Gender-Related Differences in HDL Structure with the Progression of Microalbuminuria in Patients with Type 2 Diabetes

Nakhjavani, Manouchehr; Larry, Mehrdad; Nargesi, Arash Aghajani; Mostafavi, Ebrahim; Mirmiranpour, Hossein; Esteghamati, Alireza

doi:10.15406/jdmdc.2015.02.00043

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…It showed that an increase in the ApoA1/HDL-C ratio was associated with the incidence of diabetes and was a primary risk factor for diabetes in both genders [ 26 ]. In addition, a case-control study by Nakhjavani et al showed that a higher ApoA1/ HDL-C ratio was correlated with microalbuminuria in females with T2D [ 35 ]. However, the association of this ratio with CAD in patients with T2D has yet to be reported.…”

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confidence: 99%

ApoA1/HDL-C ratio as a predictor for coronary artery disease in patients with type 2 diabetes: a matched case-control study

Ghaemi,

Rabizadeh,

Yadegar

et al. 2024

BMC Cardiovasc Disord

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Introduction This study investigated the possible relationship between the Apo lipoprotein A1 /high-density lipoprotein cholesterol (ApoA1/HDL-C) ratio and coronary artery disease (CAD) in patients with type 2 diabetes (T2D). Methods This was a matched case-control study of 482 patients with T2D in two groups of CAD and (n = 241) non-CAD (n = 241). The patients were classified into four quartiles according to the ApoA1/HDL-C ratio, and multivariate logistic regression analysis was performed to assess the relationship between ApoA1/HDL-C and CAD. ROC analysis was also conducted. Results This study showed that the ApoA1/HDL-C ratio has an independent association with CAD in individuals with T2D. The CAD group exhibited a significantly higher ApoA1/HDL-C ratio than those without CAD (p-value = 0.004). Moreover, the risk of CAD increased significantly across the ApoA1/HDL-C ratio quartiles, with the highest odds in the fourth quartile. The second quartile showed an odds ratio (OR) of 2.03 (p-value = 0.048) compared to the first. Moving to the third quartile, the OR increased to 2.23 (p-value = 0.023). The highest OR was noted in the fourth, reaching 3.41 (p-value = 0.001). Employing a cut-off value of 2.66 and an area under the curve (AUC) of 0.885, the ApoA1/HDL-C ratio predicts CAD among patients with T2D with a sensitivity of 75% and a specificity of 91% (p-value < 0.001). Conclusion The current study revealed an independent association between ApoA1/HDL-C ratio and CAD in patients with T2D. This ratio can be a promising tool for predicting CAD during the follow-up of patients with T2D, aiding in identifying those at higher risk for CAD.

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Section: Discussionmentioning

confidence: 99%

ApoA1/HDL-C ratio as a predictor for coronary artery disease in patients with type 2 diabetes: a matched case-control study

Ghaemi,

Rabizadeh,

Yadegar

et al. 2024

BMC Cardiovasc Disord

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The Impact of Aerobic Exercise on HDL Quantity and Quality: A Narrative Review

Franczyk

Gluba-Brzózka

Ciałkowska-Rysz

et al. 2023

IJMS

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High-density lipoproteins comprise roughly 25–30% of the circulating proteins involved in the transport of lipids in circulation. These particles differ in size and lipid composition. Recent evidence suggests that the quality of HDL particles (which depends on shape, size and the composition of proteins and lipids determining HDL functionality) may be more important than their quantity. The functionality of HDL is mirrored by its cholesterol efflux activity, as well as its antioxidant (including the protection of LDL against oxidation), anti-inflammatory and antithrombotic properties. The results of many studies and meta-analyses imply the beneficial impact of aerobic exercise on HDL-C levels. Physical activity was found to be usually associated with an increase in HDL cholesterol and a decrease in LDL cholesterol and triglycerides. Exercise, apart from inducing quantitative alterations in serum lipids, exerts a beneficial impact on HDL particle maturation, composition and functionality. The Physical Activity Guidelines Advisory Committee Report underlined the importance of establishing a program recommending exercises that enable attainment of maximal advantage at the lowest level of risk. The aim of this manuscript is to review the impact of different types of aerobic exercise (various intensities and durations) on the level and quality of HDL.

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Gender-Related Differences in HDL Structure with the Progression of Microalbuminuria in Patients with Type 2 Diabetes

Abstract: There are elevated levels of atherogenic lipid particles in diabetic women compared with men. 14-16 This is an important risk factor for

Cited by 2 publications

References 33 publications

ApoA1/HDL-C ratio as a predictor for coronary artery disease in patients with type 2 diabetes: a matched case-control study

ApoA1/HDL-C ratio as a predictor for coronary artery disease in patients with type 2 diabetes: a matched case-control study

The Impact of Aerobic Exercise on HDL Quantity and Quality: A Narrative Review

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