Gender Differences in the Relationships among Metabolic Syndrome and Various Obesity-Related Indices with Nonalcoholic Fatty Liver Disease in a Taiwanese Population

Lin, I-Ting; Lee, Mei‐Yueh; Wang, Chih‐Wen; Wu, Deng-Chyang; Chen, Szu-Chia

doi:10.3390/ijerph18030857

Cited by 42 publications

(59 citation statements)

References 59 publications

(60 reference statements)

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“…In this context, a number of simple anthropometric indicators, biochemical indicators, and some combination of indicators, and even complex digital models have been developed to assess NAFLD risk. Among them, obesity and lipid-related indices are the most effective markers for predicting NAFLD and are widely used in epidemiological studies, including triglyceride (TG), conicity index (COI), visceral adiposity index (VAI), triglyceride-glucose (TyG) index, body roundness index (BRI), body mass index (BMI), hepatic steatosis index (HSI), waist circumference (WC), body-shape index (ABSI), waist-toheight ratio (WHtR), lipid accumulation product (LAP), triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and TyG index-related parameters (TyG-WHtR, TyG-BMI, TyG-WC) [12][13][14][15][16][17][18][19][20][21]. At present, there are very few comparative studies on the prediction of NAFLD by obesity and lipid-related indices.…”

Section: Introductionmentioning

confidence: 99%

“…At present, there are very few comparative studies on the prediction of NAFLD by obesity and lipid-related indices. The conclusions of several existing studies are controversial, and do not include TyG indexrelated parameters [21][22][23]. According to some recent studies, TyG index-related parameters are promising new indicators for predicting NAFLD [14,24].…”

Section: Introductionmentioning

confidence: 99%

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The usefulness of obesity and lipid-related indices to predict the presence of Non-alcoholic fatty liver disease

Sheng

Xie

et al. 2021

Lipids Health Dis

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Background Conicity index, body-shape index, lipid accumulation product (LAP), waist circumference (WC), triglyceride, triglyceride-glucose (TyG) index, hepatic steatosis index (HSI), waist-to-height ratio (WHtR), TyG index-related parameters (TyG-WHtR, TyG-BMI, TyG-WC), body mass index (BMI), visceral adiposity index, triglyceride to high-density lipoprotein cholesterol ratio and body roundness index have been reported as reliable markers of non-alcoholic fatty liver disease (NAFLD). However, there is debate about which of the above obesity and lipid-related indices has the best predictive performance for NAFLD risk. Methods This study included 6870 female and 7411 male subjects, and 15 obesity and lipid-related indices were measured and calculated. NAFLD was diagnosed by abdominal ultrasound. The area under the curve (AUC) of 15 obesity and lipid-related indices were calculated by receiver operating characteristic (ROC) analysis. Results Among the 15 obesity and lipid-related indices, the TyG index-related parameters had the strongest association with NAFLD. ROC analysis showed that except for ABSI, the other 14 parameters had high predictive value in identifying NAFLD, especially in female and young subjects. Most notably, TyG index-related parameters performed better than other parameters in predicting NAFLD in most populations. In the female population, the AUC of TyG-WC for predicting NAFLD was 0.9045, TyG-BMI was 0.9084, and TyG-WHtR was 0.9071. In the male population, the AUC of TyG-WC was 0.8356, TyG-BMI was 0.8428, and TyG-WHtR was 0.8372. In addition, BMI showed good NAFLD prediction performance in most subgroups (AUC>0.8). Conclusions Our data suggest that TyG index-related parameters, LAP, HSI, BMI, and WC appear to be good predictors of NAFLD. Of these parameters, TyG index-related parameters showed the best predictive potential.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The usefulness of obesity and lipid-related indices to predict the presence of Non-alcoholic fatty liver disease

Sheng

Xie

et al. 2021

Lipids Health Dis

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“…Many studies have investigated the association between MetS and obesity-related indices among different populations [ 28 , 29 , 30 , 31 ]. However, no previous studies have investigated the relationship between obesity-related indices and BMD among hemodialysis (HD) patients with MetS.…”

Section: Introductionmentioning

confidence: 99%

Associations between Metabolic Syndrome and Obesity-Related Indices and Bone Mineral Density T-Score in Hemodialysis Patients

