemic hyperoxia in mice assessed with laser speckle flowgraphy

Comprehensive assessment of systemic arteriosclerosis in relation to the ocular resistive index in acute coronary syndrome patients

Characteristics of laterality in the optic nerve head microcirculation obtained by laser speckle flowgraphy in healthy subjects

Contact Info

Product

Resources

About