Gender-related association among childhood maltreatment, brain structure and clinical features in bipolar disorder

Čolić, Lejla; Clark, Alexis; Sankar, Anjali; Rathi, Durga J.; Goldman, Danielle; Kim, Jihoon A.; Villa, Luca M; Edmiston, E. Kale; Lippard, Elizabeth; Pittman, Brian; Constable, R. Todd; Mazure, Carolyn M.; Blumberg, Hilary P.

doi:10.1016/j.euroneuro.2022.07.186

Cited by 4 publications

(2 citation statements)

References 56 publications

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“…A meta-analysis of Agnew-Blais et al also reported that depressive, manic, and psychotic symptoms of BD were all positively associated with childhood trauma, and the number of depressive and manic episodes was also positively associated with childhood trauma [ 12 ]. Colic et al found that females with BD experienced more severe childhood trauma than males with BD [ 13 ]. Although researchers have recognized the role of childhood trauma in bipolar disorder, most studies were conducted in BD patients with medication, and there is a lack of literature comparing self-report childhood trauma between drug-naïve BD patients and those with medication.…”

Section: Introductionmentioning

confidence: 99%

Association of childhood trauma, social support, cognition, and suicidality in females with bipolar disorder

Yang,

Li,

et al. 2024

BMC Psychiatry

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Background Bipolar disorder (BD) is a severe mental disorder with heavy disease burden. Females with BD are special populations who suffer a lot from childhood trauma, social support, cognitive deficits, and suicidality. In this study, the relationship among childhood trauma, social support, and clinical symptoms of BD was investigated and the risk factors for suicidality were explored in female patients with BD. Methods This study included 57 drug-naive female BD patients, 64 female BD patients with long-term medication, and 50 age-matched female healthy controls. Childhood trauma, social support, clinical symptoms, cognition, and suicidality (suicide ideation, suicide plan, suicide attempt, suicide frequency) were measured with scales. Results Compared with healthy controls, females with BD showed higher levels of childhood trauma and suicidality, and lower levels of social support and cognitive deficits. In the drug-naïve BD group, social support mediated the relationship between childhood trauma and insomnia symptoms (indirect effect: ab = 0.025). In the BD with long-term medication group, mania symptom was associated with suicide plan (OR = 1.127, p = 0.030), childhood trauma was associated with suicide attempt (OR = 1.088, p = 0.018), and years of education (OR = 0.773, p = 0.028), childhood trauma (OR = 1.059, p = 0.009), and delayed memory (OR= 1.091, p= 0.016) was associated with suicide frequency (OR = 1.091, p = 0.016). Conclusions This study provides initial evidence that social support partially explains the relationship between childhood trauma and clinical symptoms in females with BD. Additionally, mania symptoms, childhood trauma, and delayed memory were risk factors for suicidality. Interventions providing social support and improving cognitive function may be beneficial for females with BD who are exposed to childhood trauma and with high suicide risk.

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Section: Introductionmentioning

confidence: 99%

Association of childhood trauma, social support, cognition, and suicidality in females with bipolar disorder

Yang,

Li,

et al. 2024

BMC Psychiatry

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“…Studies reported that the adverse effects of childhood trauma on females were stronger than on males (20,21), suggesting that females are more vulnerable to childhood trauma (22). Colic et al found that females with BD experienced childhood trauma more severely than males with BD (23). Additionally, childhood trauma had a negative effect on the onset of BD but a positive effect on the duration of treatment in females with BD (24).…”

Section: Introductionmentioning

confidence: 99%

A mediator between childhood trauma and clinical symptoms in females with bipolar disorder: social support

Yang,

Li,

et al. 2023

Preprint

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Background Bipolar disorder (BD) is a severer mental disorder with gender differences. Both childhood trauma and social support play important roles in the BD course, especially in female patients. In this study, the relationship between childhood trauma and clinical symptoms of BD was investigated in female patients and the mediation effect of social support on this relationship. Methods This study included 57 females with BD and 53 age-matched healthy controls. The measurement of childhood trauma, social support, and clinical symptoms were measured using self-report questionnaires and clinical scales. Results Compared with healthy controls, females with BD showed higher levels of childhood trauma and lower levels of social support. In the BD group, high levels of childhood trauma were positively correlated with clinical symptoms. In addition, social support mediated the relationship between childhood trauma and clinical symptoms of BD, except for manic symptoms. Conclusions Studies should focus on the role of childhood trauma and social support in females with bipolar disorder. This study provides initial evidence that social support partially explains the relationship between childhood trauma and clinical symptoms of BD. Interventions providing social support may be beneficial for females with BD exposed to childhood trauma.

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Social cognition in maltreated individuals: Do type and timing of maltreatment matter?

Fares-Otero,

Schalinski

2024

European Neuropsychopharmacology

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Gender-related association among childhood maltreatment, brain structure and clinical features in bipolar disorder

Cited by 4 publications

References 56 publications

Association of childhood trauma, social support, cognition, and suicidality in females with bipolar disorder

Association of childhood trauma, social support, cognition, and suicidality in females with bipolar disorder

A mediator between childhood trauma and clinical symptoms in females with bipolar disorder: social support

Social cognition in maltreated individuals: Do type and timing of maltreatment matter?

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