Wung

Chung

et al. 2021

JPM

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Previous studies have reported inconsistent results regarding the associations between metabolic syndrome (MetS) and obesity-related indices and bone mineral density (BMD). However, no previous studies have reported these associations among hemodialysis (HD) patients. The aims of this study were to investigate associations between MetS and its components and BMD T-score in HD patients and also between obesity-related indices and BMD T-score in HD patients with and without MetS. MetS was defined according to the Adult Treatment Panel III for Asians, and BMD T-score was calculated using dual-energy X-ray absorptiometry. Eight obesity-related indices were evaluated, including lipid accumulation product (LAP), visceral adiposity index (VAI), body adiposity index, conicity index (CI), body roundness index (BRI), abdominal volume index (AVI), waist-to-height ratio (WHtR), waist–hip ratio, and body mass index (BMI). One hundred and sixty-four patients undergoing HD were enrolled, and the prevalence of MetS was 61.6%. MetS was significantly associated with high lumbar spine and total hip T-scores. Regarding the MetS components, abdominal obesity and low HDL-C were significantly associated with high lumbar spine, femoral neck, and total hip T-scores; hypertriglyceridemia was significantly associated with high lumbar spine and total hip T-scores; hyperglycemia was significantly associated with a high lumbar spine T-score, whereas high blood pressure was not associated with T-score at any site. In the patients with MetS, BMI, WHtR, AVI, and BRI were significantly associated with T-score at all sites, and high CI, VAI, and LAP were also related to a high lumbar T-score. However, these indices were not associated with T-score at any site in patients without MetS. This study demonstrated positive associations between MetS and its five components and BMD T-score among HD patients. MetS, abdominal obesity, hypertriglyceridemia, and low HDL-cholesterol were associated with low risk of osteoporosis among the HD patients. Furthermore, we found that some obesity-related indices were associated with BMD T-score among HD patients with MetS but not in those without MetS. Our study highlights the importance of BMI, WHtR, AVI, and BRI in predicting the risk of osteoporosis among HD patients with MetS. In clinical practice, they can be easily calculated through simple anthropometric measurements and routine laboratory examinations and be used to quickly and conveniently assess the risk of osteoporosis among HD patients.

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“…These indices have been reported to be effective indicators of MetS in nonoverweight/obese adults, vegetarians and in Nigeria [11][12][13][14]. We recently identified associations between these obesity-related indices and nonalcoholic fatty liver disease and heavy metals [15,16]. However, few studies have investigated sex differences in the relationships among MetS and these obesity-related indices in patients with diabetes.…”

Section: Introductionmentioning

confidence: 99%

Sex Difference in the Associations among Obesity-Related Indices with Metabolic Syndrome in Patients with Type 2 Diabetes Mellitus

Jao

Wung

et al. 2021

Int. J. Med. Sci.

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Background:The aim of this study was to investigate the associations among obesity-related indices and MetS in diabetic patients, and explore sex differences in these associations. Methods: Patients with type 2 DM were included from two hospitals in southern Taiwan. The Adult Treatment Panel III criteria for an Asian population were used to define MetS. In addition, the following obesity-related indices were evaluated: waist-to-height ratio, waist-hip ratio (WHR), conicity index (CI), body mass index (BMI), body roundness index, body adiposity index, lipid accumulation product (LAP), abdominal volume index, visceral adiposity index (VAI), abdominal volume index and triglyceride-glucose index. Results: A total of 1,872 patients with type 2 DM (mean age 64.0 ± 11.3 years, 808 males and 1,064 females) were enrolled. The prevalence rates of MetS were 59.8% and 76.4% in the males and female (p < 0.001), respectively. All of the obesity-related indices were associated with MetS in both sex (all p < 0.001). LAP and BMI had the greatest areas under the receiver operating characteristic curves in both sex. In addition, the interactions between BMI and sex (p = 0.036), WHR and sex (p = 0.016), and CI and sex (p = 0.026) on MetS were statistically significant. Conclusions:In conclusion, this study demonstrated significant relationships between obesity-related indices and MetS among patients with type 2 DM. LAP and VAI were powerful predictors in both sex. The associations of BMI, WHR and CI on MetS were more significant in the men than in the women.

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Gender Differences in the Relationships among Metabolic Syndrome and Various Obesity-Related Indices with Nonalcoholic Fatty Liver Disease in a Taiwanese Population

Cited by 42 publications

References 59 publications

The usefulness of obesity and lipid-related indices to predict the presence of Non-alcoholic fatty liver disease

The usefulness of obesity and lipid-related indices to predict the presence of Non-alcoholic fatty liver disease

Associations between Metabolic Syndrome and Obesity-Related Indices and Bone Mineral Density T-Score in Hemodialysis Patients

Sex Difference in the Associations among Obesity-Related Indices with Metabolic Syndrome in Patients with Type 2 Diabetes Mellitus

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