Gender-specific association of coronary artery calcium and lipoprotein parameters: The Heinz Nixdorf Recall Study

Erbel, Raimund; Lehmann, Nils; Churzidse, Sofia; Möhlenkamp, Stefan; Moebus, Susanne; Mahabadi, Amir A.; Schmermund, Axel; Stang, Andreas; Dragano, Nico; Grönemeyer, Dietrich; Seibel, Rainer; Kälsch, Hagen; Bauer, Marcus; Bröcker-Preuß, Martina; Mann, Klaus; Jöckel, Karl‐Heinz

doi:10.1016/j.atherosclerosis.2013.04.015

Cited by 36 publications

(29 citation statements)

References 45 publications

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“…On the basis of our results, we propose a new anti-atherogenic role of HDL, but we do not neglect the other already described anti-atherogenic properties of HDL Interestingly, traditional risk factors for atherosclerosis, such as LDL-cholesterol, triglyceride concentrations, plasma glucose, smoking and blood pressure, did not make any contribution to the CAC score in the multivariate analysis (data not shown). This observation is consistent with the recent report of a poor correlation between plasma lipids and CAC scores [19]. Moreover, the logistic regression analysis failed to demonstrate a relationship between high CAC scores and HDL subclasses.…”

Section: Discussionsupporting

confidence: 93%

“…CAC scores may be useful in improving the algorithms used to evaluate the risk of CAD [15e17,19]. The significant influences of age and gender on CAC scores have been previously noted [17,19]. For this reason, we decided to integrate our study groups based on their CAC scores, standardized by age and gender.…”

Section: Discussionmentioning

confidence: 98%

“…Subclinical atherosclerosis may be detected by computed tomography (CT)-based imaging of coronary artery calcifications (CAC), which enhances the evaluation of CAD risk [15e17]. CACs are quantified using Agatston scores [18], which are strongly dependent on age and gender [18,19]. The relationship between CAC and lipoproteins, particularly HDL-cholesterol, was recently described [20e24].…”

Section: Introductionmentioning

confidence: 99%

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Low concentrations of phospholipids and plasma HDL cholesterol subclasses in asymptomatic subjects with high coronary calcium scores

et al. 2015

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Low concentrations of phospholipids and plasma HDL cholesterol subclasses in asymptomatic subjects with high coronary calcium scores

et al. 2015

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“…Further, ApoB were associated with increases in Coronary Artery Calcium (CAC) scores in women [18] and CAC scores in women have been associated with increases in cardiovascular events [19]. Our study was inconclusive in finding an enhanced role for ApoB in predicting future cardiovascular events in women.…”

Section: Discussioncontrasting

confidence: 49%

Can Apolipoproteins apoB and apoB/apoA1 Ratio Predict Future Cardiovascular Risk Post Acute Coronary Syndrome? A Retrospective Cohort Study

Desplantie¹,

Ramanathan²

2016

J Clin Exp Cardiolog

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“…Previously, in a large cohort, Apo B and non‐HDL cholesterol were strongly correlated with the presence of coronary calcium 34. However, the Apo B/Apo A1 ratio may predict the risk of atherosclerotic disease better than the LDL/HDL ratio,9 and a high Apo B/A1 ratio was strongly associated with MI in the INTERHEART case‐control study 35.…”

Section: Discussionmentioning

confidence: 92%

Lipoprotein(a) and the Apolipoprotein B/A1 Ratio Independently Associate With Surgery for Aortic Stenosis Only in Patients With Concomitant Coronary Artery Disease

Ljungberg

Holmgren

Bergdahl

et al. 2017

JAHA

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BackgroundAortic stenosis (AS) has different clinical phenotypes, including AS with or without concomitant coronary artery disease (CAD). It is unknown whether these phenotypes share the same risk factors. In particular, lipoprotein(a) [Lp(a)] and apolipoproteins (Apo) are associated with AS, but it is unknown whether these associations differ among phenotypes. In this prospective analysis we examined the impact of Lp(a) and Apo in subgroups of patients with AS.Methods and ResultsWe identified 336 patients (mean age at survey 56.7 years, 48% female) who underwent surgery for AS after a median 10.9 years (interquartile range 9.3 years), participants in 1 of 3 large population surveys. For each patient, 2 matched referents were allocated. Lp(a) and Apo were analyzed in the baseline samples. Uni‐ and multivariable logistic regression analyses were used to estimate risks related to a 1 (ln) standard deviation increase in Lp(a) and the ratio of Apo B to Apo A1 (Apo B/A1 ratio). High levels of Lp(a) predicted surgery for AS in 203 patients with concomitant CAD (odds ratio [95% confidence intervals]) (1.29 [1.07‐1.55]), but not in 132 patients without CAD (1.04 [0.83‐1.29]) in the fully adjusted model. Similarly, a high Apo B/A1 ratio predicted surgery in patients with concomitant CAD (1.43 [1.16‐1.76]) but not in those without CAD (0.87 [0.69‐1.10]).ConclusionsHigh levels of Lp(a) and a high Apo B/A1 ratio were associated with surgery for AS in patients with concomitant CAD but not in those with isolated AS. This finding may lead to a new avenue of research for targeted risk factor interventions in this population.

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Gender-specific association of coronary artery calcium and lipoprotein parameters: The Heinz Nixdorf Recall Study

Cited by 36 publications

References 45 publications

Low concentrations of phospholipids and plasma HDL cholesterol subclasses in asymptomatic subjects with high coronary calcium scores

Low concentrations of phospholipids and plasma HDL cholesterol subclasses in asymptomatic subjects with high coronary calcium scores

Can Apolipoproteins apoB and apoB/apoA1 Ratio Predict Future Cardiovascular Risk Post Acute Coronary Syndrome? A Retrospective Cohort Study

Lipoprotein(a) and the Apolipoprotein B/A1 Ratio Independently Associate With Surgery for Aortic Stenosis Only in Patients With Concomitant Coronary Artery Disease

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