Gender Features of Markers of Endothelial Damage, Oxidative and Cellular Stress in Comorbid CHD Patients

Abstract

The main morbidity and mortality in the world is caused by cardiovascular diseases. In the structure of CVD, the largest percentage is coronary heart disease. The main cause of CHD is atherosclerosis. To date, it is believed that the prognosis of patients with stable coronary heart disease is primarily due to the severity of coronary atherosclerosis. But do not forget about the presence of comorbid pathology in patients, which is becoming increasingly relevant and has an impact on the quality of life of such patients. In addition, it is necessary to keep in mind the gender characteristics of the development of CHD and the adherence of patients with CHD to the treatment and diagnosis of their disease, depending on gender. The aim of the study was to study the gender characteristics of coronary atherosclerosis, changes in markers of endothelial damage, oxidative and cellular stress in comorbid CHD patients. The material for the study was a survey of 336 patients diagnosed with coronary heart disease, verified by standardized validated criteria and clinical and functional methods. The presence of coronary atherosclerosis in patients was confirmed by coronary angiography using the Judkins method. The severity of coronary atherosclerosis was determined based on the Gensini index. Gender differences in indicators of oxidative stress, cellular stress, inflammation and endothelial dysfunction were revealed. Analysis of the relationship between sex and the studied indicators revealed significant positive associations with the Gensini index and male sex, as well as with markers of oxidative stress; and significant negative associations with superoxide dismutase activity, as well as heat shock proteins 70.