Gender differences in trace element exposures with cognitive abilities of school-aged children: a cohort study in Wujiang city, China

Wang, Yihong; Wang, Yaqian; Yan, Chen‐Hua

doi:10.1007/s11356-022-20353-4

Cited by 6 publications

(3 citation statements)

References 89 publications

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“…Some prior observational studies have indicated that the serum concentration of some essential TE might be associated with age or gender [51,65,66]. However, no significant differences in Se, Zn, or Cu status were noted when comparing the male and female paediatric patients in our study.…”

Section: Discussioncontrasting

confidence: 67%

Selenium Status in Paediatric Patients with Neurodevelopmental Diseases

et al. 2022

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Neurodevelopmental diseases are often associated with other comorbidities, especially inflammatory processes. The disease may affect the trace element (TE) status, which in turn may affect disease severity and progression. Selenium (Se) is an essential TE required for the biosynthesis of selenoproteins including the transporter selenoprotein P (SELENOP) and extracellular glutathione peroxidase (GPX3). SELENOP deficiency in transgenic mice resulted in a Se status-dependent phenotype characterized by impaired growth and disturbed neuronal development, with epileptic seizures on a Se-deficient diet. Therefore, we hypothesized that Se and SELENOP deficiencies may be prevalent in paediatric patients with a neurodevelopmental disease. In an exploratory cross-sectional study, serum samples from children with neurodevelopmental diseases (n = 147) were analysed for total serum Se, copper (Cu), and zinc (Zn) concentrations as well as for the TE biomarkers SELENOP, ceruloplasmin (CP), and GPX3 activity. Children with epilepsy displayed elevated Cu and Zn concentrations but no dysregulation of serum Se status. Significantly reduced SELENOP concentrations were found in association with intellectual disability (mean ± SD (standard deviation); 3.9 ± 0.9 mg/L vs. 4.4 ± 1.2 mg/L, p = 0.015). A particularly low GPX3 activity (mean ± SD; 172.4 ± 36.5 vs. 192.6 ± 46.8 U/L, p = 0.012) was observed in phacomatoses. Autoantibodies to SELENOP, known to impair Se transport, were not detected in any of the children. In conclusion, there was no general association between Se deficiency and epilepsy in this observational analysis, which does not exclude its relevance to individual cases. Sufficiently high SELENOP concentrations seem to be of relevance to the support of normal mental development. Decreased GPX3 activity in phacomatoses may be relevant to the characteristic skin lesions and merits further analysis. Longitudinal studies are needed to determine whether the observed differences are relevant to disease progression and whether correcting a diagnosed TE deficiency may confer health benefits to affected children.

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Section: Discussioncontrasting

confidence: 67%

Selenium Status in Paediatric Patients with Neurodevelopmental Diseases

et al. 2022

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“…prospective mother–child cohorts). Thirty‐nine further studies were not selected as they did not meet the inclusion criteria (Calderon et al., 2001 ; Cusick et al., 2018 ; de Assis Araujo et al., 2022 ; de Water et al., 2022 ; do Nascimento et al., 2015 ; Forns et al., 2014 ; Freire et al., 2018 ; Hsueh et al., 2020 ; Huang et al., 2011 ; Jiang et al., 2018 , 2022 ; Khan et al., 2012 , 2019 ; Langley et al., 2015 ; Levin‐Schwartz et al., 2019 ; Lin et al., 2013 ; Lucchini et al., 2019 ; McDermott et al., 2012 ; Merced‐Nieves et al., 2022 ; Nahar, Inaoka, & Fujimura, 2014 ; Nahar, Inaoka, Fujimura, Watanabe, et al., 2014 ; Nozadi et al., 2021 ; Nyanza et al., 2021 ; Parajuli et al., 2013 , 2014 , 2015 ; Rahman et al., 2015 ; Renzetti et al., 2021 ; Rocha‐Amador et al., 2007 ; Rodríguez‐Barranco et al., 2016 ; Saxena et al., 2022 ; Valeri et al., 2017 ; Vibol et al., 2015 ; Wang, Wang, et al., 2007 ; Wang, Liu, et al., 2018 ; Wang, Wang, & Yan, 2022 ; Wasserman et al, 2011 ; Wright et al., 2006 ). Table 20 summarises the selected studies from both the 2009 Opinion and the current evaluation.…”

