Gender-related differences in susceptibility to oxidative stress in healthy middle-aged Serbian adults

Topić, Aleksandra; Malic, Zivka; Francuski, Djordje; Stanković, Marija; Marković, Bojan; Soskic, Blagoje; Tomic, Branko; Ilić, Stefan D.; Dobrivojevic, Snezana; Drca, Sanja; Radojković, Dragica

doi:10.3109/1354750x.2015.1126647

Cited by 8 publications

(6 citation statements)

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“…Besides, only few investigations studied the effect of sex and age on TB. To identifying the strongest predictors of TB levels, Topic et al [ 21 ] investigated 97 males and 68 females who were aged from 39 to 65 years. In males, fasting serum insulin levels and fatty acids consumption were the strongest.…”

Section: Discussionmentioning

confidence: 99%

“…There were no paper investigating TB and triglyceride (TG) directly, several papers mentioned that there were a negative relationship between them though. But these papers had limitations, for instance: the age distribution of the subjects was uneven [ 11 , 12 , 20 , 21 ], gender differences were not studied [ 11 , 13 ], small recruitment size [ 9 , 21 ], limited studies in Chinese people [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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The association between total bilirubin and serum triglyceride in both sexes in Chinese

Zhang¹,

Meng²,

Li³

et al. 2018

Lipids Health Dis

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ObjectiveDyslipidemia can cause some chronic diseases. Bilirubin is reported to have anti-inflammatory and anti-oxidant properties. We aimed to explore the relationship between triglyceride and total bilirubin (TB) in a large Chinese cohort.MethodsA total of 80,298 healthy Chinese (48,971 male, 31,327 female) enrolled in this cross-sectional study. Clinical data were collected from participants. Database was divided according to sex and age. The relationship between triglyceride and TB was analyzed by quartiles of TB. Levels of triglyceride were compared in different TB subgroups by one-way analysis of variance and independent sample’s t-test. Crude and adjusted odds ratios of triglyceride for TB with 95% confidence intervals were analyzed by binary logistic regression models.ResultsOverall, men showed higher levels of TB and triglyceride than women. In people older than 60 years, women had higher triglyceride levels than men. Linear logistic regression analyses showed a negative relationship between triglyceride and TB in both genders. Men showed significantly higher overall incidence of high triglyceride than women. Men less than 60 years old showed a higher incidence of high triglyceride. For women older than 60 years, the incidence of high triglyceride was higher. However, high TB showed no protective effects on both genders from high TG in the binary logistic regression models. TB showed a detrimental effect on high TG in model 2 which included TB as a covariate. But that effect disappeared after other confounding factors were included.ConclusionsOur findings showed no association between TB and triglyceride in Chinese.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The association between total bilirubin and serum triglyceride in both sexes in Chinese

Zhang¹,

Meng²,

Li³

et al. 2018

Lipids Health Dis

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“…Cellular homeostasis impairment related to excessive oxidative stress and ROS accumulation leads to alteration in memory impairment and neuronal degeneration (Beckhauser et al, 2016 ). Further, other factors such as aging increase vulnerability to accumulated oxidative stress and ROS (Topic et al, 2016 ). Here, we observed the aggravated ROS and MDA accumulation through ROS and LPO assays in the brain of mice compared to the control mice ( Figures 4A–D ).…”

Section: Resultsmentioning

confidence: 99%

Cadmium, an Environmental Contaminant, Exacerbates Alzheimer’s Pathology in the Aged Mice’s Brain

Ali

Khan

Alam

et al. 2021

Front. Aging Neurosci.

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Cadmium (Cd) is an environmental contaminant, which is a potential risk factor in the progression of aging-associated neurodegenerative diseases. Herein, we have assessed the effects of chronic administration of Cd on cellular oxidative stress and its associated Alzheimer’s disease (AD) pathologies in animal models. Two groups of mice were used, one group administered with saline and the other with Cd (1 mg/kg/day; intraperitoneally) for 3 months. After behavioral studies, molecular/biochemical (Immunoblotting, ELISAs, ROS, LPO, and GSH assays) and morphological analyses were performed. We observed an exacerbation of memory and synaptic deficits in chronic Cd-injected mice. Subacute and chronic Cd escalated reactive oxygen species (ROS), suppressed the master antioxidant enzymes, e.g., nuclear factor-erythroid 2-related factor 2 and heme oxygenase-1, and evoked the stress kinase phospho-c-Jun N-terminal kinase 1 signaling pathways, which may escalate AD pathologies possibly associated with amyloidogenic processes. These findings suggest the regulation of oxidative stress/ROS and its associated amyloid beta pathologies for targeting the Cd-exacerbated AD pathogenesis. In addition, these preclinical animal studies represent a paradigm for epidemiological studies of the human population exposed to chronic and subacute administration of Cd, suggesting avoiding environmental contaminants.

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“…On the other hand, with regard to oxygen free radical level according to sex, there are reports that oxygen free radical levels in females are significantly higher than those of males (Khadir et al, 2015), and that females are more vulnerable to oxidative stress (Topic et al, 2016). However, another report states that there are no differences between the sexes (Kirshbaum, 2002).…”

Section: Discussionmentioning

confidence: 99%

Factors Influencing the Level of Oxygen Free Radicals in Female Nursing Students

Kim¹,

Song²

2019

GJHS

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This study was conducted to investigate the levels of oxygen free radicals and related health factors in 201 female nursing students. The questionnaire was completed by the participants and their oxygen free radical levels were measured by urine test. In this study, an oxygen free radical analyzer was used to measure oxygen free radical levels. The oxygen free radical analyzer analyzes the amount of oxygen free radicals in the body by measuring urinary malondialdehyde (MDA). To determine factors associated with oxygen free radical levels, multiple regression tests were conducted. Of the participants, 89.6% exhibited normal levels of oxygen free radicals and 10.4% had elevated levels. In this study, the factors that affected oxygen free radical levels were eating habit (β = .20, p =. 003), fatigue (β = .20, p = .004), and detox necessity (β = .18, p = .006). In order to lower oxygen free radical levels of female nursing students, the areas of eating habit, fatigue, and detox must receive increased focus.

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Gender-related differences in susceptibility to oxidative stress in healthy middle-aged Serbian adults

Cited by 8 publications

References 50 publications

The association between total bilirubin and serum triglyceride in both sexes in Chinese

The association between total bilirubin and serum triglyceride in both sexes in Chinese

Cadmium, an Environmental Contaminant, Exacerbates Alzheimer’s Pathology in the Aged Mice’s Brain

Factors Influencing the Level of Oxygen Free Radicals in Female Nursing Students

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