Gender Differences in the Susceptibility to Renal Ischemia-Reperfusion Injury in BALB/c Mice

Hu, Honglin; Wang, Gongxian; Batteux, Frédéric; Nicco, Carole

doi:10.1620/tjem.218.325

Cited by 28 publications

(21 citation statements)

References 21 publications

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“…In the present study renal injury markers were significantly higher in the I/R male group than in the I/R female group, supporting the high mortality in the I/R male group. These results are in line with Robert et al (2011), Rusai et al (2011) and Hu et al (2009.…”

Section: Discussionsupporting

confidence: 88%

Gender difference in the development of cardiac lesions following acute ischemic-reperfusion renal injury in albino rats

Ibrahim¹,

Elbassuoni²,

Ragy³

et al. 2014

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Abstract. Renal ischemia-reperfusion (I/R) is the major cause of acute renal failure. Renal I/R have distant effects on other organs, especially the heart. The purpose of this study was to investigate cardiac lesion following bilateral renal ischemia (50 minutes) and reperfusion (48 hours) in adult rats, to test sex differences in the development of cardiac lesions after acute renal I/R and to investigate the effect of estrogen on this type of cardiac lesions. 70 adult albino rats were divided into 7 groups: control male, I/R male, control female, I/R female, female with bilateral ovariectomy, I/R female with bilateral ovariectomy and I/R female with bilateral ovariectomy treated with estrogen. Renal and cardiac functions in both sexes were deteriorated following acute renal I/R injury proved by the increase in serum urea, creatinine, lactate dehydrogenase and creatine kinase levels. These cardiac lesions are mainly due to the oxidative stress response in the form of the increase in cardiac tissue lipid peroxide, and the decrease in cardiac tissue glutathione reductase, superoxide dismutase and catalase levels. In conclusion, female rats are more protected from the renal and cardiac lesions following acute renal I/R injury than male, since estrogen significantly decreases these lesions mainly by inhibiting the oxidative stress response.

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Section: Discussionsupporting

confidence: 88%

Gender difference in the development of cardiac lesions following acute ischemic-reperfusion renal injury in albino rats

Ibrahim¹,

Elbassuoni²,

Ragy³

et al. 2014

gpb

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“…The magnitude of IRI protection observed in C57BL/6 female mice was large, with females tolerating nearly twice the period of ischemia as males to attain an equivalent injury, consistent with the differential renal IRI tolerance described in other murine backgrounds (14). Since small differences in timing or temperature of renal IRI convey substantial differences in injury in the mouse model, a near-doubling of the duration of renal IRI tolerance is remarkable.…”

Section: Discussionsupporting

confidence: 72%

“…Generally, there is consensus that female sex conveys greater tolerance of, or protection from, IRI relative to the male sex. Investigations have focused on the effects of estrogen and testosterone on the intrinsic tissue tolerance of ischemia through differential expression of oxidative scavengers, HSPs, or other mediators (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). Moreover, a number of reports describe sex differences in the development of chronic injury patterns in animal transplant models (15,24,25).…”

Section: Introductionmentioning

confidence: 99%

Improved renal ischemia tolerance in females influences kidney transplantation outcomes

Aufhauser¹,

Wang²,

Murken³

et al. 2016

Journal of Clinical Investigation

123

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“…Renal ischemia-reperfusion was induced by bilateral clamping of the renal arteries for 45 min followed by reperfusion for 24 h. Briefly, following abdominal incisions, renal pedicles were bluntly dissected. For mice subjected to ischemia-reperfusion, bilateral renal pedicles occlusion for 45 min (pilot studies were performed using 30 and 35 min of ischemia, but these periods of time didn't lead to severe, reproducible increments in serum creatinine and BUN in our model [12]) was performed using microvascular clamps, which were used to clamp the renal pedicles. Reperfusion commenced once the artery clamps were removed.…”

Section: Methodsmentioning

confidence: 99%

MicroRNA-21 Attenuates Renal Ischemia Reperfusion Injury via Targeting Caspase Signaling in Mice

Jiang

et al. 2014

Am J Nephrol

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Background: MicroRNAs (miR) have come into focus as powerful regulators of gene expression and potential diagnostic tools during renal ischemia reperfusion injury (IRI). The aim of this study was to investigate the molecular regulation and function of miR-21, and to analyze the relationship between caspases and miR-21 expression levels in an experimental model of renal IRI. Methods: IRI was induced by bilateral renal ischemia for 45 min followed by reperfusion. The male BALB/c mice were randomly assigned to the following groups: pre-miR-21 + IRI group, antagomiR-21 + IRI group, PBS + IRI group, pre-miR-21 + sham operation group, antagomiR-21 + sham operation group, PBS + sham operation group. The pre-miR-21 or antagomiR-21 was administered intraperitoneally (200 ng/kg weight) 24 and 6 h before induction of ischemia. Renal function, histological damage, renal cell apoptosis proteins were evaluated at 24 h after reperfusion. Results: Mice upregulated miR-21 had lower plasma levels of blood urea nitrogen (BUN) and creatinine, lower histopathological scores and a decrease in programmed cell death 4 (PDCD4) mRNA and active caspase-3, caspase-8 proteins expressions. Conclusions: miR-21 is endowed with anti-apoptotic properties by suppressing the expression of PDCD4 gene and active caspase 3/8 fragments in the condition of renal IRI. miR-21 exerts significant functional protection in our renal murine model of IRI.

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Gender Differences in the Susceptibility to Renal Ischemia-Reperfusion Injury in BALB/c Mice

Cited by 28 publications

References 21 publications

Gender difference in the development of cardiac lesions following acute ischemic-reperfusion renal injury in albino rats

Gender difference in the development of cardiac lesions following acute ischemic-reperfusion renal injury in albino rats

Improved renal ischemia tolerance in females influences kidney transplantation outcomes

MicroRNA-21 Attenuates Renal Ischemia Reperfusion Injury via Targeting Caspase Signaling in Mice

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Gender Differences in the Susceptibility to Renal Ischemia-Reperfusion Injury in BALB/c Mice

Cited by 28 publications

References 21 publications

Gender difference in the development of cardiac lesions following acute ischemic-reperfusion renal injury in albino rats

Gender difference in the development of cardiac lesions following acute ischemic-reperfusion renal injury in albino rats

Improved renal ischemia tolerance in females influences kidney transplantation outcomes

MicroRNA-21 Attenuates Renal Ischemia Reperfusion Injury via Targeting Caspase Signaling in Mice

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Gender difference in the development of cardiac lesions following acute ischemic-reperfusion renal injury in albino rats

Gender difference in the development of cardiac lesions following acute ischemic-reperfusion renal injury in albino rats