Research shows that higher education faculty face diminished subjective well-being (SWB), leading to negative consequences—not only for themselves, but also for students and institutions. Therefore, their ability to cope well with the work demands and responsibilities they face is crucial. Despite the importance of SWB and coping for this population, little is known about individual differences in these factors. To address this, we analyzed cross-sectional data on SWB, coping, and personal/demographic variables of 803 faculty members from 52 universities. Results of the multivariate analyses of variance attested significant differences in SWB and coping depending on gender and academic position. Furthermore, teaching experience and gender were found to interact with SWB and coping. Thus, faculty members who have little teaching experience and who are women can particularly benefit in interventions on SWB and coping.