Gender, Estrogen, and Obliterative Lesions in the Lung

Assaggaf, Hamza; Felty, Quentin

doi:10.1155/2017/8475701

Cited by 11 publications

(5 citation statements)

References 128 publications

(135 reference statements)

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“…All three forms of oestrogen are transported in the bloodstream either bound to sex hormone-binding globulin or in the unbound state [ 23 ] before binding to either oestrogen receptors (ER) α or β expressed on the cell surface of the target tissue [ 24 ]. Notably, both oestrogen receptors are expressed in lung epithelia, airway smooth muscle and the pulmonary vasculature [ 25 , 26 ]. The activated oestrogen/ER complex has been implicated in fetal alveologenesis and surfactant production, pulmonary arterial hypertension, airway hyperresponsiveness and pulmonary inflammation [ 25 ].…”

Section: Physiology Of Female Sex Hormonesmentioning

confidence: 99%

“…Notably, both oestrogen receptors are expressed in lung epithelia, airway smooth muscle and the pulmonary vasculature [ 25 , 26 ]. The activated oestrogen/ER complex has been implicated in fetal alveologenesis and surfactant production, pulmonary arterial hypertension, airway hyperresponsiveness and pulmonary inflammation [ 25 ].…”

Section: Physiology Of Female Sex Hormonesmentioning

confidence: 99%

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Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes

et al. 2020

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Sex differences in morbidity and mortality have been reported in the cystic fibrosis (CF) population worldwide. However, it is unclear why CF women have worse clinical outcomes than men. In this review, we focus on the influence of female sex hormones on CF pulmonary outcomes and summarise data from in vitro and in vivo experiments on how estrogen and progesterone might modify mucociliary clearance, immunity and infection in the CF airways. The potential for novel sex hormone related therapeutic interventions is also discussed.

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Section: Physiology Of Female Sex Hormonesmentioning

confidence: 99%

Section: Physiology Of Female Sex Hormonesmentioning

confidence: 99%

Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes

et al. 2020

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“…In the past decade, several clinical and basic science studies have been conducted in order to elucidate the specific roles that male and female sex hormones play in lung inflammatory processes. 2,3 Here, we discuss the most recent literature available describing sex differences in inflammatory lung disease prevalence and outcomes, with a particular emphasis on asthma and COPD, which show a clear sexual dimorphism in prevalence and incidence. 4,5 We also summarize the results from multiple studies focused on understanding the roles of sex hormones as modulators of lung function and inflammation using different experimental models.…”

Section: Introductionmentioning

confidence: 99%

Endocrine regulation of lung disease and inflammation

Fuentes

Silveyra

2018

Exp Biol Med (Maywood)

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Sex-based disparities have been identified in respiratory physiology, and in many chronic lung diseases including asthma, chronic obstructive pulmonary disease, and cystic fibrosis. The observed sex differences in lung disease prevalence and incidence have been linked to changes in circulating levels of sex hormones that start after puberty and that have been shown to affect physiological and immunological functions. While the exact roles of male and female sex hormones in these processes have not been fully elucidated, it is now evident that these can target many lung cell types and affect several functions of the respiratory system. In this mini-review, we have summarized seminal studies aimed to understand the effects of the most relevant male and female sex hormones (estrogens, progesterone, and androgens) and their receptors on lung function. Moreover, we have reviewed the known influences of sex hormones and of the hypothalamic–pituitary–gonadal axis in lung disease and immunity. Understanding the roles of sex hormones in the regulation of lung function and inflammation is the first step for the potential development of more effective therapeutic options to prevent and treat lung disease in men and women. Impact statement Sex-differences in the incidence and severity of inflammatory lung diseases have been recognized for years. Women of reproductive age are more likely to suffer from chronic lung disease, with higher mortality rates than men. Physiological changes in hormone levels such as those occurring during the menstrual cycle, pregnancy, and menopause have been associated with lung function changes and asthma symptoms. Despite this, the roles of sex hormones in the mechanisms associated with lung diseases have not been fully elucidated. This review summarizes basic and clinical studies of sex hormones as potential modulators of lung function and inflammation. The information obtained from sex-specific research on lung physiology and pathology will potentially help in the development of sex-specific therapeutics for inflammatory lung disease that may account for the hormonal status of the patient.

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“…Several studies aimed to understand the role of sex hormones in lung inflammatory processes [20]. Asthma is a chronic inflammatory disease characterized by a sexual dimorphism.…”

Section: Discussionmentioning

confidence: 99%

The Role of Airways 17β-Estradiol as a Biomarker of Severity in Postmenopausal Asthma: A Pilot Study

Scioscia

Carpagnano

Lacedonia

et al. 2020

JCM

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Background: Asthma severity differs according to gender; in adult women, there is higher prevalence and severity of asthma than in men, and it coincides with changes in sex hormones. Recently, a new phonotype of asthma has been identified that appears after menopause, and it may be associated with decreased estrogen levels. Our goal was to study the 17β-estradiol (E2) concentrations in the blood and airways of women affected by asthma onset after menopause, evaluating its possible role in the severity of the disease. Methods: We enrolled 33 consecutive women with a diagnosis of postmenopausal asthma, recruited from the outpatient pulmonary clinic: 18 with severe (SA) and 15 with mild-to-moderate (MMA) asthma. We also included 30 age-matched healthy menopausal women as controls (HS). All subjects enrolled underwent blood and sputum collection (IS), and E2 concentrations were determined in plasma and sputum supernatant samples using an enzyme-linked immunosorbent assay (ELISA) kit. Results: Significantly higher serum concentrations of E2 were found in postmenopausal SA compared to MMA and HS, respectively (33 ± 5.5 vs. 24 ± 6.63 vs. 7.79 ± 1.54 pg/mL, p < 0.05). Similar results were found in the IS: significantly higher levels of E2 were detected in patients with postmenopausal SA compared with MMA and HS, respectively (0.34 ± 0.17 vs. 0.26 ± 0.13 vs. 0.07 ± 0.06 pg/mL, p < 0.05). We found positive correlations between IS E2 concentrations and sputum neutrophil levels in SA group (ρ = 0.52, p < 0.05). Conclusions: Our findings showed the possibility to measure E2 in the airways, and it has increased in postmenopausal asthmatic patients, especially in those with SA. Airways E2 levels may serve as a suitable biomarker of postmenopausal SA to help to phenotype SA patients with neutrophil inflammation.

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Gender, Estrogen, and Obliterative Lesions in the Lung

Cited by 11 publications

References 128 publications

Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes

Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes

Endocrine regulation of lung disease and inflammation

The Role of Airways 17β-Estradiol as a Biomarker of Severity in Postmenopausal Asthma: A Pilot Study

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