In the present article, we conducted an exploratory study of student persistence and performance in a key course in the engineering sequence (i.e., Statics). At issue was whether certain characteristics of students (i.e., their gender, SAT‐math scores, GPA) and institutions (i.e., class size, percentage of female enrollment, gender of instructor) would be associated with higher levels of persistence and performance. Students from 48 sections of Statics from 17 institutions were included in the study (N = 4,993 males and 1,123 females). Within‐gender analyses showed that the primary factors associated with persistence were GPAs and SAT‐math scores. Between‐gender analyses revealed that the size and direction of the gender gap in persistence varied across institutions. Factors associated with these variations included the selectivity of the institution and the relative level of female persistence.