Section: Assessmentmentioning

confidence: 99%

Update of the risk assessment of inorganic arsenic in food

Schrenk,

Bignami,

Bodin

et al. 2024

EFS2

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The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard assessment of inorganic arsenic (iAs) and using the revised exposure assessment issued by EFSA in 2021. Epidemiological studies show that the chronic intake of iAs via diet and/or drinking water is associated with increased risk of several adverse outcomes including cancers of the skin, bladder and lung. The CONTAM Panel used the benchmark dose lower confidence limit based on a benchmark response (BMR) of 5% (relative increase of the background incidence after adjustment for confounders, BMDL05) of 0.06 μg iAs/kg bw per day obtained from a study on skin cancer as a Reference Point (RP). Inorganic As is a genotoxic carcinogen with additional epigenetic effects and the CONTAM Panel applied a margin of exposure (MOE) approach for the risk characterisation. In adults, the MOEs are low (range between 2 and 0.4 for mean consumers and between 0.9 and 0.2 at the 95th percentile exposure, respectively) and as such raise a health concern despite the uncertainties.

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“…Observational clinical studies have shown harmful effects from early developmental exposures [2]. Numerous studies have suggested that environmental trace elements can impact the development of intelligence quotient (IQ) in children [3][4][5]. Some of these environmental heavy metals, such as lead (Pb), cadmium (Cd), manganese (Mn), tin (Sn), antimony (Sb), arsenic (As), and titanium (Ti), may contribute to reduced IQ levels [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of School-Age Children’s Intelligence Quotient and Their Chronic Exposure to Trace Elements in Ambient Air

Adly¹,

Saati²,

Khafagy³

et al. 2023

Cureus

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BackgroundChildren's exposure to different trace elements in their air, water, and food or even present in paints or toys can affect their intelligence quotient (IQ) score. However, this correlation needs to be analyzed and evaluated in different contexts. This study aimed to investigate the associations between airborne concentrations of lead (Pb), manganese (Mn), cadmium (Cd), chromium (Cr), and arsenic (As) and intellectual function in school-age children in Makkah, Kingdom of Saudi Arabia. MethodologyOur cohort study aimed to explore the link between exposure to various trace elements in the surrounding air and the IQ scores of children residing in the vicinity of Makkah. We included 430 children in the study and collected information about demographic and lifestyle factors using a structured questionnaire. We employed a mini volume sampler (MiniVol, AirMetrics, Springfield, OR, USA) to collect 24-hour PM10 samples from five locations in Makkah, representing various residential areas with small-to-medium industrial activities and traffic load. We analyzed the samples for Pb, Mn, Cd, Cr, and As concentrations using inductively coupled plasma-mass spectrometry with Perkin Elmer 7300 (Perkin Elmer, Waltham, MA, USA). The combined impact of heavy metals on continuous outcomes was assessed using the Bayesian kernel machine regression model. ResultsThe mean atmospheric concentrations of Pb, Mn, Cd, Cr, and As in summer were 0.093, 0.006, 0.36, 0.15, and 0.017 µg/m 3 , respectively, while in winter, they were 0.004, 0.003, 0.12, 0.006, and 0.01 µg/m 3 , respectively. The findings of our study revealed that children's IQ scores were independently associated with co-exposure to the five metals, namely, Pb, Mn, Cd, Cr, and As. ConclusionsThis study demonstrates a link between combined exposure to five heavy metals (Pb, Mn, Cd, Cr, and As) and children's IQ scores. Regularly evaluating trace elements in children's biological samples is crucial to comprehend their effects on cognitive growth. To explore the possible future health risks of multimetal exposures and their interaction effects, it is imperative to conduct additional studies that involve repeated biological measurements of metal concentrations.

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Gender differences in trace element exposures with cognitive abilities of school-aged children: a cohort study in Wujiang city, China

Cited by 6 publications

References 89 publications

Selenium Status in Paediatric Patients with Neurodevelopmental Diseases

Selenium Status in Paediatric Patients with Neurodevelopmental Diseases

Update of the risk assessment of inorganic arsenic in food

Evaluation of School-Age Children’s Intelligence Quotient and Their Chronic Exposure to Trace Elements in Ambient Air

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