Gender Disparities in Ocular Inflammatory Disorders*

Sen, H. Nida; Davis, Janet L.; Uçar, Didar; Fox, Austin; Chan, Chi Chao; Goldstein, Debra A.

doi:10.3109/02713683.2014.932388

Cited by 23 publications

(34 citation statements)

References 141 publications

(156 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…Prior studies have shown that ocular inflammatory disorders have a higher incidence in women compared with men, particularly in women of childbearing age, and that this gender difference increases with increasing age [ 17 ]. Sex hormones and the presence of an extra X chromosome in women are thought to play important roles in the development of these immune-mediated diseases [ 17 , 35 , 36 ]. While this gender difference has been found in studies performed in several developed countries [ 5 , 6 ], a reverse gender predilection has been noted in developing countries, such as India or Turkey, where a male predominance was found [ 14 , 15 , 19 – 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…Risk factors for the development of uveitis have been previously reported. It is well established that there is a higher incidence in women compared with men [ 17 ] and that the risk increases with older age [ 17 , 18 ], although the later has not been uniformly supported by studies [ 1 , 10 , 14 , 18 – 23 ]. Smoking has also been recently reported to be positively associated with the development of uveitis [ 24 , 25 ], as well as being a risk factor for active disease [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Epidemiology of uveitis in a US population-based study

González

Solano

Porco

et al. 2018

J Ophthal Inflamm Infect

View full text Add to dashboard Cite

BackgroundThe purpose of this study is to assess the relationship between self-reported uveitis and purported demographic and clinical risk factors, using an American adult population extracted from the National Health and Nutrition Examination Survey (NHANES) for the years 2009 and 2010. This is a cross-sectional, population-based study using a sample of 5106 subjects between 20 and 69 years old. The main outcome for our study was the self-report of a diagnosis of uveitis. The demographic analysis included age, gender, and ethnicity. Potential predictors were having a diagnosis of ankylosing spondylitis (AS), ulcerative colitis (UC), or Crohn’s disease (CD); a history of cigarette smoking; vitamin D deficiency; and different mental health measures. Univariate and multivariate analyses were conducted using RStudio.ResultsOf the 5106 participants, 27 had reported a diagnosis of uveitis, showing an adjusted prevalence of 5.4 per 1000 subjects (95% CI 3.4–8.5/1000). Increased age was associated with higher uveitis prevalence in the multivariate analysis (odds ratio [OR] = 1.04, 95% CI 1.01–1.07; p = 0.02). Positive smoking history was reported in 59.2% of patients. Multivariate analysis comparing smoking with the presence of uveitis showed an OR of 3.18 (95% CI 1.59–6.37; p = 0.003), adjusting for age and gender. Moreover, 11.1% of the participants from the uveitis group self-reported a diagnosis of AS and 11.7% informed a diagnosis of UC and 7.1% of CD. The ORs were of 16.64 (95% CI 3.64-76.09; p = 0.001), 11.34 (95% CI 2.69-47.88; p = 0.003), and 22.16 (95% CI 2.64-186.17; p = 0.007), respectively when compared with the non-uveitis group in the multivariate analysis.ConclusionsAge, cigarette smoking, AS, UC, and CD are positively associated with self-reported uveitis. There is previous evidence that smoking and female gender are positive risk factors for uveitis, as well as evidence that HLA-B27-positive spondyloarthritides have the highest association with non-infectious uveitis in the adult population in North America and Europe. However, there are no prior studies that have utilized a representative US population-based sample to validate these findings. The present study supports smoking as a risk factor, which has clinical relevance since this is a modifiable habit.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology of uveitis in a US population-based study

González

Solano

Porco

et al. 2018

J Ophthal Inflamm Infect

View full text Add to dashboard Cite

show abstract

“…31 Interestingly, 56% of cases are granulomatous and greater than 90% are bilateral. 34, 35 Uveitis, in particular, shows a female predisposition, though it is uncertain whether this is solely because MS is more common in females (upwards of 88% of MS patients with uveitis are female). 31, 34, 35 Idiopathic intermediate uveitis (IU) that often has similar clinical findings of MS is slightly more prevalent in females, with 56% of IU patients being female.…”

