Gender‐Related Changes of the Epicardial Fat Thickness and Leptin in Obstructive Sleep Apnea

Akıllı, Hakan; Kayrak, Mehmet; Bekçi, Taha Tahir; Erdoğan, Halil İbrahim; Arıbaş, Alpay; Yıldırım, Oğuzhan; Taner, Alpaslan; Erer, Murat; Ünlü, Ali

doi:10.1111/echo.12392

Cited by 20 publications

(18 citation statements)

References 48 publications

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“…Leptin concentrations in women are higher than in men [24]. In a cross-sectional study in severely untreated OSAS patients using single leptin measurements, OSAS severity was related to leptin concentrations among females, but not in males [25]. In our study, leptin concentrations did not differ between males and females at baseline; whereas during the follow-up, increase in leptin concentrations was higher among females compared with males.…”

Section: Discussioncontrasting

confidence: 65%

Gender-specific change in leptin concentrations during long-term CPAP therapy

et al. 2019

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Purpose Nasal continuous positive airway pressure (CPAP) alleviates sleepiness in patients with obstructive sleep apnoea syndrome (OSAS), but part of OSAS patients keep gaining weight. Leptin and insulin-like growth factor-1 (IGF-1) interact with energy balance, and CPAP therapy has been suggested to influence these endocrine factors. We hypothesised that leptin would decrease during long-term CPAP therapy, and weight gain would associate with OSAS severity, lower CPAP adherence, lower IGF-1, and leptin concentrations. Methods Consecutive patients (n = 223) referred to sleep study with suspected OSAS were enrolled. Patients underwent cardiorespiratory polygraphy at baseline. Questionnaires were completed, and blood samples were drawn both at baseline and after 3 years. A total of 149 (67%; M 65, F 84) patients completed the follow-up. Plasma samples were available from 114 patients, 109 of which with CPAP adherence data (49 CPAP users, 60 non-users).Results At baseline, the CPAP users were more obese and had more severe OSAS than the non-users. Leptin concentrations did not differ. After follow-up, leptin concentrations were higher in CPAP users (30.2 ng/ml vs. 16.8 ng/ml; p = 0.001). In regression analysis, increase in leptin concentrations was independent of age, baseline body mass index (BMI), or the change in BMI. Leptin concentrations increased among females (− 8.9 vs. 12.7 ng/ml; p < 0.001); whereas in men, CPAP did not have an effect, if not opposed the natural decrease in leptin observed in men not using CPAP. Change in IGF-1 levels did not differ. Conclusions Our results suggest increase in leptin concentrations during long-term CPAP therapy among females.

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Section: Discussioncontrasting

confidence: 65%

Gender-specific change in leptin concentrations during long-term CPAP therapy

et al. 2019

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“…Iacobellis et al showed bigger size of EFT in males than in females [ 17 ], and our result showed the greater values of EFT in females. Recent study by Akilli et al [ 25 ] showed larger EFT in females than in males. Thus, these findings may indicate different gender susceptibilities related to obesity and the regional differences in fat distribution, especially EFT distribution.…”

Section: Discussionmentioning

confidence: 99%

Impact of Gender on the Association of Epicardial Fat Thickness, Obesity, and Circadian Blood Pressure Pattern in Hypertensive Patients

Shim

Cho

Kim

et al. 2015

Journal of Diabetes Research

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This study aimed to investigate the effects of gender on the association between epicardial fat thickness (EFT) and circadian blood pressure (BP) changes in patients with recently diagnosed essential hypertension (EH). A total of 441 patients with EH (male/female: 236/205, mean age: 50.7 ± 13.8) and 83 control patients underwent 24-hour ambulatory BP monitoring and echocardiography. Obese EH patients had higher circadian BP profile with BP variability, wall thickness, and left ventricular mass than nonobese EH patients and controls (all p's <0.05) without gender differences. EFT was higher in female than in male patients (7.0 ± 2.5 versus 5.9 ± 2.2 mm, p < 0.001) and higher in the obese female EH group (7.5 ± 2.6 mm) than in the control (6.4 ± 2.8 mm) or nonobese EH group (6.7 ± 2.8 mm) among women, whereas EFT did not vary among males (5.9 ± 1.9 versus 6.0 ± 2.7 versus 5.9 ± 2.4 mm, p = 0.937). Multivariate logistic regression analysis demonstrated that the 24-hour mean BP variability was associated with SBP (p = 0.018) and EFT (p = 0.016) in female patients, but not in male patients. The relationships among circadian BP variability, obesity, and EFT were affected by gender in different manners. EFT may be a more valuable parameter in the evaluation of BP severity and obesity in women than in men.

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“…Two previous studies demonstrated a possible association between EAT thickness and OSAHS severity in obese patients [18] and in OSAHS patients with and without metabolic syndrome [19]. Another study was found thicker EAT only in women with severe OSAHS [20].…”

Section: Introductionmentioning

confidence: 92%

CPAP therapy induces favorable short-term changes in epicardial fat thickness and vascular and metabolic markers in apparently healthy subjects with obstructive sleep apnea-hypopnea syndrome (OSAHS)

et al. 2015

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Gender‐Related Changes of the Epicardial Fat Thickness and Leptin in Obstructive Sleep Apnea

Abstract: Leptin and EFT may be a valuable parameter in the evaluation of OSA severity in women than in men.

Cited by 20 publications

References 48 publications

Gender-specific change in leptin concentrations during long-term CPAP therapy

Gender-specific change in leptin concentrations during long-term CPAP therapy

Impact of Gender on the Association of Epicardial Fat Thickness, Obesity, and Circadian Blood Pressure Pattern in Hypertensive Patients

CPAP therapy induces favorable short-term changes in epicardial fat thickness and vascular and metabolic markers in apparently healthy subjects with obstructive sleep apnea-hypopnea syndrome (OSAHS)

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