Gender related differences in patients presenting with acute heart failure. Results from EuroHeart Failure Survey II

Abstract

Aims: This analysis evaluates the gender differences in patients hospitalised for acute heart failure (AHF) in the EuroHeart Failure Survey II (EHFS). Results: Of the 3580 patients included in EHFS II, 1384 (39%) were women, mean age 73 years. 2196 (61%) were men, mean age 68 years. Women more frequently had new-onset AHF, hypertension and valvular disease and less frequently coronary heart disease or dilated cardiomyopathy compared with men. Smoking, chronic obstructive pulmonary disease, peripheral arterial disease and renal failure were less common, but diabetes and anaemia significantly more frequent in women. Atrial fibrillation and preserved left ventricular function were more common in women. Men were more often non-compliant with medication. After adjustment for indications and age, there were no significant gender differences in prescription of HF medication.All-cause readmission rate during the one-year follow-up was lower in women. However, the proportion of HF hospitalisation and oneyear mortality after discharge (20%) were similar in both genders. Conclusion: Women frequently present with new-onset AHF. A significant gender difference exists in aetiology, ventricular function and comorbidities. Women's use of HF medication has improved. These findings emphasize the importance of individualised management and need for more comprehensive recruitment of women in clinical trials.

Characteristics and outcomes of heart failure hospitalization before implementation of a heart failure clinic: The PRECIC study

“…In that study 73.2% of patients had HFrEF, which reflects considerable differences between the two study populations and is evidence of how observational studies provide valuable information about acute HF managed in different clinical scenarios. 20,21 Our data on gender are in agreement with other reports showing that elderly patients hospitalized with HF are mainly women 22 and that patients with HFpEF are older and more often female than those with HFrEF. 1,5,6,8,13 HF patients managed by internists are more likely to have the characteristics of those managed by general practitioners.…”

Ablation of cyclase-associated protein 2 (CAP2) leads to cardiomyopathy

“…Similarly, gene disruption of FKBP12.6, phospholamban, and ERa revealed a cardiac phenotype with male preponderance [42][43][44]. Studies with patients hospitalized for acute heart failure in the EuroHeart Failure Survey II revealed that men had DCM more frequently than women [45]. The exact molecular mechanism is still unknown, but the hypothesis is that estrogen prevents the development of cardiovascular diseases that could culminate into CHF [37].…”

Prognostic factors for progression of early- and late-stage calcific aortic valve disease in Japanese: The Japanese Aortic Stenosis Study (JASS) Retrospective Analysis

“…A valvular origin of heart failure, such as aortic stenosis, was more common in women than in men. 28,29 However, some studies of Caucasian patients found that male gender was a prognostic factor for the development of aortic stenosis, 6,7 whereas others found no influence of gender. 11,20 The effects of gender on coronary artery calcification differed even between patient cohorts from the Western countries.…”