Section: Female Predominant Uveitides With Systemic Involvementmentioning

confidence: 99%

The Role of Sex in Uveitis and Ocular Inflammation

Yeung¹,

Popp²,

Chan³

2015

International Ophthalmology Clinics

View full text Add to dashboard Cite

Uveitides can be due to non-infectious and infectious etiologies. It has been observed that there is a gender difference with a greater preponderance of non-infectious uveitis in women than in men. This review will describe both non-infectious and infectious uveitides and describes some of the current autoimmune mechanisms thought to be underlying the gender difference. It will specifically look at non-infectious uveitides with systemic involvement including juvenile idiopathic arthritis, spondyloarthopathies, sarcoidosis, Behçet’s disease, and Vogt-Koyanagi-Harada disease and at uveitides without systemic involvement including sympathetic ophthalmia, birdshot chorioretinitis, and the white dot syndromes. Infectious uveitides like acute retinal necrosis, progressive outer retinal necrosis, and cytomegalovirus mediated uveitis will be mentioned. Different uveitides with female- or male- predominance are presented and discussed.

show abstract

“…Sex-based differences in incidence and/or prevalence have been observed in a number of ocular diseases [1–5]. In particular, those characterized by the aberrant growth of new blood vessels, such as diabetic retinopathy and age-related macular degeneration, have been shown to display a sex bias [6, 7].…”

Section: Introductionmentioning

confidence: 99%

Sex differences in corneal neovascularization in response to superficial corneal cautery in the rat

et al. 2019

View full text Add to dashboard Cite

Sex-based differences in susceptibility have been reported for a number of neovascular ocular diseases. We quantified corneal neovascularization, induced by superficial silver nitrate cautery, in male and female inbred albino Sprague-Dawley, inbred albino Fischer 344, outbred pigmented Hooded Wistar and inbred pigmented Dark Agouti rats of a range of ages. Corneal neovascular area was quantified on haematoxylin-stained corneal flatmounts by image analysis. Pro-and anti-angiogenic gene expression was measured early in the neovascular response by quantitative real-time polymerase chain reaction. Androgen and estrogen receptor expression was assessed by immunohistochemistry. Male rats from all strains, with or without ocular pigmentation, exhibited significantly greater corneal neovascular area than females: Sprague-Dawley males 43±12% (n = 8), females 25±5% (n = 12), p = 0.001; Fischer 344 males 38±10% (n = 12) females 27±8% (n = 8) p = 0.043; Hooded Wistar males 32±6% (n = 8) females 22±5% (n = 12) p = 0.002; Dark Agouti males 37±11% (n = 9) females 26±7% (n = 9) p = 0.015. Corneal vascular endothelial cells expressed neither androgen nor estrogen receptor. The expression in cornea post-cautery of Cox-2 , Vegf-a and Vegf-r2 was significantly higher in males compared with females and Vegf-r1 was significantly lower in the cornea of males compared to females, p<0.001 for each comparison. These data suggest that male corneas are primed for angiogenesis through a signalling nexus involving Cox-2 , Vegf-a , and Vegf receptors 1 and 2. Our findings re-enforce that pre-clinical animal models of human diseases should account for sex-based differences in their design and highlight the need for well characterized and reproducible pre-clinical studies that include both male and female animals.

show abstract

Gender Disparities in Ocular Inflammatory Disorders*

Cited by 23 publications

References 141 publications

Epidemiology of uveitis in a US population-based study

Epidemiology of uveitis in a US population-based study

The Role of Sex in Uveitis and Ocular Inflammation

Sex differences in corneal neovascularization in response to superficial corneal cautery in the rat

Contact Info

Product

Resources

About